Ranked by engagement

Top topics — this month page 11

Ranked by replies, likes and views over this month, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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374 topics · page 11 of 13

Topic	Participants	Replies	Views	Activity
Coming back to: Light exposure: how much protection is proportionate? Practice › Storage & stability temperature excursion cold chain freeze-thaw cloudy or discoloured solution Asking directly, because I could not find a straight answer: Light exposure: how much protection is proportionate? Reading back through what has been written here about Light exposure, three questions come up…	+5	10	13k	2d
[2026 update] Journal club: FLOW and the renal composite, component by component Evidence › Journal club journal club randomised trial estimand Journal club: FLOW and the renal composite, component by component Writing it up because I had to work it out twice and would rather nobody else did. A question about what the numbers mean rather than what…		2	21k	9d
A structured critique template this community uses Evidence › Study critique observational data effect size risk of bias A structured critique template this community uses — setting out what I have, and where I think it stops being reliable. Structured critique template — I have the observation and I do not trust my…		2	18k	1d
Impurity thresholds: where the common numbers come from Analytics › Impurities & related substances water content data table forced degradation counter-ion content Impurity thresholds: where the common numbers come from — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin impurity thresholds down and I want to set…	+11	15	825	2d
A 40-week log with the measurement method stated — what changed since Outcomes › Progress reports effect size data table DXA long read Solved A 40-week log with the measurement method stated — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on 40-week log. It is mine, it…	+9	13	2.1k	9h
About the Adverse events category Safety › Adverse events pancreatitis vomiting gallbladder Pinned Wiki Serious and unexpected events, how to document them, and where to report them officially. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+2	6	8.7k	2d
Second pass at: Orforglipron as a non-peptide: what changes when the molecule is small Compounds › Oral incretins PIONEER programme orforglipron randomised trial SOUL trial Second pass at: Orforglipron as a non-peptide: what changes when the molecule is small Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on…		2	17k	6h
Dizziness on standing: the ordinary explanation first — one year on Nutrition & Training › Hydration & electrolytes fatigue heart rate blood pressure Dizziness on standing: the ordinary explanation first — one year on — setting out what I have, and where I think it stops being reliable. A hydration and intake question, with the figures, since this one is…	+12	16	1.1k	2d
About the Welcome category Start Here › Welcome onboarding guidelines beginner friendly Pinned Wiki Introductions, orientation, and the pinned reading list for new members. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a note.…	+3	8	11k	27d
What consumer-accessible tests can and cannot determine Analytics › Home & field testing documentation quality ELISA third-party testing What consumer-accessible tests can and cannot determine — that is the question, and I have not found it answered plainly anywhere I have looked. Something about consumer-accessible tests does not reconcile…		2	17k	1h
About the Comorbidities category Clinical › Comorbidities type 2 diabetes chronic kidney disease MASH / hepatic steatosis Pinned Wiki Type 2 diabetes, hepatic steatosis, sleep apnoea, cardiovascular and renal disease. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	16k	12h
BPC-157: what the rodent literature actually shows, and what it does not — does this still hold? Compounds › Repair & healing peptides observational data needs a source BPC-157 TB-500 Solved The question in the title: BPC-157: what the rodent literature actually shows, and what it does not — does this still hold? I will give what I have already checked below so nobody repeats it. I would like to…	+6	10	3.1k	1d
Why pulsatile secretion matters for interpreting secretagogue claims Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin Why pulsatile secretion matters for interpreting secretagogue claims — that is the question, and I have not found it answered plainly anywhere I have looked. A follow-up question about pulsatile secretion…	+5	9	1.6k	15h
Cost versus information: making the trade-off explicitly Analytics › Home & field testing LOD & LOQ third-party testing ELISA documentation quality Cost versus information: making the trade-off explicitly Writing it up because I had to work it out twice and would rather nobody else did. Asking about cost versus information directly, because I have read…	+2	6	12k	11h
[2026 update] Journal club: what we got wrong in an earlier session Evidence › Journal club journal club effect size estimand number needed to treat Solved Journal club: what we got wrong in an earlier session — setting out what I have, and where I think it stops being reliable. Bringing a claim rather than a paper, because the claim is the thing circulating.…	+5	9	4.2k	1d
About the Shortages category Access › Shortages shortage compounding FDA Pinned Wiki Supply interruptions, official shortage notices, and managing an unplanned gap. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…	+3	7	9.9k	1d
A site rotation scheme that is easy enough to actually follow — a second dataset Practice › Administration subcutaneous injection needle gauge & length injection site rotation missed dose A site rotation scheme that is easy enough to actually follow — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before…	+6	10	1.2k	7h
What published stability data actually covers, and what it does not Practice › Storage & stability cloudy or discoloured solution freeze-thaw beyond-use date Solved Asking directly, because I could not find a straight answer: What published stability data actually covers, and what it does not A question about published stability data actually covers that I think has a…	+8	12	435	1d
Coming back to: Why I now write the concentration on the vial in marker Practice › Reconstitution reconstitution syringe units bacteriostatic water worked example The question in the title: Why I now write the concentration on the vial in marker I will give what I have already checked below so nobody repeats it. Writing this out with the numbers in it, because…	+8	12	4.3k	1d
Follow-up: How to disagree with an answer you were given, well Start Here › How to Ask onboarding worked example guidelines site feedback How to disagree with an answer you were given, well I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title and the context underneath, in the order the…		2	16k	30d
Adolescents: a distinct evidence base Clinical › Special populations older adults pregnancy & planning adolescents chronic kidney disease Adolescents: a distinct evidence base Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of adolescents is wrong? I ask because I have been…		3	11k	9h
Mobile reading experience on long topics Meta › Site feedback site feedback moderation guidelines Mobile reading experience on long topics Writing it up because I had to work it out twice and would rather nobody else did. Process question, and I have read the guidelines before asking. I understand the…		2	14k	4h
Coming back to: How much context is too much context in a first post? Start Here › How to Ask beginner friendly site feedback worked example onboarding Asking directly, because I could not find a straight answer: How much context is too much context in a first post? Counting it rather than describing it, because the count is the part that can be argued with.…	+2	6	7.5k	1d
The report format the maintainers ask for, and why each field is there Sourcing › Vendor reports disputed documentation quality batch & lot numbers certificate of analysis Solved On the subject in the title: The report format the maintainers ask for, and why each field is there Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…		4	6.3k	1d
Second pass at: Reading a trial's population section before its results Evidence › Trials open label intention to treat estimand surrogate endpoints Solved Second pass at: Reading a trial's population section before its results Writing it up because I had to work it out twice and would rather nobody else did. Reading STEP 1 ( N Engl J Med , 2021) for the…		4	9.5k	10h
Irish differences from the UK position — what changed since Regional › UK & Ireland personal import cost per milligram NHS Irish differences from the UK position — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Irish differences is wrong? I ask…	+8	12	782	1d
About the Announcements category Meta › Announcements guidelines trust levels moderation Pinned Wiki Staff announcements, policy changes, and scheduled maintenance. Read-only except for questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…	+3	7	8.7k	4h
German, French and Dutch differences, compared Regional › European Union cost per milligram formulary EMA German, French and Dutch differences, compared — setting out what I have, and where I think it stops being reliable. Asking about german directly, because I have read four threads on it and each answered a…		2	12k	10h
What to include when your question involves a laboratory result — a second dataset Start Here › How to Ask onboarding guidelines worked example site feedback Solved What to include when your question involves a laboratory result — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context…		2	7k	23d
What a statistical analysis plan adds that the paper does not Evidence › Trials open label discontinuation & dropout randomised trial surrogate endpoints Solved What a statistical analysis plan adds that the paper does not — that is the question, and I have not found it answered plainly anywhere I have looked. Statistical analysis plan, and specifically the version…		2	6.6k	10h