Ranked by engagement

Top topics — all time page 13

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 13 of 40

Topic	Participants	Replies	Views	Activity
Type 1 diabetes: off-label use and the evidence gap — what changed since Clinical › Special populations adolescents disordered eating older adults Solved Type 1 diabetes: off-label use and the evidence gap — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Type 1 diabetes is wrong?…	+68	77	31k	20mo
Choosing which test to pay for, given a fixed budget Sourcing › Independent verification third-party testing VendorInvestigate Medutest Janoshik Analytical On the subject in the title: Choosing which test to pay for, given a fixed budget Working notes rather than a conclusion. A question about how a record should be read rather than about a supplier. We have…	+60	70	49k	3mo
Asking a follow-up: new topic or new reply? Start Here › How to Ask worked example onboarding beginner friendly Solved Asking a follow-up: new topic or new reply? — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about asking a follow-up in one place, because it…	+68	73	40k	1d
UK access routes, dated and sourced — a second dataset Regional › UK & Ireland MHRA NHS cost per milligram personal import Posting this under the heading it deserves: UK access routes, dated and sourced — a second dataset Everything below is what sits behind that. Regional question, dated January 2026, because everything in this…	+76	82	25k	14mo
Request: show the solution author in the topic list — what changed since Meta › Feature requests site feedback wiki post translation Request: show the solution author in the topic list — what changed since — setting out what I have, and where I think it stops being reliable. Bringing the figures rather than the impression, since a process…	+79	91	20k	3mo
What to include when your question involves a chromatogram Start Here › How to Ask guidelines beginner friendly worked example Solved What to include when your question involves a chromatogram I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+49	54	58k	6mo
Gallbladder disease risk with rapid weight loss Clinical › Comorbidities obstructive sleep apnoea type 2 diabetes chronic kidney disease Solved Posting this under the heading it deserves: Gallbladder disease risk with rapid weight loss Everything below is what sits behind that. Gallbladder disease risk — I have the observation and I do not trust my…	+56	63	34k	18mo
Why the timeline is on the right and not the left Meta › Site feedback moderation site feedback guidelines Solved Why the timeline is on the right and not the left — that is the question, and I have not found it answered plainly anywhere I have looked. Something about timeline does not reconcile and I would like a second…	+67	73	19k	10mo
A widely repeated interaction claim that turns out to be unsupported — what changed since Practice › Interactions insulin hypoglycaemia metformin needs a source Solved A widely repeated interaction claim that turns out to be unsupported — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about widely repeated…	+89	94	5.9k	2h
Second pass at: Identical chromatograms across two different lots Sourcing › Red flags disputed mislabelling moderation Posting this under the heading it deserves: Second pass at: Identical chromatograms across two different lots Everything below is what sits behind that. Something about Identical chromatograms does not…	+81	93	13k	4mo
Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? Compounds › Semaglutide randomised trial type 2 diabetes STEP programme effect size Solved Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Practical question…	+58	62	49k	20mo
Micronutrient adequacy at low total intake Nutrition & Training › Protein & intake constipation fatigue lean mass loss Under review Micronutrient adequacy at low total intake — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on micronutrient adequacy, before collecting…	+93	99	5.8k	1mo
Dose numbers for oral formulations are not comparable to injectable ones — a second dataset Compounds › Oral incretins randomised trial orforglipron PIONEER programme Dose numbers for oral formulations are not comparable to injectable ones — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Dose…	+48	52	59k	18mo
Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation linearity recovery precision & repeatability system suitability On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Working notes rather than a conclusion. Trying to establish the boundary conditions on…	+93	99	1.4k	6d
Anxiety in the first weeks: drug, situation, or both — what changed since Wellbeing › Mental health mood disordered eating beginner friendly Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did. The question about Anxiety that I actually want…	+88	95	4.5k	5mo
Maintainer handover: how it works Meta › Wiki maintenance review date moderation citation check wiki post On the subject in the title: Maintainer handover: how it works Working notes rather than a conclusion. I would like to disagree carefully with the settled view on maintainer handover, and I would like to be…	+74	82	14k	16mo
Coming back to: Over-dilution: when your dose falls below one readable graduation Practice › Reconstitution worked example dead volume syringe units bacteriostatic water Over-dilution: when your dose falls below one readable graduation Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…	+90	97	1.1k	7mo
Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses heterogeneity risk of bias meta-analysis effect size Posting this under the heading it deserves: Heterogeneity as information rather than as a nuisance Everything below is what sits behind that. An honest uncertainty about heterogeneity rather than a disguised…	+88	95	1.2k	6mo
Hair shedding at month three: mechanism and time course — the long version Practice › Side effects nausea delayed gastric emptying vomiting Hair shedding at month three: mechanism and time course — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+50	54	50k	1d
Reading a supplementary appendix and finding the interesting part Evidence › Trials open label discontinuation & dropout intention to treat estimand Reading a supplementary appendix and finding the interesting part — setting out what I have, and where I think it stops being reliable. Collecting what is known about reading a supplementary appendix in one…	+87	92	1.1k	17mo
Coming back to: When "no data" is the complete and final answer Compounds › Other compounds research use only needs a source custom synthesis When "no data" is the complete and final answer I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about the compound itself rather than about a trial of it. I…	+77	82	12k	11mo
Type 2 diabetes and the largest part of the evidence base Clinical › Comorbidities chronic kidney disease obstructive sleep apnoea type 2 diabetes MASH / hepatic steatosis Posting this under the heading it deserves: Type 2 diabetes and the largest part of the evidence base Everything below is what sits behind that. Trying to work out what would count as evidence on type 2…	+81	89	2.9k	3mo
Transporting a vial for a weekend away — a second dataset Practice › Storage & stability storage cold chain beyond-use date Transporting a vial for a weekend away — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Transporting a vial. It is mine, it is…	+74	84	5.1k	1mo
Coming back to: Purity assay versus content assay: two different numbers Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers Under review Purity assay versus content assay: two different numbers — setting out what I have, and where I think it stops being reliable. Asking about Purity assay versus content assay directly, because I have read four…	+71	77	31k	23mo
Reading a preclinical wound-healing model and its relevance to a human tendon — a second dataset Compounds › Repair & healing peptides observational data preprint BPC-157 Reading a preclinical wound-healing model and its relevance to a human tendon — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Reading a…	+64	69	27k	4mo
Revisiting: What a well-designed human trial of a secretagogue would look like Compounds › Secretagogues & GH axis CJC-1295 observational data needs a source GHRP class On the subject in the title: Revisiting: What a well-designed human trial of a secretagogue would look like Working notes rather than a conclusion. Something about well-designed human trial does not reconcile…	+69	74	25k	18mo
Five questions in one post gets you one answer — how to split them Start Here › How to Ask guidelines site feedback worked example Closed On the subject in the title: Five questions in one post gets you one answer — how to split them Working notes rather than a conclusion. A narrow question about five questions, deliberately narrow, because the…	+85	90	1k	2mo
Travel coolers and how long they really hold Devices › Cold chain temperature excursion storage freeze-thaw On the subject in the title: Travel coolers and how long they really hold Working notes rather than a conclusion. A narrow question about travel coolers, deliberately narrow, because the broad version has…	+78	84	14k	12mo
Reporting a discrepancy without making an allegation Sourcing › Vendor reports batch & lot numbers disputed documentation quality certificate of analysis On the subject in the title: Reporting a discrepancy without making an allegation Working notes rather than a conclusion. Asking about reporting a discrepancy directly, because I have read four threads on it…	+79	89	1k	22mo
Follow-up: Requesting a page: what makes a good request Documentation › Wiki requests promoted to docs review date maintainership wiki post Solved On the subject in the title: Requesting a page: what makes a good request Working notes rather than a conclusion. Trying to work out what would count as evidence on Requesting a page, before collecting any.…	+44	50	64k	13mo