"Should I double up?" — answered once, at length, calmly

"Should I double up?" — answered once, at length, calmly — setting out what I have, and where I think it stops being reliable.

A practical question that I suspect has a boring answer, which is why I could not find it discussed.

The maintained page covers the general case well. My case is one step off it, and the step looks small enough that it probably does not matter — which is exactly the reasoning that has caught me out before.

What I would like is somebody to tell me whether the step is genuinely small or whether it only looks that way.

Understood, and I withdraw the assumption I opened with.

Injection discomfort: comes from needle gauge (finer = less discomfort), volume (smaller = less discomfort), temperature (room temperature or warmed is less uncomfortable than cold), and technique (smooth, purposeful injection is less uncomfortable than hesitant). All four are under your control.

I would rather say I do not know than round it up to an answer.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

The conclusion is tentative; the arithmetic underneath it is not.

Drawing up with one needle and injecting with another: a reasonable practice if you have extra needles. Fresh needle for injection reduces tissue drag and can decrease discomfort. Not necessary, but not harmful either.

The step people skip is the one I have spelled out.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

That much is documented. The rest is how I have interpreted it.

Air bubbles in a subcutaneous injection: the honest risk assessment is low. Tiny air bubbles in subcutaneous tissue do not behave like an air embolism in a blood vessel. A few air bubbles are not a reason to restart the entire injection.

Where I would look next, rather than where I would stop.

Post #7 is the version of this I will quote in future. One addition.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

It is the kind of thing that is obvious once and never again.

I had read the opposite somewhere and cannot now find where, which tells me something.

This follows post #7 rather than contradicting it.

Nothing in this subcategory is medical advice and none of it is a substitute for a demonstration from somebody qualified to give one, which most prescribers will do without being asked twice.

The number is defensible. The precision I gave it is not.

Narrowing post #8, because the general version has more than one answer.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

None of the above is medical advice and I am not qualified to give any.

Air in the syringe is a much smaller problem subcutaneously than the anxiety about it suggests, and it is still worth expelling because the bubble occupies volume you meant to be liquid.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

That reframing is the whole thing. The facts I already had.