20 categories

Clinical

Laboratory interpretation, comorbidities, special populations, and preparing for a conversation with your own prescriber. General information only.

96 topics4,480 posts30 solved Moderators: bench_notes, hana.sato About this category

Bloodwork 30 Comorbidities 24 Special populations 22 Prescriber conversations 20

96 topics · page 2 of 4

Topic	Participants	Replies	Views	Activity
eGFR fluctuation and the creatinine denominator problem Clinical › Bloodwork eGFR & renal function liver enzymes lipid panel On the subject in the title: eGFR fluctuation and the creatinine denominator problem Working notes rather than a conclusion. Proposing that egfr fluctuation deserves a maintained page rather than a recurring…		2	10k	6d
Heart failure with preserved ejection fraction: symptom endpoints Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis blood pressure Heart failure with preserved ejection fraction: symptom endpoints — setting out what I have, and where I think it stops being reliable. Heart failure with preserved ejection keeps being re-asked here and I…	+19	23	311	12d
Osteoarthritis and mechanical versus metabolic improvement — one year on Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis obstructive sleep apnoea blood pressure Under review On the subject in the title: Osteoarthritis and mechanical versus metabolic improvement — one year on Working notes rather than a conclusion. Collecting what is known about Osteoarthritis and mechanical…	+52	56	8.1k	15d
Gastro-oesophageal reflux: improving or worsening? Clinical › Comorbidities PCOS obstructive sleep apnoea MASH / hepatic steatosis chronic kidney disease Solved The question in the title: Gastro-oesophageal reflux: improving or worsening? I will give what I have already checked below so nobody repeats it. Collecting what is known about gastro-oesophageal reflux in…	+54	58	8.2k	1mo
Reference intervals: how they are constructed and why one in twenty flags Clinical › Bloodwork HbA1c thyroid function eGFR & renal function lipase & amylase Under review Reference intervals: how they are constructed and why one in twenty flags — setting out what I have, and where I think it stops being reliable. Reference intervals: what I expected, what I found, and the gap…	+104	119	30k	1mo
[2026 update] What a good consultation looks like from the other side Clinical › Prescriber conversations beginner friendly type 2 diabetes telehealth The question in the title: What a good consultation looks like from the other side I will give what I have already checked below so nobody repeats it. Good consultation: what I expected, what I found, and the…	+32	36	13k	1mo
Getting a referral rather than a refusal Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes Getting a referral rather than a refusal — setting out what I have, and where I think it stops being reliable. What changes if the standard account of getting a referral is wrong? I ask because I have been…	+8	12	32k	2mo
Bariatric surgery history: altered anatomy, altered expectations Clinical › Special populations pregnancy & planning disordered eating older adults adolescents Solved Posting this under the heading it deserves: Bariatric surgery history: altered anatomy, altered expectations Everything below is what sits behind that. Asking about bariatric surgery history directly, because…	+35	39	486	2mo
[2026 update] Thyroid function tests during substantial weight change Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c thyroid function Thyroid function tests during substantial weight change Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Thyroid function tests during…	+69	74	4.5k	2mo
Type 2 diabetes and the largest part of the evidence base Clinical › Comorbidities chronic kidney disease obstructive sleep apnoea type 2 diabetes MASH / hepatic steatosis Posting this under the heading it deserves: Type 2 diabetes and the largest part of the evidence base Everything below is what sits behind that. Trying to work out what would count as evidence on type 2…	+81	89	2.9k	3mo
Pregnancy and pregnancy planning: contraindication and washout Clinical › Special populations pregnancy & planning bariatric surgery history chronic kidney disease disordered eating Closed Posting this under the heading it deserves: Pregnancy and pregnancy planning: contraindication and washout Everything below is what sits behind that. Pregnancy and pregnancy planning: setting out the…	+111	122	2.4k	3mo
Second pass at: Fasting versus non-fasting and which tests care Clinical › Bloodwork lipase & amylase liver enzymes lipid panel HbA1c On the subject in the title: Second pass at: Fasting versus non-fasting and which tests care Working notes rather than a conclusion. Posting a small dataset on Fasting versus non-fasting. It is mine, it is…	+20	25	21k	3mo
Which panel is worth repeating and which is worth ignoring — a second dataset Clinical › Bloodwork lipid panel liver enzymes eGFR & renal function lipase & amylase Asking directly, because I could not find a straight answer: Which panel is worth repeating and which is worth ignoring — a second dataset Posting a small dataset on panel. It is mine, it is uncontrolled, and…	+108	117	46k	4mo
Liver enzymes drifting down and what that usually means Clinical › Bloodwork HbA1c liver enzymes eGFR & renal function Solved Closed Liver enzymes drifting down and what that usually means — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about liver enzymes drifting.…	+66	72	12k	4mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies Clinical › Special populations chronic kidney disease bariatric surgery history older adults pregnancy & planning Older adults, sarcopenia risk, and the trade-off nobody quantifies — setting out what I have, and where I think it stops being reliable. Older adults: setting out the arithmetic in full, because I have had to…	+103	109	12k	5mo
Cardiovascular risk: reading the outcome trials as a set Clinical › Comorbidities MASH / hepatic steatosis chronic kidney disease type 2 diabetes obstructive sleep apnoea Cardiovascular risk: reading the outcome trials as a set Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here about cardiovascular…		4	12k	5mo
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Clinical › Special populations chronic kidney disease disordered eating older adults Solved Second pass at: Pregnancy and pregnancy planning: contraindication and washout Writing it up because I had to work it out twice and would rather nobody else did. Something about Pregnancy and pregnancy…	+111	127	1.6k	6mo
Hepatic steatosis: what the MASH trial evidence supports — one year on Clinical › Comorbidities MASH / hepatic steatosis obstructive sleep apnoea chronic kidney disease blood pressure Solved On the subject in the title: Hepatic steatosis: what the MASH trial evidence supports — one year on Working notes rather than a conclusion. Reading back through what has been written here about Hepatic…		2	4.1k	6mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Clinical › Special populations older adults chronic kidney disease adolescents disordered eating Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Older adults, deliberately…	+64	69	15k	7mo
History of disordered eating and why it changes the conversation Clinical › Special populations older adults chronic kidney disease adolescents bariatric surgery history Closed History of disordered eating and why it changes the conversation Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of history of…	+20	24	30k	8mo
Thyroid function tests during substantial weight change Clinical › Bloodwork lipase & amylase HbA1c liver enzymes eGFR & renal function Closed Posting this under the heading it deserves: Thyroid function tests during substantial weight change Everything below is what sits behind that. I was wrong about thyroid function tests during substantial in a…	+136	149	3.3k	8mo
Biological variation versus analytical imprecision — does this still hold? Clinical › Bloodwork HbA1c eGFR & renal function thyroid function lipid panel Solved Closed The question in the title: Biological variation versus analytical imprecision — does this still hold? I will give what I have already checked below so nobody repeats it. The question about Biological…		2	1.8k	8mo
[2026 update] A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipase & amylase liver enzymes lipid panel Solved Closed On the subject in the title: A single out-of-range value on an otherwise normal panel Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…	+15	19	53k	9mo
Revisiting: Gallbladder disease risk with rapid weight loss Clinical › Comorbidities MASH / hepatic steatosis chronic kidney disease PCOS obstructive sleep apnoea Revisiting: Gallbladder disease risk with rapid weight loss Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on…		2	2k	9mo
Which panel is worth repeating and which is worth ignoring Clinical › Bloodwork eGFR & renal function liver enzymes HbA1c Solved The question in the title: Which panel is worth repeating and which is worth ignoring I will give what I have already checked below so nobody repeats it. An honest uncertainty about panel rather than a…	+125	133	17k	10mo
Discussing something you have already been doing Clinical › Prescriber conversations prior authorisation type 2 diabetes beginner friendly telehealth Solved Under review On the subject in the title: Discussing something you have already been doing Working notes rather than a conclusion. A question about how to describe something to a clinician rather than about the thing…	+10	14	3.4k	10mo
Hypertension improvement and when medication needs revisiting Clinical › Comorbidities type 2 diabetes MASH / hepatic steatosis chronic kidney disease Closed Hypertension improvement and when medication needs revisiting Writing it up because I had to work it out twice and would rather nobody else did. Hypertension improvement: setting out the arithmetic in full,…	+74	79	1.1k	10mo
Hepatic impairment and the absence of data Clinical › Special populations older adults adolescents chronic kidney disease disordered eating Hepatic impairment and the absence of data — setting out what I have, and where I think it stops being reliable. I was wrong about hepatic impairment in a thread last spring and I would like to correct it…	+30	35	32k	10mo
Follow-up: History of disordered eating and why it changes the conversation Clinical › Special populations bariatric surgery history older adults pregnancy & planning chronic kidney disease Posting this under the heading it deserves: History of disordered eating and why it changes the conversation Everything below is what sits behind that. What changes if the standard account of History of…	+75	81	23k	10mo
Micronutrient status when intake falls substantially Clinical › Bloodwork lipase & amylase thyroid function lipid panel HbA1c Solved Wiki Closed On the subject in the title: Micronutrient status when intake falls substantially Working notes rather than a conclusion. Posting a small dataset on micronutrient status. It is mine, it is uncontrolled, and…	+26	30	367	11mo