The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Topic summary

Pre-registering a personal experiment, seriously

This is a generated summary. It shows the 9 most-liked posts from a topic of 120, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
PA
p.amankwahTL224 May 2025#1

Pre-registering a personal experiment, seriously — setting out what I have, and where I think it stops being reliable.

A narrow question about pre-registering a personal experiment, deliberately narrow, because the broad version has been asked here four times and produced four long threads and no answer.

One question, stated units, stated method, and what I have already ruled out.

46 likes 14mo
JL
j.lokkenTL225 May 2025#5
s.stavrianos, post #4: A single-person experiment can be genuinely informative if it has a pre-specified outcome, a defined period, and a plan written before the data arrives. Most accounts here have none of those. Not the whole picture, but the part of it I can speak to. Go to post

Agreed, and I will stop repeating the version of this I had been repeating.

33 likes in reply to #4 14mo
AK
a.kowalskiTL226 May 2025#16

Record everything that changed, not just the intervention. Personal experiments are confounded by life, and the confounders are only recoverable if they were written down.

I would be interested in a counterexample if anyone has one.

33 likes 14mo
SO
s.okaforTL228 May 2025#28
dr_bhattacharya, post #25: I read post #23 twice before replying, because I had assumed the opposite. The most useful thing anyone has posted about pre-registering a personal experiment in this category was a table of what had been measured and by whom. That is what I would want again. Go to post

A single-person experiment can be genuinely informative if it has a pre-specified outcome, a defined period, and a plan written before the data arrives. Most accounts here have none of those.

I have deliberately not rounded that, because the rounding is where the argument starts.

26 likes in reply to #25 14mo
SV
s.vanheckeTL228 May 2025#36

A methods point on pre-registering a personal experiment rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method.

28 likes 14mo
LV
l.vermeulenTL229 May 2025#48

I disagree with the framing of pre-registering a personal experiment above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be checked.

The reasoning depends on an assumption that is doing a lot of work and is never stated. If the assumption holds, the conclusion follows. I do not think it holds generally.

29 likes 14mo
RS
r.serranoTL230 May 2025#56

A single-person experiment can be genuinely informative if it has a pre-specified outcome, a defined period, and a plan written before the data arrives. Most accounts here have none of those.

Not a strong opinion, just a consistent one.

31 likes 14mo
IR
i.rasmussenTL231 May 2025#63

Write down what you would accept as evidence that it did not work, before starting. That one sentence turns an anecdote into an experiment.

Small point, but it is the one that usually catches people.

29 likes 14mo
KA
k.agyemanTL22 Jun 2025#95

Pre-registering a personal experiment: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly the information that would settle this.

32 likes 14mo

Read the full topic (120 posts)

Suggested topics

TopicParticipantsRepliesViewsActivity
Designing a personal experiment that could change your mind
Posting this under the heading it deserves: Designing a personal experiment that could change your mind Everything below is what sits behind that. I was wrong about designing a personal experiment in a thread…
MGECFACHG+2 6 695 6mo
Washout with a one-week half-life: the arithmetic — does this still hold?
Washout with a one-week half-life: the arithmetic — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Washout: setting out the arithmetic in full,…
AFANABANNN+41 45 12k 1d
Blinding yourself: practical methods and their limits — the long version
Blinding yourself: practical methods and their limits — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Blinding yourself,…
CTSDNGJEMD+7 11 1.8k 22h
An ABAB design with a data table and honest limitations
An ABAB design with a data table and honest limitations Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about ABAB design rather than a disguised…
SSDSEF 2 45k 5mo
An ABAB design with a data table and honest limitations — a second dataset
On the subject in the title: An ABAB design with a data table and honest limitations — a second dataset Working notes rather than a conclusion. Posting a small dataset on ABAB design. It is mine, it is…
VELIGRAC+106 118 25k 4mo

Related topics — sharing the tags worked example, data table, effect size

TopicParticipantsRepliesViewsActivity
Carryover and the ghost peak from last week's standard — what changed since
Carryover and the ghost peak from last week's standard — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Carryover…
FDLTZYFWAA+98 114 37k 22d
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset
Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Posting a small dataset on SURMOUNT-4 and…
VMLADNWMD+58 64 17k 13mo
List price versus negotiated price versus what you pay
On the subject in the title: List price versus negotiated price versus what you pay Working notes rather than a conclusion. List price versus negotiated price — I have the observation and I do not trust my…
JPJAVFVBCA+99 115 11k 3mo
Preprint servers and what screening they do — the long version
On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. A preprint question rather than a question about the finding in it. The…
APNEYASSRM+7 11 26k 4mo
Coming back to: Column chemistry choices for a 40-residue peptide
On the subject in the title: Column chemistry choices for a 40-residue peptide Working notes rather than a conclusion. Column chemistry choices — I have the observation and I do not trust my interpretation of…
MLFPHB 2 43k 16mo