Ranked by engagement

Top topics — this year page 2

Ranked by replies, likes and views over this year, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,076 topics · page 2 of 14

Topic	Participants	Replies	Views	Activity
Managing an unplanned gap in supply — what changed since Access › Shortages compounding FDA formulary On the subject in the title: Managing an unplanned gap in supply — what changed since Working notes rather than a conclusion. What changes if the standard account of Managing an unplanned gap is wrong? I ask…	+114	124	54k	8mo
Tracking a preprint to publication: a worked example Evidence › Preprints preprint risk of bias needs a source Tracking a preprint to publication: a worked example Writing it up because I had to work it out twice and would rather nobody else did. A preprint question rather than a question about the finding in it. The…	+133	147	15k	7mo
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Posting a series rather than a conclusion, with the method first.…	+109	125	42k	10h
A ten-fold dose error caught before injection — one year on Devices › Syringes & needles dead volume needle gauge & length subcutaneous injection syringe units On the subject in the title: A ten-fold dose error caught before injection — one year on Working notes rather than a conclusion. Two things I would like separated before anyone answers on ten-fold dose error…	+151	157	9.4k	12mo
Trifluoroacetate content and its consequences Analytics › Impurities & related substances water content data table forced degradation counter-ion content Trifluoroacetate content and its consequences — setting out what I have, and where I think it stops being reliable. What changes if the standard account of trifluoroacetate content is wrong? I ask because I…	+123	134	31k	5mo
Racemisation and why it is invisible to a mass measurement Analytics › Impurities & related substances counter-ion content endotoxin testing HPLC Closed Posting this under the heading it deserves: Racemisation and why it is invisible to a mass measurement Everything below is what sits behind that. A question about racemisation that I think has a definite…	+120	127	41k	1mo
Request: a diff view for wiki revisions — the long version Meta › Feature requests translation site feedback wiki post Solved Posting this under the heading it deserves: Request: a diff view for wiki revisions — the long version Everything below is what sits behind that. A narrow question about diff view for wiki revisions,…	+90	104	61k	6mo
Substitution between formats during a shortage Access › Shortages compounding FDA formulary shortage Solved Closed On the subject in the title: Substitution between formats during a shortage Working notes rather than a conclusion. The question about substitution between formats that I actually want answered is the second…	+114	123	47k	7mo
[2026 update] What steady state means for the decision to escalate Practice › Dosing & titration tirzepatide worked example semaglutide missed dose The question in the title: What steady state means for the decision to escalate I will give what I have already checked below so nobody repeats it. Asking about steady state directly, because I have read four…	+127	137	32k	8mo
A reconstituted vial's beyond-use date and the reasoning behind common figures Practice › Storage & stability temperature excursion storage freeze-thaw Posting this under the heading it deserves: A reconstituted vial's beyond-use date and the reasoning behind common figures Everything below is what sits behind that. I have read the maintained page on this…	+125	129	45k	2mo
Reconstituting a multi-strength kit without mixing yourself up Practice › Reconstitution reconstitution concentration maths syringe units Wiki Reconstituting a multi-strength kit without mixing yourself up Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin reconstituting a…	+108	123	30k	11mo
Follow-up: Why the titration planner refuses to produce a schedule below a floor Data & Tools › Calculators worked example syringe units site feedback The question in the title: Why the titration planner refuses to produce a schedule below a floor I will give what I have already checked below so nobody repeats it. A follow-up question about titration…	+120	146	14k	10mo
Thyroid function tests during substantial weight change Clinical › Bloodwork lipase & amylase HbA1c liver enzymes eGFR & renal function Closed Posting this under the heading it deserves: Thyroid function tests during substantial weight change Everything below is what sits behind that. I was wrong about thyroid function tests during substantial in a…	+136	149	3.3k	8mo
[2026 update] Charge states for a 4 kDa peptide, worked through Analytics › Mass spectrometry counter-ion content MALDI-TOF high-resolution MS LC-MS On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide has a…	+116	135	31k	3mo
Micro-titration: a disputed topic, argued properly Practice › Dosing & titration titration dose reduction worked example tirzepatide Solved Wiki Micro-titration: a disputed topic, argued properly Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on…	+99	110	61k	2d
[2026 update] What the GIP component of tirzepatide is thought to contribute, and how confident we can be Compounds › Tirzepatide SURPASS programme randomised trial effect size Under review The question in the title: What the GIP component of tirzepatide is thought to contribute, and how confident we can be I will give what I have already checked below so nobody repeats it. I would like to know…	+109	124	31k	10mo
Promotion criteria, and the one that stops most nominations — the long version Documentation › Doc review promoted to docs maintainership citation check wiki post On the subject in the title: Promotion criteria, and the one that stops most nominations — the long version Working notes rather than a conclusion. A narrow question about Promotion criteria, deliberately…	+130	143	7.2k	6mo
Revisiting: The report format the maintainers ask for, and why each field is there Sourcing › Vendor reports batch & lot numbers Janoshik Analytical documentation quality third-party testing Posting this under the heading it deserves: Revisiting: The report format the maintainers ask for, and why each field is there Everything below is what sits behind that. Structured report rather than an…	+100	108	57k	1d
[2026 update] Storing lyophilised material long term: what governs the shelf life Practice › Storage & stability beyond-use date freeze-thaw cold chain cloudy or discoloured solution Storing lyophilised material long term: what governs the shelf life — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on Storing…	+122	133	35k	1mo
Vomiting: when it is expected and when it is a reason to stop Practice › Side effects constipation nausea fatigue Solved Posting this under the heading it deserves: Vomiting: when it is expected and when it is a reason to stop Everything below is what sits behind that. Reporting something rather than asking about it, in case…	+116	124	43k	7mo
Alcohol: what is documented and what is folklore Practice › Interactions metformin insulin delayed gastric emptying Posting this under the heading it deserves: Alcohol: what is documented and what is folklore Everything below is what sits behind that. Alcohol, and specifically the version of it that the documentation does…	+120	134	11k	2d
Tracking a shortage from primary sources rather than rumour Access › Shortages shortage FDA formulary Tracking a shortage from primary sources rather than rumour — setting out what I have, and where I think it stops being reliable. An honest uncertainty about tracking a shortage rather than a disguised…	+121	126	35k	13h
A parcel that arrived warm: a decision process, not a verdict Practice › Storage & stability cold chain beyond-use date storage freeze-thaw Solved A parcel that arrived warm: a decision process, not a verdict Writing it up because I had to work it out twice and would rather nobody else did. Asking about the failure mode rather than the procedure,…	+130	140	12k	8mo
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Practice › Reconstitution syringe units worked example reconstitution bacteriostatic water Solved A 5 mg vial and a 0.25 mg dose: the arithmetic in full Writing it up because I had to work it out twice and would rather nobody else did. 5 mg vial: setting out the arithmetic in full, because I have had to…	+124	141	16k	2d
[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Devices › Syringes & needles dead volume needle gauge & length subcutaneous injection Solved On the subject in the title: 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Working notes rather than a conclusion. A follow-up question about 0.3 ml versus 0.5 ml that I did not know to ask the…	+108	124	27k	2mo
The 2.5 mg starting dose is not a therapeutic dose — why that matters Compounds › Tirzepatide SURPASS programme SURMOUNT programme effect size Solved The 2.5 mg starting dose is not a therapeutic dose — why that matters Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about 2.5 mg starting dose that I…	+119	136	5.6k	2mo
Insurance and replacement policies, compared Sourcing › Logistics temperature excursion cold chain customs shipping Solved On the subject in the title: Insurance and replacement policies, compared Working notes rather than a conclusion. I have spent a fortnight trying to pin insurance and replacement policies down and I want to…	+115	122	17k	17h
New subcategory: rationale and scope Meta › Announcements trust levels site feedback moderation guidelines On the subject in the title: New subcategory: rationale and scope Working notes rather than a conclusion. Proposing that new subcategory deserves a maintained page rather than a recurring topic, and drafting…	+123	138	13k	9mo
Specification in the result column: why that is a meaningful error Analytics › COA interpretation reference standards amino acid analysis certificate of analysis batch & lot numbers Under review Closed Posting this under the heading it deserves: Specification in the result column: why that is a meaningful error Everything below is what sits behind that. A documentation question rather than an analytical…	+107	129	41k	5mo
Grapefruit: why this class is not the class that cares Practice › Interactions needs a source hypoglycaemia metformin delayed gastric emptying Grapefruit: why this class is not the class that cares Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about grapefruit in a thread last spring and I would like…	+126	139	4k	4mo