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414 topics · page 6 of 14

Topic	Participants	Replies	Views	Activity
A community side-effect dataset, with its response rate and biases Data & Tools › Datasets confounding site feedback data table observational data Solved A community side-effect dataset, with its response rate and biases — setting out what I have, and where I think it stops being reliable. Community side-effect dataset: setting out the arithmetic in full,…		2	5.1k	19h
Why retatrutide discussion here is more cautious than elsewhere — one year on Compounds › Retatrutide TRIUMPH programme effect size preprint retatrutide Asking directly, because I could not find a straight answer: Why retatrutide discussion here is more cautious than elsewhere — one year on Two things I would like separated before anyone answers on…	+92	97	3.6k	20h
Lean mass preservation: what the evidence supports — does this still hold? Outcomes › Body composition bioimpedance lean mass loss data table DXA Asking directly, because I could not find a straight answer: Lean mass preservation: what the evidence supports — does this still hold? What changes if the standard account of Lean mass preservation is wrong?…	+112	122	5.2k	20h
Shakes versus food: a pragmatic assessment Nutrition & Training › Protein & intake lean mass loss micronutrients constipation Shakes versus food: a pragmatic assessment Writing it up because I had to work it out twice and would rather nobody else did. I would like to know what people here actually do about shakes versus food, as…	+22	26	53k	20h
Tracking intake honestly when appetite is absent Nutrition & Training › Protein & intake constipation fatigue micronutrients lean mass loss Solved On the subject in the title: Tracking intake honestly when appetite is absent Working notes rather than a conclusion. I have spent a fortnight trying to pin tracking intake down and I want to set out where I…	+109	115	4.8k	20h
Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry cloudy or discoloured solution storage counter-ion content Solubility limits and what a cloudy solution is telling you — setting out what I have, and where I think it stops being reliable. The question about solubility limits that I actually want answered is the…	+11	15	34k	20h
Review: a draft on reconstitution arithmetic, with objections — one year on Documentation › Doc review maintainership citation check promoted to docs review date Review: a draft on reconstitution arithmetic, with objections — one year on Writing it up because I had to work it out twice and would rather nobody else did. The question about draft on reconstitution…	+46	51	11k	20h
Publication patterns in the BPC-157 literature, examined Compounds › Repair & healing peptides preprint BPC-157 TB-500 needs a source Solved Posting this under the heading it deserves: Publication patterns in the BPC-157 literature, examined Everything below is what sits behind that. Putting the numbers in the first post, because a question about…	+40	45	3.4k	21h
A site rotation scheme that is easy enough to actually follow Practice › Administration needle gauge & length missed dose injection site rotation aseptic technique On the subject in the title: A site rotation scheme that is easy enough to actually follow Working notes rather than a conclusion. Two things I would like separated before anyone answers on site rotation…	+112	125	5.8k	21h
Revisiting: Spike-and-recover accuracy for a peptide assay Analytics › Method validation LOD & LOQ system suitability stability-indicating method linearity Revisiting: Spike-and-recover accuracy for a peptide assay — setting out what I have, and where I think it stops being reliable. I was wrong about Spike-and-recover accuracy in a thread last spring and I…		2	6.8k	21h
What I would want from a home test that does not exist yet — what changed since Analytics › Home & field testing third-party testing LOD & LOQ documentation quality ELISA Solved Asking directly, because I could not find a straight answer: What I would want from a home test that does not exist yet — what changed since Two reports on the same lot, and I would like help deciding whether…	+101	111	1.9k	21h
Journal club: the CagriSema phase 2 combination paper Evidence › Journal club randomised trial estimand effect size On the subject in the title: Journal club: the CagriSema phase 2 combination paper Working notes rather than a conclusion. CagriSema phase 2 combination paper — I have the observation and I do not trust my…		2	329	21h
Submitting a sample: the process end to end Sourcing › Independent verification blind sampling PeptideMeter VendorInvestigate third-party testing On the subject in the title: Submitting a sample: the process end to end Working notes rather than a conclusion. Submitting a sample keeps being re-asked here and I think that is because the answer is…	+99	114	29k	21h
Coming back to: When a red flag was a misunderstanding, and the retraction Sourcing › Red flags mislabelling moderation documentation quality When a red flag was a misunderstanding, and the retraction I have a specific reason for asking rather than idle curiosity, and the context is below. Red flag — I have the observation and I do not trust my…	+6	10	257	21h
Prior authorisation: what the criteria usually require — a second dataset Access › Insurance & coverage prior authorisation insurance formulary appeals Posting this under the heading it deserves: Prior authorisation: what the criteria usually require — a second dataset Everything below is what sits behind that. Posting a small dataset on Prior authorisation.…	+67	74	19k	21h
Prescription portability between countries — the long version Access › International EMA NHS telehealth On the subject in the title: Prescription portability between countries — the long version Working notes rather than a conclusion. A narrow question about Prescription portability between countries,…		2	182	21h
[2026 update] Waist circumference technique and its repeatability Outcomes › Progress reports DXA long read effect size data table Posting this under the heading it deserves: Waist circumference technique and its repeatability Everything below is what sits behind that. An honest uncertainty about Waist circumference technique rather than…	+23	27	5.9k	21h
Retatrutide mass and identity: what a report should show Compounds › Retatrutide TRIUMPH programme preprint retatrutide effect size Solved Posting this under the heading it deserves: Retatrutide mass and identity: what a report should show Everything below is what sits behind that. The question about retatrutide mass and identity that I actually…	+22	27	872	22h
Why cagrilintide alone is discussed so much less than in combination — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide effect size Solved Under review Why cagrilintide alone is discussed so much less than in combination — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Cagrilintide alone:…	+27	31	1.2k	22h
CJC-1295 with and without DAC: what the modification does Compounds › Secretagogues & GH axis needs a source tesamorelin CJC-1295 GHRP class On the subject in the title: CJC-1295 with and without DAC: what the modification does Working notes rather than a conclusion. Putting the numbers in the first post, because a question about a compound…	+117	123	5.6k	22h
Second pass at: Cost versus information: making the trade-off explicitly Analytics › Home & field testing third-party testing documentation quality ELISA Posting this under the heading it deserves: Second pass at: Cost versus information: making the trade-off explicitly Everything below is what sits behind that. Posting a small dataset on Cost versus…	+23	27	6.1k	22h
Immortal time bias in a claims-database study — one year on Evidence › Study critique effect size risk of bias confounding Solved Posting this under the heading it deserves: Immortal time bias in a claims-database study — one year on Everything below is what sits behind that. I would like to disagree carefully with the settled view on…	+41	46	3.7k	22h
What a good consultation looks like from the other side Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes beginner friendly What a good consultation looks like from the other side — that is the question, and I have not found it answered plainly anywhere I have looked. Something about good consultation does not reconcile and I…	+57	62	4.9k	22h
GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. I have spent a fortnight trying to pin GLP-1 receptor distribution…	+90	98	30k	22h
Review: a draft on reconstitution arithmetic, with objections — what changed since Documentation › Doc review promoted to docs wiki post review date citation check Posting this under the heading it deserves: Review: a draft on reconstitution arithmetic, with objections — what changed since Everything below is what sits behind that. What changes if the standard account…	+39	50	26k	22h
Blinding yourself: practical methods and their limits — the long version Research Methods › N-of-1 designs worked example effect size confounding data table Blinding yourself: practical methods and their limits — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Blinding yourself,…	+7	11	1.8k	22h
About the Independent verification category Sourcing › Independent verification Janoshik Analytical Medutest PeptideMeter Pinned Wiki Janoshik, Medutest, PeptideMeter and VendorInvestigate results, how to submit a sample, and how to read what comes back. This post is a community wiki: any member at trust level 3 or above can edit it, and…	+1	5	5.8k	23h
What would change my mind about repair peptides: a specific answer Compounds › Repair & healing peptides TB-500 needs a source preprint Under review What would change my mind about repair peptides: a specific answer — that is the question, and I have not found it answered plainly anywhere I have looked. Documentation question rather than a pharmacological…	+26	30	1.1k	23h
Journal club: what we got wrong in an earlier session Evidence › Journal club number needed to treat effect size randomised trial journal club On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Bringing a claim rather than a paper, because the claim is the thing circulating. The…	+114	125	2.5k	23h
Risk-of-bias tools and the judgement they conceal — does this still hold? Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about Risk-of-bias tools on behalf of…	+26	30	5.8k	23h