Ranked by engagement

Top topics — this year page 9

Ranked by replies, likes and views over this year, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,076 topics · page 9 of 14

Topic	Participants	Replies	Views	Activity
Coming back to: Official shortage notices and what they authorise Access › Shortages FDA compounding shortage formulary Official shortage notices and what they authorise Writing it up because I had to work it out twice and would rather nobody else did. Official shortage notices — I have the observation and I do not trust my…	+85	92	5.5k	11mo
Personal or family history of medullary thyroid carcinoma — what changed since Safety › Contraindications pancreatitis thyroid C-cell question delayed gastric emptying Posting this under the heading it deserves: Personal or family history of medullary thyroid carcinoma — what changed since Everything below is what sits behind that. Asking about a contraindication as written…	+91	96	1.3k	25d
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long version Compounds › Tirzepatide SURMOUNT programme randomised trial effect size tirzepatide Closed On the subject in the title: Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long version Working notes rather than a conclusion. A narrow question about Tirzepatide in type 2…	+85	90	13k	7mo
[2026 update] How much of the diluent volume the powder itself displaces Practice › Reconstitution reconstitution worked example syringe units Wiki Closed The question in the title: How much of the diluent volume the powder itself displaces I will give what I have already checked below so nobody repeats it. Writing this out with the numbers in it, because…	+89	100	3.2k	8mo
Airline travel with a temperature-sensitive injectable — what changed since Devices › Cold chain cold chain storage temperature excursion Airline travel with a temperature-sensitive injectable — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Airline…	+89	95	5.3k	9mo
Second pass at: Programming during a large energy deficit Nutrition & Training › Resistance training fatigue lean mass loss DXA On the subject in the title: Second pass at: Programming during a large energy deficit Working notes rather than a conclusion. The question about Programming during a large energy that I actually want…	+94	100	1.2k	8mo
Seven-day rolling means and why weekly readings mislead — one year on Outcomes › Progress reports DXA data table long read Solved On the subject in the title: Seven-day rolling means and why weekly readings mislead — one year on Working notes rather than a conclusion. Asking about Seven-day rolling directly, because I have read four…	+78	88	16k	5mo
Choosing which test to pay for, given a fixed budget Sourcing › Independent verification third-party testing VendorInvestigate Medutest Janoshik Analytical On the subject in the title: Choosing which test to pay for, given a fixed budget Working notes rather than a conclusion. A question about how a record should be read rather than about a supplier. We have…	+60	70	49k	3mo
Asking a follow-up: new topic or new reply? Start Here › How to Ask worked example onboarding beginner friendly Solved Asking a follow-up: new topic or new reply? — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about asking a follow-up in one place, because it…	+68	73	40k	1d
Request: show the solution author in the topic list — what changed since Meta › Feature requests site feedback wiki post translation Request: show the solution author in the topic list — what changed since — setting out what I have, and where I think it stops being reliable. Bringing the figures rather than the impression, since a process…	+79	91	20k	3mo
What to include when your question involves a chromatogram Start Here › How to Ask guidelines beginner friendly worked example Solved What to include when your question involves a chromatogram I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+49	54	58k	6mo
Why the timeline is on the right and not the left Meta › Site feedback moderation site feedback guidelines Solved Why the timeline is on the right and not the left — that is the question, and I have not found it answered plainly anywhere I have looked. Something about timeline does not reconcile and I would like a second…	+67	73	19k	10mo
A widely repeated interaction claim that turns out to be unsupported — what changed since Practice › Interactions insulin hypoglycaemia metformin needs a source Solved A widely repeated interaction claim that turns out to be unsupported — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about widely repeated…	+89	94	5.9k	2h
Second pass at: Identical chromatograms across two different lots Sourcing › Red flags disputed mislabelling moderation Posting this under the heading it deserves: Second pass at: Identical chromatograms across two different lots Everything below is what sits behind that. Something about Identical chromatograms does not…	+81	93	13k	4mo
Micronutrient adequacy at low total intake Nutrition & Training › Protein & intake constipation fatigue lean mass loss Under review Micronutrient adequacy at low total intake — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on micronutrient adequacy, before collecting…	+93	99	5.8k	1mo
Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation linearity recovery precision & repeatability system suitability On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Working notes rather than a conclusion. Trying to establish the boundary conditions on…	+93	99	1.4k	6d
Anxiety in the first weeks: drug, situation, or both — what changed since Wellbeing › Mental health mood disordered eating beginner friendly Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did. The question about Anxiety that I actually want…	+88	95	4.5k	5mo
Coming back to: Over-dilution: when your dose falls below one readable graduation Practice › Reconstitution worked example dead volume syringe units bacteriostatic water Over-dilution: when your dose falls below one readable graduation Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…	+90	97	1.1k	7mo
Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses heterogeneity risk of bias meta-analysis effect size Posting this under the heading it deserves: Heterogeneity as information rather than as a nuisance Everything below is what sits behind that. An honest uncertainty about heterogeneity rather than a disguised…	+88	95	1.2k	6mo
Hair shedding at month three: mechanism and time course — the long version Practice › Side effects nausea delayed gastric emptying vomiting Hair shedding at month three: mechanism and time course — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+50	54	50k	1d
Coming back to: When "no data" is the complete and final answer Compounds › Other compounds research use only needs a source custom synthesis When "no data" is the complete and final answer I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about the compound itself rather than about a trial of it. I…	+77	82	12k	11mo
Type 2 diabetes and the largest part of the evidence base Clinical › Comorbidities chronic kidney disease obstructive sleep apnoea type 2 diabetes MASH / hepatic steatosis Posting this under the heading it deserves: Type 2 diabetes and the largest part of the evidence base Everything below is what sits behind that. Trying to work out what would count as evidence on type 2…	+81	89	2.9k	3mo
Transporting a vial for a weekend away — a second dataset Practice › Storage & stability storage cold chain beyond-use date Transporting a vial for a weekend away — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Transporting a vial. It is mine, it is…	+74	84	5.1k	1mo
Reading a preclinical wound-healing model and its relevance to a human tendon — a second dataset Compounds › Repair & healing peptides observational data preprint BPC-157 Reading a preclinical wound-healing model and its relevance to a human tendon — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Reading a…	+64	69	27k	4mo
Five questions in one post gets you one answer — how to split them Start Here › How to Ask guidelines site feedback worked example Closed On the subject in the title: Five questions in one post gets you one answer — how to split them Working notes rather than a conclusion. A narrow question about five questions, deliberately narrow, because the…	+85	90	1k	2mo
Travel coolers and how long they really hold Devices › Cold chain temperature excursion storage freeze-thaw On the subject in the title: Travel coolers and how long they really hold Working notes rather than a conclusion. A narrow question about travel coolers, deliberately narrow, because the broad version has…	+78	84	14k	12mo
Documentation that materially improves an appeal's chances Access › Insurance & coverage insurance appeals formulary prior authorisation Documentation that materially improves an appeal's chances — setting out what I have, and where I think it stops being reliable. An honest uncertainty about documentation rather than a disguised assertion. I…	+93	98	3.6k	8mo
Reading a rodent study on a secretagogue without over-extrapolating — the long version Compounds › Secretagogues & GH axis observational data tesamorelin ipamorelin needs a source Reading a rodent study on a secretagogue without over-extrapolating — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Reading a rodent study,…	+59	66	30k	4h
Pen mechanics when the cartridge is nearly empty — does this still hold? Devices › Pens & autoinjectors storage subcutaneous injection missed dose dead volume Asking directly, because I could not find a straight answer: Pen mechanics when the cartridge is nearly empty — does this still hold? Pen mechanics — I have the observation and I do not trust my…	+37	47	61k	6mo
Why a compound being unapproved is not the same as being illegal to possess Sourcing › Regulatory FDA MHRA research use only EMA Why a compound being unapproved is not the same as being illegal to possess I have a specific reason for asking rather than idle curiosity, and the context is below. Collecting what is known about compound…	+72	78	23k	3mo