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414 topics · page 4 of 14

Topic	Participants	Replies	Views	Activity
A promotion I argued against, and why I lost — a second dataset Documentation › Doc review citation check promoted to docs wiki post A promotion I argued against, and why I lost — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on promotion. It is mine, it is…	+3	7	32k	12h
The anatomy of a question that gets answered within an hour Start Here › How to Ask worked example site feedback onboarding beginner friendly Wiki The anatomy of a question that gets answered within an hour — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the things…	+114	127	2.7k	13h
Rewriting my first post: a before-and-after, with commentary — what changed since Start Here › How to Ask site feedback onboarding beginner friendly worked example Posting this under the heading it deserves: Rewriting my first post: a before-and-after, with commentary — what changed since Everything below is what sits behind that. I want to check my reasoning rather…	+15	19	12k	13h
[2026 update] Antibiotics and a course of something with delayed emptying Practice › Interactions metformin needs a source delayed gastric emptying insulin On the subject in the title: Antibiotics and a course of something with delayed emptying Working notes rather than a conclusion. Something changed and I would like to know whether it should have. Same…	+88	97	19k	13h
Shoulders, tangent skims, and defensible integration Analytics › HPLC & UHPLC peak integration UV & DAD detection HPLC gradient method Posting this under the heading it deserves: Shoulders, tangent skims, and defensible integration Everything below is what sits behind that. Setting out an integration problem with the actual figures, because…	+16	20	11k	13h
Composite endpoints and the component doing the work Evidence › Trials randomised trial surrogate endpoints open label discontinuation & dropout Solved Under review Composite endpoints and the component doing the work Writing it up because I had to work it out twice and would rather nobody else did. Collecting what is known about composite endpoints in one place, because…	+3	7	33k	13h
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Evidence › Journal club risk of bias journal club effect size estimand Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Posting a small dataset on STEP 8. It is…	+18	22	656	13h
HbA1c lag and what it can and cannot tell you at eight weeks — one year on Clinical › Bloodwork liver enzymes lipase & amylase lipid panel thyroid function Posting this under the heading it deserves: HbA1c lag and what it can and cannot tell you at eight weeks — one year on Everything below is what sits behind that. A methods question rather than a substantive…	+18	22	655	13h
Tracking a shortage from primary sources rather than rumour Access › Shortages shortage FDA formulary Tracking a shortage from primary sources rather than rumour — setting out what I have, and where I think it stops being reliable. An honest uncertainty about tracking a shortage rather than a disguised…	+121	126	35k	13h
Coming back to: Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. Reading back through what has been written here about Solubility limits, three…	+38	43	29k	13h
About the N-of-1 designs category Research Methods › N-of-1 designs worked example confounding effect size Pinned Wiki Designing a personal experiment that could actually change your mind, including washouts and blinding. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	22k	14h
Why side effects reset at each escalation and that is not a failure Practice › Side effects constipation nausea fatigue delayed gastric emptying Solved Why side effects reset at each escalation and that is not a failure — that is the question, and I have not found it answered plainly anywhere I have looked. The question about side effects that I actually…	+3	7	11k	14h
Aggregate verification data across the directory, with caveats Sourcing › Independent verification Medutest blind sampling PeptideMeter Under review On the subject in the title: Aggregate verification data across the directory, with caveats Working notes rather than a conclusion. I have spent a fortnight trying to pin aggregate verification data down and…	+64	74	4.6k	14h
Talking to a therapist about this specifically Wellbeing › Mental health disordered eating beginner friendly mood Solved Posting this under the heading it deserves: Talking to a therapist about this specifically Everything below is what sits behind that. Something that has come up for me and that I suspect is more common than…	+20	24	855	14h
Follow-up: Sleep quality changes during weight loss Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. A follow-up question about Sleep quality changes during weight that I did not know to ask the…	+74	80	4.4k	14h
Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import cost per milligram MHRA Pinned On the subject in the title: Private prescribing in the UK: what is actually involved Working notes rather than a conclusion. The question about private prescribing that I actually want answered is the second…	+66	76	46k	14h
About the Impurities & related substances category Analytics › Impurities & related substances forced degradation counter-ion content water content Pinned Wiki Deletion sequences, oxidation, deamidation, aggregates, residual solvents, and counter-ion content. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+6	10	50k	15h
Why pulsatile secretion matters for interpreting secretagogue claims Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin Why pulsatile secretion matters for interpreting secretagogue claims — that is the question, and I have not found it answered plainly anywhere I have looked. A follow-up question about pulsatile secretion…	+5	9	1.6k	15h
Restarting after a long gap: what the labelling implies Practice › Dosing & titration dose reduction semaglutide titration missed dose Posting this under the heading it deserves: Restarting after a long gap: what the labelling implies Everything below is what sits behind that. I have read the maintained page on this and I still have a gap,…	+41	46	11k	15h
Journal club: semaglutide in MASH, and surrogate endpoints Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: semaglutide in MASH, and surrogate endpoints Everything below is what sits behind that. Working notes on semaglutide in MASH rather than a conclusion.…	+24	28	17k	15h
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…	+70	76	4.8k	15h
A structured critique template this community uses — a second dataset Evidence › Study critique observational data effect size confounding Solved On the subject in the title: A structured critique template this community uses — a second dataset Working notes rather than a conclusion. Posting a small dataset on structured critique template. It is mine,…	+47	51	16k	15h
Chain of custody for a sample you posted yourself — one year on Sourcing › Independent verification VendorInvestigate Janoshik Analytical blind sampling third-party testing Posting this under the heading it deserves: Chain of custody for a sample you posted yourself — one year on Everything below is what sits behind that. Posting a small dataset on Chain of custody. It is mine,…	+28	32	50k	15h
Follow-up: External review after an internal denial Access › Insurance & coverage prior authorisation formulary insurance Solved Posting this under the heading it deserves: External review after an internal denial Everything below is what sits behind that. Proposing that External review deserves a maintained page rather than a…	+6	10	12k	15h
Fixed versus detachable needles: the trade-offs — does this still hold? Devices › Syringes & needles syringe units needle gauge & length dead volume subcutaneous injection Solved Fixed versus detachable needles: the trade-offs — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Working notes on Fixed versus detachable…	+8	12	39k	15h
About the Reconstitution category Practice › Reconstitution reconstitution concentration maths syringe units Pinned Wiki Diluent choice, volumes, resulting concentrations, worked examples, and the errors we see most often. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	15k	16h
Molecular mass of semaglutide and why the figure differs between sources Compounds › Semaglutide SELECT trial effect size semaglutide STEP programme Molecular mass of semaglutide and why the figure differs between sources — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a question about a…	+101	110	12k	16h
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide retatrutide randomised trial effect size preprint Solved Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Writing it up because I had to work it out twice and would rather nobody else did. A methods question rather than a substantive…	+10	14	8.4k	16h
Coming back to: Reconciling a supplier certificate with an independent result Sourcing › Vendor reports documentation quality certificate of analysis batch & lot numbers Posting this under the heading it deserves: Reconciling a supplier certificate with an independent result Everything below is what sits behind that. Reconciling a supplier certificate — I have the observation…	+26	30	45k	16h
Fibre intake when total intake falls, and the constipation link — one year on Nutrition & Training › Protein & intake micronutrients lean mass loss fatigue Posting this under the heading it deserves: Fibre intake when total intake falls, and the constipation link — one year on Everything below is what sits behind that. An honest uncertainty about Fibre intake…	+9	13	16k	16h