Useful. I had the fact and not the reason, which turns out to be the important half.
27 likes 9mo
Devices · Cold chain · continued
Temperature loggers worth the money — the long version posts 61–90
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
chromatogram, post #44: Assessing an excursion: if a package sat at room temperature for a time, visual inspection (cloudiness, discoloration, particles) can alert you to problems. Not visible does not mean not damaged, but visible problems are a reason to contact the supplier. The general case is well covered; this is the awkward specific one. Go to post
Answering the question post #58 raises rather than the one it answers.
A phase-change pack holds a defined temperature while it changes state and then behaves like anything else. A gel pack starts cold and warms continuously. They are different tools for different transit lengths.
Customs holds are the most common cause of an unexpectedly long transit, and they are also the segment nobody has visibility of. Tracking gaps are usually that rather than a lost parcel.
That holds under the stated conditions and I have stated them.
2 likes 9mo
Collapsed as off-topic by two members at trust level 3 or above
Worth separating Temperature loggers worth the money as a question about the compound from Temperature loggers worth the money as a question about the documentation. They get answered by different people and only one of them is answerable here.
Narrowing post #63, because the general version has more than one answer.
Adding the boring version of Temperature loggers worth the money, because the interesting version keeps getting posted and the boring one is usually right.
Check the ordinary explanations, in order, and stop when one of them accounts for what you are seeing. Most of the time the second one does.
19 likes 9mo
t.kulkarni, post #54: Reporting rather than recommending, on Temperature loggers worth the money. What happened is above. Whether it should have is a different question and not one I am qualified to answer. Go to post
Everything in post #62 holds. The case it does not cover is the one I have.
A parcel sitting in a vehicle or a depot in a hot month is the excursion that matters and the one nobody sees. Delivery timing is part of the cold chain.
That has held every time I have looked, which is not the same as always.
Temperature excursions: brief excursions above 8 °C are tolerable for most compounds. Hours to a day at room temperature is usually acceptable. Days to weeks at room temperature risks degradation.
If that reads as pedantic, it is, and it has saved me twice.
0 likes 9mo
Post #69 describes the usual case. This is about the unusual one.
Travel with medication: carrying a vial across borders requires planning if temperatures will exceed the range or if journey time is long. Insulated travel cases with ice packs are common solutions.
18 likes 9mo
m.steiner, post #10: On post #8 — agreed on the reasoning, with one qualification. Travel with medication: carrying a vial across borders requires planning if temperatures will exceed the range or if journey time is long. Insulated travel cases with ice packs are common solutions. On balance I think that is right, and I would not bet much on it. Go to post
An honest declaration on Temperature loggers worth the money: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.
Noted, and I have changed what I was going to do on the strength of it.
1 like 8mo
KAndersson, post #35: Everything in post #33 holds. The case it does not cover is the one I have. Lyophilised material is far more tolerant of a warm transit than a solution would be, which is why suppliers ship dry and why an excursion is not automatically a loss. It is the sort of thing that seems obvious in retrospect and was not at the time. Go to post
Shipment during summer or to hot climates: consider shipping to a cold-storage facility rather than to home if temperatures will be high. Alternatively, time shipment to arrive when you can refrigerate immediately.
Collapsed as off-topic by two members at trust level 3 or above
Do not judge cold-chain performance from a single delivery in either direction. It is a distribution and one sample from it is one sample.
I would not lead a decision with this, but I would not ignore it either.
Coming back to post #74, because the follow-up matters more than the original answer.
If you are not going to be there, arranging a secure delivery point is worth more than any packing decision the supplier can make.
Adding it in case it saves somebody the afternoon it cost me.
0 likes 8mo
Arrival condition tells you about the last few hours and very little about the middle of the journey. A pack that is soft on arrival may have been soft for four days or for four hours.
That is what I would do. It may not be what is correct.
0 likes 8mo
Narrowing post #77, because the general version has more than one answer.
Suppliers that reship after a documented excursion without argument are doing something commercially costly, and it is worth recording when they do.
I looked this up rather than remembered it, which is the right order.
17 likes 8mo
Temperature loggers worth the money would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
27 likes 8mo
baseline_table, post #73: Noted, and I have changed what I was going to do on the strength of it. Go to post
Adding a null result on Temperature loggers worth the money. I looked, carefully, and found nothing, and null results deserve posting precisely because they never are.
m.yilmaz, post #19: I read post #15 twice before replying, because I had assumed the opposite. Careful with the language on Temperature loggers worth the money. "Not detected" and "not present" are different findings and the first is a statement about the method. Go to post
A temperature indicator that has tripped tells you a threshold was crossed. It does not tell you for how long, and duration is most of what determines whether anything happened.
Worth separating two things that post #80 runs together.
Where the Temperature loggers worth the money reasoning breaks down for me is the step from the group result to the individual case. That step is almost never argued for.
13 likes 8mo
Confirming post #82 from a second method, which matters more than confirming it from a second person.
An update on my earlier Temperature loggers worth the money post: the pattern held for another six weeks and then stopped, which I did not predict and cannot explain.
0 likes 8mo
j.falk, post #68: Domestic refrigeration: most lyophilised peptides are stored at 2–8 °C (35–46 °F). That is standard refrigerator temperature. Check your refrigerator's actual temperature; some are warmer than the label. Go to post
Temperature logging: devices that record temperature over time let you confirm cold chain was maintained. Useful if a shipment was delayed or if you are concerned about excursion.
Everything in post #88 holds. The case it does not cover is the one I have.
Travel with medication: carrying a vial across borders requires planning if temperatures will exceed the range or if journey time is long. Insulated travel cases with ice packs are common solutions.
I have left out the parts I could not verify.
29 likes 8mo