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Clinical · Bloodwork · continued

Which panel is worth repeating and which is worth ignoring posts 121–134

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

LM
lyophil_marginTL3Regular26 Sep 2025 · edited#121

What I would tell a new member reading about panel for the first time: the confident posts are not the reliable ones, and the reliable ones are longer.

4 likes 10mo
MY
m.yildizTL227 Sep 2025#122
i.dumitru, post #83: Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is comparing things that are not the same. The evidence for this is thinner than the way I have phrased it suggests. Go to post

Post #118 describes the usual case. This is about the unusual one.

A trend needs at least three points to be a trend. Two points are a line and a line through noise is still a line.

The strength of my opinion here exceeds the strength of my evidence.

12 likes in reply to #83 10mo
KF
k.farrugiaTL3Regular28 Sep 2025#123

Post #120 is the version of this I will quote in future. One addition.

Adding a null result on panel. I looked, carefully, and found nothing, and null results deserve posting precisely because they never are.

26 likes 10mo
RO
r.oyelaranTL229 Sep 2025#124

Glycaemic markers integrate over different periods. A point glucose and a longer-term marker disagreeing is not a contradiction; it is two different questions.

0 likes 10mo
RT
r.torrenceTL2Member30 Sep 2025#125
a.kowalski, post #45: Post #41 describes the usual case. This is about the unusual one. Checked the panel claim against the primary source this morning. It survives, with a narrower scope than the version quoted here. Posting the narrower scope. Go to post

Where the panel reasoning breaks down for me is the step from the group result to the individual case. That step is almost never argued for.

7 likes in reply to #45 10mo
DN
d.nwosuTL21 Oct 2025#126
a.sorensen, post #73: Panel has been discussed here with more heat than it deserves, mostly because two definitions have been in play the whole time. Go to post

A note on scope: what I am saying about panel applies to the case in the first post and I would not extend it further without checking.

18 likes in reply to #73 10mo
EM
e.mikkelsenTL2Member3 Oct 2025#127

Confirming post #124 from a second method, which matters more than confirming it from a second person.

Where a panel includes a calculated value, that value inherits the imprecision of everything it was calculated from and is usually reported without an interval.

If that reads as pedantic, it is, and it has saved me twice.

0 likes 10mo
ET
e.tammTL24 Oct 2025#128
TN
t.nguyen_newTL1Member5 Oct 2025#129

Glycaemic markers integrate over different periods. A point glucose and a longer-term marker disagreeing is not a contradiction; it is two different questions.

0 likes 10mo
GB
g.bakkenTL26 Oct 2025#130

The version of panel that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.

4 likes 10mo
B
BGiordanoTL2Member7 Oct 2025#131
s.cardoso, post #44: Counterpoint on panel, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has ruled the dull one out. Go to post

Worth separating two things that post #129 runs together.

General information rather than advice about anyone's care. A single value outside a reference interval, on a single draw, in an otherwise unremarkable panel, is usually uninformative.

If anyone can point at the primary source I would be grateful.

1 like in reply to #44 10mo
AM
a.mwangiTL28 Oct 2025#132

Add biological variation and analytical imprecision to that base rate and the probability of a meaningless flag on a multi-analyte panel is substantial.

I would rather post the uncertainty than round it away.

0 likes 10mo
CD
cannula_driftTL3Regular9 Oct 2025#133

Reframing panel slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes. If it is "how often", nobody here knows.

24 likes 10mo
LD
l.dialloTL210 Oct 2025#134

Following this. I have the same question and no better information than the first post.

11 likes 10mo

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