Ranked by engagement

Top topics — all time page 33

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 33 of 40

Topic	Participants	Replies	Views	Activity
Preservatives: function, testing, and limits — one year on Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage bacteriostatic water Wiki On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Asking about Preservatives directly, because I have read four threads on it and…	+28	32	437	8d
About the Mental health category Wellbeing › Mental health mood disordered eating beginner friendly Pinned Wiki Mood, anxiety, disordered eating history, and knowing when to involve a professional. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+4	8	34k	9mo
Meeting a protein target on a suppressed appetite — one year on Nutrition & Training › Protein & intake constipation fatigue lean mass loss micronutrients Solved Meeting a protein target on a suppressed appetite — one year on — setting out what I have, and where I think it stops being reliable. Asking about Meeting a protein target directly, because I have read four…	+15	19	19k	22mo
Biological variation versus analytical imprecision Clinical › Bloodwork lipase & amylase liver enzymes thyroid function HbA1c On the subject in the title: Biological variation versus analytical imprecision Working notes rather than a conclusion. A question about biological variation versus analytical imprecision that I think has a…		2	42k	12mo
About the Trials category Evidence › Trials randomised trial estimand intention to treat Pinned Wiki Individual randomised trials: design, population, endpoints, results, and limitations. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+6	10	27k	12mo
Second pass at: Two scans six weeks apart on different machines: a cautionary tale Outcomes › Body composition DXA bioimpedance lean mass loss data table Second pass at: Two scans six weeks apart on different machines: a cautionary tale Writing it up because I had to work it out twice and would rather nobody else did. A question about measurement precision…	+1	5	34k	8mo
Journal club: STEP 8 and the fairness of the comparator dose Evidence › Journal club estimand number needed to treat journal club Journal club: STEP 8 and the fairness of the comparator dose — setting out what I have, and where I think it stops being reliable. Session topic: STEP 8 ( JAMA , 2022). Please read it before posting; the…	+2	6	39k	12mo
About the Wiki maintenance category Meta › Wiki maintenance wiki post review date maintainership Pinned Wiki Review dates, orphaned pages, maintainer handovers, and revision disputes. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…		4	42k	15mo
LOD and LOQ: definitions people get wrong Analytics › Method validation precision & repeatability recovery stability-indicating method linearity Closed LOD and LOQ: definitions people get wrong — setting out what I have, and where I think it stops being reliable. What changes if the standard account of LOD and LOQ is wrong? I ask because I have been treating…		2	43k	8mo
A promotion I argued against, and why I lost — a second dataset Documentation › Doc review citation check promoted to docs wiki post A promotion I argued against, and why I lost — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on promotion. It is mine, it is…	+3	7	32k	12h
Anaesthesia and elective surgery: the aspiration question — does this still hold? Practice › Interactions needs a source hypoglycaemia metformin Solved Anaesthesia and elective surgery: the aspiration question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about Anaesthesia and…	+23	27	5.6k	17mo
Metformin co-administration and additive GI effects Practice › Interactions insulin hypoglycaemia metformin delayed gastric emptying Metformin co-administration and additive GI effects Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on metformin…	+28	32	2.1k	15mo
[2026 update] Waist circumference technique and its repeatability Outcomes › Progress reports DXA long read effect size data table Posting this under the heading it deserves: Waist circumference technique and its repeatability Everything below is what sits behind that. An honest uncertainty about Waist circumference technique rather than…	+23	27	5.9k	21h
Coming back to: Column chemistry choices for a 40-residue peptide Analytics › HPLC & UHPLC peak integration system suitability gradient method data table On the subject in the title: Column chemistry choices for a 40-residue peptide Working notes rather than a conclusion. Column chemistry choices — I have the observation and I do not trust my interpretation of…		2	43k	16mo
Insulin combinations and hypoglycaemia risk Practice › Interactions metformin needs a source hypoglycaemia insulin Closed On the subject in the title: Insulin combinations and hypoglycaemia risk Working notes rather than a conclusion. I was wrong about insulin combinations and hypoglycaemia risk in a thread last spring and I…	+18	22	7.8k	13mo
People with a low starting BMI: where the evidence stops Clinical › Special populations pregnancy & planning chronic kidney disease older adults Posting this under the heading it deserves: People with a low starting BMI: where the evidence stops Everything below is what sits behind that. Asking about a population rather than about a person. The…	+23	27	5.8k	19mo
Injection timing and sleep disruption Wellbeing › Sleep fatigue heart rate obstructive sleep apnoea Solved Posting this under the heading it deserves: Injection timing and sleep disruption Everything below is what sits behind that. Injection timing and sleep disruption: setting out the arithmetic in full, because…		3	39k	3h
How to bring a laboratory report to an appointment usefully Clinical › Bloodwork thyroid function lipase & amylase lipid panel eGFR & renal function How to bring a laboratory report to an appointment usefully — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about bring a laboratory directly, because I have…		2	41k	14mo
Distinguishing a red flag from an inconvenience Sourcing › Red flags mislabelling documentation quality moderation underdosing Solved Distinguishing a red flag from an inconvenience — setting out what I have, and where I think it stops being reliable. Something about distinguishing a red flag does not reconcile and I would like a second…		2	38k	6mo
Sulfonylureas: the interaction most worth taking seriously — what changed since Practice › Interactions metformin delayed gastric emptying hypoglycaemia insulin On the subject in the title: Sulfonylureas: the interaction most worth taking seriously — what changed since Working notes rather than a conclusion. What changes if the standard account of Sulfonylureas is…	+3	7	35k	1d
Coming back to: Oxidation pathways for methionine and tryptophan Analytics › Impurities & related substances HPLC counter-ion content water content data table Oxidation pathways for methionine and tryptophan Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here about Oxidation pathways for…	+1	5	36k	15mo
Coming back to: Bariatric surgery history: altered anatomy, altered expectations Clinical › Special populations adolescents disordered eating older adults Pinned Bariatric surgery history: altered anatomy, altered expectations Writing it up because I had to work it out twice and would rather nobody else did. Bariatric surgery history — I have the observation and I do…		2	38k	15mo
[2026 update] A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports batch & lot numbers third-party testing documentation quality certificate of analysis On the subject in the title: A report I filed that turned out to be wrong, and the correction Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+15	19	18k	2d
Publication bias detection and its low power — does this still hold? Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. Collecting what is known about Publication…	+24	28	2.4k	3mo
Follow-up: Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club randomised trial risk of bias effect size journal club Closed On the subject in the title: Journal club: the retatrutide phase 2 obesity paper Working notes rather than a conclusion. A follow-up question about retatrutide phase 2 obesity paper that I did not know to ask…	+20	24	8.7k	16mo
Why "add 2 mL" is not an instruction Practice › Reconstitution reconstitution worked example syringe units dead volume The question in the title: Why "add 2 mL" is not an instruction I will give what I have already checked below so nobody repeats it. Practical question with the units stated, because I have seen how quickly…	+23	27	3.5k	6mo
Lean mass preservation: what the evidence supports Outcomes › Body composition lean mass loss bioimpedance DXA Lean mass preservation: what the evidence supports Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on lean mass preservation,…	+23	27	347	14mo
Two sessions a week versus four: what the evidence supports — a second dataset Nutrition & Training › Resistance training lean mass loss fatigue DXA Two sessions a week versus four: what the evidence supports — a second dataset — setting out what I have, and where I think it stops being reliable. Reporting rather than asking, and the method is stated so…	+28	32	579	2y
Micronutrient status when intake falls substantially Clinical › Bloodwork lipase & amylase thyroid function lipid panel HbA1c Solved Wiki Closed On the subject in the title: Micronutrient status when intake falls substantially Working notes rather than a conclusion. Posting a small dataset on micronutrient status. It is mine, it is uncontrolled, and…	+26	30	367	11mo
Introducing myself and asking whether my planned first topic belongs anywhere — does this still hold? Start Here › Welcome trust levels onboarding guidelines Solved Closed Introducing myself and asking whether my planned first topic belongs anywhere — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Checking my…		2	36k	2mo