Ranked by engagement

Top topics — this month page 8

Ranked by replies, likes and views over this month, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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374 topics · page 8 of 13

Topic	Participants	Replies	Views	Activity
Coming back to: Swirling versus inverting versus leaving it alone Practice › Reconstitution reconstitution concentration maths syringe units Solved Swirling versus inverting versus leaving it alone Writing it up because I had to work it out twice and would rather nobody else did. Swirling versus inverting versus leaving — I have the observation and I do…	+20	24	16k	26d
Follow-up: The retatrutide phase 2 obesity paper, read closely Compounds › Retatrutide retatrutide randomised trial preprint effect size The retatrutide phase 2 obesity paper, read closely — setting out what I have, and where I think it stops being reliable. A follow-up question about retatrutide phase 2 obesity paper that I did not know to…	+19	23	16k	2d
Tirzepatide storage and stability: what is published versus what is assumed Compounds › Tirzepatide SURPASS programme randomised trial SURMOUNT programme effect size On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Asking about tirzepatide storage and stability directly,…	+17	21	17k	12d
Conditions that change the calculus rather than forbidding it Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying Conditions that change the calculus rather than forbidding it Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of conditions is wrong? I…	+28	32	6.1k	1d
Follow-up: Reconciling a label claim with a content assay Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Reconciling a label claim with a content assay Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Reconciling a label claim that I did not know to…	+26	30	6.5k	14d
Composite endpoints and the component doing the work Evidence › Trials randomised trial surrogate endpoints open label discontinuation & dropout Solved Under review Composite endpoints and the component doing the work Writing it up because I had to work it out twice and would rather nobody else did. Collecting what is known about composite endpoints in one place, because…	+3	7	33k	13h
A calculator that gives a right answer to the wrong question Data & Tools › Calculators concentration maths worked example site feedback syringe units Posting this under the heading it deserves: A calculator that gives a right answer to the wrong question Everything below is what sits behind that. Posting the calculation with the inputs, so that somebody…	+32	36	1.9k	17h
About the Resistance training category Nutrition & Training › Resistance training lean mass loss fatigue DXA Pinned Wiki Programming while losing weight quickly, realistic expectations, and recovery. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…		4	40k	17d
What steady state means for the decision to escalate Practice › Dosing & titration semaglutide titration tirzepatide missed dose Solved What steady state means for the decision to escalate — that is the question, and I have not found it answered plainly anywhere I have looked. A question about steady state that I think has a definite answer,…	+31	35	2k	1d
Revisiting: Body image changing more slowly than the body Wellbeing › Mental health disordered eating mood beginner friendly Solved Posting this under the heading it deserves: Revisiting: Body image changing more slowly than the body Everything below is what sits behind that. What changes if the standard account of Body image is wrong? I…	+5	9	28k	8h
Preservatives: function, testing, and limits — one year on Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage bacteriostatic water Wiki On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Asking about Preservatives directly, because I have read four threads on it and…	+28	32	437	8d
A promotion I argued against, and why I lost — a second dataset Documentation › Doc review citation check promoted to docs wiki post A promotion I argued against, and why I lost — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on promotion. It is mine, it is…	+3	7	32k	12h
[2026 update] Waist circumference technique and its repeatability Outcomes › Progress reports DXA long read effect size data table Posting this under the heading it deserves: Waist circumference technique and its repeatability Everything below is what sits behind that. An honest uncertainty about Waist circumference technique rather than…	+23	27	5.9k	21h
Injection timing and sleep disruption Wellbeing › Sleep fatigue heart rate obstructive sleep apnoea Solved Posting this under the heading it deserves: Injection timing and sleep disruption Everything below is what sits behind that. Injection timing and sleep disruption: setting out the arithmetic in full, because…		3	39k	3h
Sulfonylureas: the interaction most worth taking seriously — what changed since Practice › Interactions metformin delayed gastric emptying hypoglycaemia insulin On the subject in the title: Sulfonylureas: the interaction most worth taking seriously — what changed since Working notes rather than a conclusion. What changes if the standard account of Sulfonylureas is…	+3	7	35k	1d
[2026 update] A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports batch & lot numbers third-party testing documentation quality certificate of analysis On the subject in the title: A report I filed that turned out to be wrong, and the correction Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+15	19	18k	2d
Revisiting: Taste changes and food aversion, reported and discussed Practice › Side effects nausea vomiting constipation Revisiting: Taste changes and food aversion, reported and discussed Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…	+20	25	4.3k	1d
Why chargeback is not the safety net people assume Sourcing › Payments research use only payments documentation quality Solved Asking directly, because I could not find a straight answer: Why chargeback is not the safety net people assume Asking about the record rather than the transfer. Every order leaves a trail: an order…	+22	26	2.5k	2d
A pooled estimate that changed when one trial was added Evidence › Meta-analyses meta-analysis publication bias effect size Solved A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. I was wrong about pooled estimate in a thread last spring and I would like to…	+24	28	3.5k	2d
Why catalogue breadth is not evidence of anything Compounds › Other compounds research use only needs a source custom synthesis Under review Why catalogue breadth is not evidence of anything I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of catalogue breadth is wrong?…		2	38k	2d
Second pass at: Cost versus information: making the trade-off explicitly Analytics › Home & field testing third-party testing documentation quality ELISA Posting this under the heading it deserves: Second pass at: Cost versus information: making the trade-off explicitly Everything below is what sits behind that. Posting a small dataset on Cost versus…	+23	27	6.1k	22h
Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? Compounds › Semaglutide type 2 diabetes randomised trial semaglutide SELECT trial Solved Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in the first…	+5	9	30k	8d
Selection into a registry and what it does to the estimate — a second dataset Evidence › Study critique confounding risk of bias effect size disputed Solved Posting this under the heading it deserves: Selection into a registry and what it does to the estimate — a second dataset Everything below is what sits behind that. Posting a small dataset on Selection. It is…	+28	32	1.3k	1d
Why oral semaglutide needs an absorption enhancer at all — one year on Compounds › Oral incretins randomised trial SOUL trial oral semaglutide PIONEER programme Why oral semaglutide needs an absorption enhancer at all — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. Reading back through what has been written here…	+11	15	17k	24d
Sleep quality changes during weight loss Wellbeing › Sleep heart rate obstructive sleep apnoea fatigue On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. Asking about sleep quality changes during weight on behalf of the question I keep seeing asked…	+27	31	555	5h
Gradient steepness and apparent purity: a worked comparison — the long version Analytics › HPLC & UHPLC HPLC system suitability gradient method Gradient steepness and apparent purity: a worked comparison — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Gradient steepness and apparent…		2	32k	1d
Shoulders, tangent skims, and defensible integration Analytics › HPLC & UHPLC peak integration UV & DAD detection HPLC gradient method Posting this under the heading it deserves: Shoulders, tangent skims, and defensible integration Everything below is what sits behind that. Setting out an integration problem with the actual figures, because…	+16	20	11k	13h
Comparing documentation quality across the directory, tabulated Sourcing › Vendor reports third-party testing disputed Janoshik Analytical batch & lot numbers Comparing documentation quality across the directory, tabulated — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin comparing documentation quality…	+7	11	29k	19h
Priming a pen and whether the primed volume is wasted Devices › Pens & autoinjectors storage missed dose dead volume Solved Wiki Priming a pen and whether the primed volume is wasted Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin priming a pen down and I want to…	+19	23	1.3k	2d
Osteoarthritis and mechanical versus metabolic improvement Clinical › Comorbidities MASH / hepatic steatosis chronic kidney disease type 2 diabetes obstructive sleep apnoea Osteoarthritis and mechanical versus metabolic improvement Writing it up because I had to work it out twice and would rather nobody else did. Asking about osteoarthritis and mechanical versus metabolic…	+2	6	30k	12h