Ranked by engagement

Top topics — this year page 11

Ranked by replies, likes and views over this year, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,076 topics · page 11 of 14

Topic	Participants	Replies	Views	Activity
Revisiting: Liver enzymes drifting down and what that usually means Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase On the subject in the title: Revisiting: Liver enzymes drifting down and what that usually means Working notes rather than a conclusion. A methods question rather than a substantive one, about Liver enzymes…	+55	61	39k	3h
Designing a personal experiment that could change your mind — one year on Research Methods › N-of-1 designs effect size data table worked example Designing a personal experiment that could change your mind — one year on — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on…	+74	80	17k	2d
Liver enzymes drifting down and what that usually means Clinical › Bloodwork HbA1c liver enzymes eGFR & renal function Solved Closed Liver enzymes drifting down and what that usually means — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about liver enzymes drifting.…	+66	72	12k	4mo
What to bring: records that a clinician can actually use — a second dataset Clinical › Prescriber conversations telehealth beginner friendly prior authorisation What to bring: records that a clinician can actually use — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. A question about how to describe something…	+80	86	5.6k	3h
Pinch or no pinch, and how needle length changes the answer — the long version Practice › Administration injection site rotation injection site reaction missed dose aseptic technique On the subject in the title: Pinch or no pinch, and how needle length changes the answer — the long version Working notes rather than a conclusion. A narrow question about Pinch, deliberately narrow, because…	+75	79	1.5k	1mo
Micro-titration: a disputed topic, argued properly — one year on Practice › Dosing & titration dose reduction missed dose semaglutide Posting this under the heading it deserves: Micro-titration: a disputed topic, argued properly — one year on Everything below is what sits behind that. Reading back through what has been written here about…	+63	68	35k	1d
Prescription requirements and telehealth models — a second dataset Sourcing › Regulatory compounding EMA MHRA personal import On the subject in the title: Prescription requirements and telehealth models — a second dataset Working notes rather than a conclusion. Posting a small dataset on Prescription requirements and telehealth…	+87	94	1.1k	21d
Pinch or no pinch, and how needle length changes the answer — what changed since Practice › Administration missed dose aseptic technique injection site rotation Solved Posting this under the heading it deserves: Pinch or no pinch, and how needle length changes the answer — what changed since Everything below is what sits behind that. What changes if the standard account of…	+58	62	16k	1d
Why catalogue breadth is not evidence of anything — what changed since Compounds › Other compounds custom synthesis mislabelling needs a source research use only Asking directly, because I could not find a straight answer: Why catalogue breadth is not evidence of anything — what changed since What changes if the standard account of catalogue breadth is wrong? I ask…	+62	66	26k	10mo
Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators worked example site feedback syringe units concentration maths Bug report: the reconstitution calculator and a rounding edge case — setting out what I have, and where I think it stops being reliable. Posting the calculation with the inputs, so that somebody can disagree…	+68	72	28k	4mo
Does a peptide degrade silently, with no visual change? Practice › Storage & stability beyond-use date cold chain temperature excursion freeze-thaw Solved Does a peptide degrade silently, with no visual change? I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of peptide is wrong? I…	+73	79	1.3k	1d
Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides needs a source BPC-157 preprint Solved Why the absence of controlled human data on BPC-157 matters more than people admit — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to know what people…	+60	66	16k	1d
Follow-up: Comparing two chromatograms from different laboratories, properly Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Comparing two chromatograms from different laboratories, properly — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+62	67	12k	9h
A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipid panel HbA1c liver enzymes lipase & amylase Posting this under the heading it deserves: A single out-of-range value on an otherwise normal panel Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+70	75	20k	6d
Revisiting: Drawing up with one needle and injecting with another Practice › Administration subcutaneous injection injection site reaction needle gauge & length missed dose Revisiting: Drawing up with one needle and injecting with another Writing it up because I had to work it out twice and would rather nobody else did. A practical question that I suspect has a boring answer,…	+76	83	1.1k	4mo
Search filters: what is missing Meta › Site feedback site feedback moderation guidelines Search filters: what is missing — setting out what I have, and where I think it stops being reliable. Search filters — I have the observation and I do not trust my interpretation of it, so I am posting the…	+72	84	15k	3d
Fatigue in the first month: how much is the drug and how much is intake — what changed since Practice › Side effects nausea constipation hair shedding Closed Fatigue in the first month: how much is the drug and how much is intake — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Something changed and I would…	+77	82	1.2k	11mo
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Compounds › Semaglutide STEP programme SELECT trial randomised trial type 2 diabetes Under review On the subject in the title: Semaglutide versus liraglutide head to head: reading STEP 8 carefully Working notes rather than a conclusion. I would like to disagree carefully with the settled view on…	+72	81	1.5k	9mo
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators concentration maths site feedback syringe units On the subject in the title: Bug report: the reconstitution calculator and a rounding edge case Working notes rather than a conclusion. Posting the calculation with the inputs, so that somebody can disagree…	+58	63	24k	5mo
Subgroup analyses: pre-specified versus discovered — a second dataset Evidence › Trials open label discontinuation & dropout estimand randomised trial On the subject in the title: Subgroup analyses: pre-specified versus discovered — a second dataset Working notes rather than a conclusion. Posting a small dataset on Subgroup analyses. It is mine, it is…	+71	79	906	3mo
Sleep quality changes during weight loss — what changed since Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Sleep quality changes during weight loss — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Sleep quality changes…	+68	74	10k	8mo
Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues cagrilintide amylin analogues cagrisema Nausea profile of amylin analogues compared with GLP-1 agonists Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin nausea profile of…	+70	76	3k	4mo
Prior authorisation: what the criteria usually require — a second dataset Access › Insurance & coverage prior authorisation insurance formulary appeals Posting this under the heading it deserves: Prior authorisation: what the criteria usually require — a second dataset Everything below is what sits behind that. Posting a small dataset on Prior authorisation.…	+67	74	19k	21h
Completing a dose with a second syringe, and the dead-volume arithmetic Practice › Administration aseptic technique subcutaneous injection missed dose needle gauge & length Wiki Posting this under the heading it deserves: Completing a dose with a second syringe, and the dead-volume arithmetic Everything below is what sits behind that. I have read the maintained page on this and I…	+65	76	7.4k	1d
Cost per delivered dose, which is the number that matters Access › Pricing cost per milligram data table compounding formulary Solved Cost per delivered dose, which is the number that matters — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this category…	+54	59	30k	4mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Clinical › Special populations older adults chronic kidney disease adolescents disordered eating Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Older adults, deliberately…	+64	69	15k	7mo
What pooling buys you and what it destroys Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. The question about pooling buys that I actually want answered is the…	+74	83	6.6k	8mo
Reporting a disappointing outcome, and why it belongs here Outcomes › Progress reports data table DXA effect size Closed Reporting a disappointing outcome, and why it belongs here Writing it up because I had to work it out twice and would rather nobody else did. Proposing that reporting a disappointing outcome deserves a…	+21	29	62k	10mo
A widely repeated interaction claim that turns out to be unsupported Practice › Interactions metformin hypoglycaemia delayed gastric emptying needs a source On the subject in the title: A widely repeated interaction claim that turns out to be unsupported Working notes rather than a conclusion. I was wrong about widely repeated interaction claim in a thread last…	+47	51	37k	3mo
Storing lyophilised material long term: what governs the shelf life Practice › Storage & stability temperature excursion cold chain freeze-thaw On the subject in the title: Storing lyophilised material long term: what governs the shelf life Working notes rather than a conclusion. I have spent a fortnight trying to pin storing lyophilised material…	+83	90	1k	5mo