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Topic summary

Dead volume across syringe and needle combinations

This is a generated summary. It shows the 9 most-liked posts from a topic of 81, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
EC
excursion_checkTL3Regular10 Sep 2025#1

On the subject in the title: Dead volume across syringe and needle combinations Working notes rather than a conclusion.

Something about dead volume across syringe does not reconcile and I would like a second pair of eyes before I decide which half is wrong.

Two sources, both reputable, giving figures that cannot both be right unless they are measuring different quantities. My suspicion is that they are, and I cannot see how.

42 likes 11mo
JF
j.falkTL227 Sep 2025#5
excursion_check, post #1: On the subject in the title: Dead volume across syringe and needle combinations Working notes rather than a conclusion. Something about dead volume across syringe does not reconcile and I would like a second pair of eyes before I decide which half is wrong. Two sources, both reputable, giving figures that cannot both be right unless… Go to post

That is the distinction I keep failing to hold on to. Written down now.

31 likes in reply to #1 10mo
YA
y.adebayoTL217 Oct 2025#12

I would put moderate confidence on the mainstream reading of dead volume across syringe and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.

26 likes 9mo
NM
n.moreauTL23 Nov 2025#19

Reusing a needle blunts it and there is no benefit to offset that. The second injection with the same needle is the one people describe as painful.

This is the version I would want a new member to read first.

27 likes 9mo
BS
buffer_sheetTL3Regular8 Dec 2025#35
ppm_error, post #25: Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters. Go to post

If your calculated volume is under two graduations, choose a lower concentration rather than trying to read between marks. Precision comes from the preparation, not the eye.

32 likes in reply to #25 8mo
RB
r.bruunTL220 Dec 2025#41
n.cardoso, post #28: A definition problem is doing most of the work in this dead volume across syringe discussion. Once the term is pinned down I suspect the disagreement mostly goes away and what is left is small. Go to post

Building on post #38 rather than restating it.

On dead volume across syringe, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the interesting bit.

If you can post the two or three numbers you are working from, several people here will check the arithmetic rather than argue about the conclusion.

31 likes in reply to #28 7mo
ST
sterile_tableTL3Regular6 Jan 2026#50
buffer_sheet, post #35: If your calculated volume is under two graduations, choose a lower concentration rather than trying to read between marks. Precision comes from the preparation, not the eye. Go to post

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

32 likes in reply to #35 7mo
BW
br.wikstromTL212 Jan 2026#53

That reframing is the whole thing. The facts I already had.

28 likes 6mo
RS
r.sobczakTL28 Feb 2026#68

Thank you — that answers what I came here to find out.

27 likes 6mo

Read the full topic (81 posts)

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