h.jansen

TL2 · Ibadan

Contributes reviews on supplier material. Based in Ibadan.

Joined 11 December 2024 · last posted 9d

79 posts, newest first. Showing up to 150.

Why the Start Here categories exist, and what they are not for Replied, post #11 · Start Here › Welcome · 18 Jul 2026 · 3 likes The category structure looks heavier than it is. There are twenty top-level categories and you will use three of them. Find those three, mute the rest for a month, and…
Substitution between formats during a shortage — what changed since Replied, post #15 · Access › Shortages · 15 Jul 2026 · 0 likes Pharmacy-level availability varies enormously during a shortage, so two honest accounts from the same city can be opposite. I would be glad to be shown a cleaner way of…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #44 · Practice › Dosing & titration · 7 Jul 2026 · 19 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
Journal club: what we got wrong in an earlier session Replied, post #58 · Evidence › Journal club · 6 Jul 2026 · 25 likes Seconded. It reads as careful rather than confident, which is the right register.
Reading order for a first week here, and what to skip until later — what changed since Replied, post #12 · Start Here › Welcome · 5 Jul 2026 · 23 likes Right — I had this wrong and I am glad to have read it before it mattered.
Lipid changes during rapid weight loss: the expected trajectory Replied, post #7 · Clinical › Bloodwork · 24 Jun 2026 · 6 likes Post #4 is the version of this I will quote in future. One addition. Glycaemic markers integrate over different periods. A point glucose and a longer-term marker…
Alcohol: what is documented and what is folklore Replied, post #69 · Practice › Interactions · 21 Jun 2026 · 3 likes Alcohol is not contraindicated in the labelling and it does irritate a stomach that is already emptying slowly. There is no published interaction study, and the…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #61 · Wellbeing › Sleep · 17 Jun 2026 · 9 likes Confirming post #60 from a second method, which matters more than confirming it from a second person. Marking my uncertainty on Sleep apnoea explicitly. I am confident…
Reading a home test result without over-claiming Replied, post #69 · Analytics › Home & field testing · 6 Jun 2026 · 0 likes Where a home observation and an independent result disagree, the independent one is measuring something more specific. That does not make the home observation useless —…
The most useful thing you learned here that was not the answer you came for Replied, post #48 · Lounge › Off topic · 6 Jun 2026 · 4 likes Agreed, and the corollary is that a place with no visible corrections is not a place with fewer errors. Someone will know this better than I do and I hope they say so.
Revisiting: The best-written scientific paper you have read Replied, post #9 · Lounge › Off topic · 31 May 2026 · 0 likes Politics and public policy: healthcare policy that affects access to these compounds is relevant here. Partisan politics is not.
Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #44 · Practice › Administration · 22 May 2026 · 3 likes Completing a dose is a question about a distribution, not about a value, and treating it as a value is what produces the confident wrong answers.
Measurement error in home scales, with a worked standard deviation — the long version Replied, post #103 · Research Methods › Statistics · 13 May 2026 · 0 likes Measurement error in home scales has been discussed here with more heat than it deserves, mostly because two definitions have been in play the whole time.
[2026 update] Waist circumference technique and its repeatability Replied, post #6 · Outcomes › Progress reports · 28 Apr 2026 · 29 likes Right — I had this wrong and I am glad to have read it before it mattered.
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #111 · Analytics › Mass spectrometry · 24 Apr 2026 · 6 likes Confirming post #110 from a second method, which matters more than confirming it from a second person. My understanding of Charge states is a few years old and may have…
Converting between mg/mL and units per dose, both directions — the long version Replied, post #97 · Practice › Reconstitution · 24 Apr 2026 · 3 likes Swirling until fully clear before drawing is worth the extra minute. A partially dissolved preparation is not uniform and the first dose out of it is not the same as…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset Replied, post #40 · Sourcing › Independent verification · 19 Apr 2026 · 2 likes Post #39 and I disagree about the size of the effect, not about the direction. Where an independent figure and a declared figure differ by less than method…
Forced degradation studies: designing one that is informative Replied, post #36 · Analytics › Method validation · 13 Apr 2026 · 0 likes Forced degradation studies looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.
Prediction intervals and why they are more honest than confidence intervals Replied, post #9 · Evidence › Meta-analyses · 4 Apr 2026 · 0 likes Why forest plots are more informative than pooled numbers: they show the variation across studies, which tells you whether the effect is consistent or heterogeneous. A…
Introducing myself: pharmacist, sceptic, reluctant participant — one year on Replied, post #83 · Lounge › Introductions · 16 Mar 2026 · 17 likes Hello. Fair warning that this place will change how you read a certificate, and that you will not be able to go back to accepting one at face value.
Five questions in one post gets you one answer — how to split them Replied, post #28 · Start Here › How to Ask · 10 Mar 2026 · 33 likes Arithmetic questions: write out the steps. "I have a 10 mg vial, I added 2 mL, I want a 0.25 mg dose, and I get this number for the syringe mark" is answerable. "How…
Foaming during reconstitution and whether it matters — the long version Replied, post #57 · Practice › Reconstitution · 9 Mar 2026 · 0 likes Narrowing post #56, because the general version has more than one answer. Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and neither…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #8 · Compounds › Cagrilintide & amylin analogues · 15 Feb 2026 · 0 likes Adding a data point of agreement rather than a data point.
Coverage in the US: a map of the usual obstacles Replied, post #51 · Regional › North America · 14 Feb 2026 · 15 likes Picking up post #48: that is the part I would want checked first. Coverage decisions are made by individual payers and vary within the same jurisdiction. A denial from…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #74 · Documentation › Wiki requests · 6 Feb 2026 · 15 likes I had written a reply contradicting post #71 and deleted it. Here is what survived. Review cadence should be part of the proposal. A page about a fast-moving area needs…
Cardiovascular risk: reading the outcome trials as a set Replied, post #4 · Clinical › Comorbidities · 3 Feb 2026 · 28 likes Picking up the opening post: that is the part I would want checked first. Mechanistic reasoning about a population that was excluded from the trials has an unimpressive…
Trifluoroacetate content and its consequences Replied, post #16 · Analytics › Impurities & related substances · 24 Jan 2026 · 0 likes Post #14 put the caveat in the right place and I want to underline it. Acetate content: counter-ion content. Trifluoroacetate or acetate from the salt form of the…
Anaesthesia and elective surgery: the aspiration question Replied, post #3 · Practice › Interactions · 20 Jan 2026 · 0 likes That is the distinction I keep failing to hold on to. Written down now.
A plateau that disappeared when I changed how I measured Replied, post #9 · Outcomes › Progress reports · 18 Jan 2026 · 31 likes I would put moderate confidence on the mainstream reading of plateau and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #88 · Compounds › Semaglutide · 8 Jan 2026 · 0 likes Semaglutide's structure is a modified backbone with a C18 diacid attached through a spacer. The acylation is the reason for the long half-life and it is also the reason…
Packaging that arrived damaged: documenting it properly — a second dataset Replied, post #9 · Sourcing › Logistics · 18 Dec 2025 · 0 likes Adding the measurement that post #8 says would settle it. Document outcomes rather than forecasting them. A forecast in this category reads as reassurance and is not one.
Publishing an inconvenient result: a case study — the long version Replied, post #68 · Sourcing › Independent verification · 12 Dec 2025 · 0 likes Narrowing post #66, because the general version has more than one answer. A request rather than an answer: could whoever has the primary source for Publishing an…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #33 · Access › Pricing · 9 Dec 2025 · 0 likes Summarising the Price changes thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the correction to it, and the…
Where the integrator drew the baseline, and how much it moved the number Replied, post #21 · Analytics › HPLC & UHPLC · 20 Nov 2025 · 1 like I had written a reply contradicting post #20 and deleted it. Here is what survived. Change the wavelength and the proportions change even though the sample has not.…
Comparing two chromatograms from different laboratories, properly Replied, post #32 · Analytics › HPLC & UHPLC · 19 Nov 2025 · 26 likes Taking post #29 at face value and following it one step further. On integration: where the baseline is drawn matters more than most people realise. On a clean…
Pen dose counters: what a click does and does not guarantee Replied, post #13 · Devices › Pens & autoinjectors · 13 Nov 2025 · 9 likes Reusability: some pens are single-use (throw away after one injection). Others can be reused until empty. Confirm which type you have. Reusing a single-use pen is…
[2026 update] What steady state means for the decision to escalate Replied, post #38 · Practice › Dosing & titration · 8 Nov 2025 · 27 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose. I…
Titles that describe the question, not the situation Replied, post #133 · Start Here › How to Ask · 27 Oct 2025 · 14 likes Asking a follow-up: new topic or reply in the old one? If the answer depends on the previous post, reply. If it is a question that makes sense without the previous…
Moderation log format change Replied, post #5 · Meta › Announcements · 27 Oct 2025 · 13 likes Thank you for announcing it in advance rather than after. The number of places that do the reverse is remarkable. I would treat the number as indicative rather than as…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #107 · Compounds › Tirzepatide · 23 Oct 2025 · 0 likes On post #106 — agreed on the reasoning, with one qualification. A methods point on SURMOUNT-4 rather than a substantive one: if the comparison is not like for like, the…
A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #145 · Practice › Reconstitution · 15 Oct 2025 · 4 likes Before the thread moves on from 10 mg vial reconstituted three — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted…
Interim analyses and stopping rules Replied, post #2 · Evidence › Trials · 11 Oct 2025 · 18 likes Reframing interim analyses and stopping rules slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it…
The nausea timeline across the first four weeks, with a tabulated log Replied, post #131 · Practice › Side effects · 8 Oct 2025 · 28 likes Recognition and grading: nausea ranges from "noticeable" to "limiting". Constipation ranges from mild to severe. Having language to describe the magnitude helps you…
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #41 · Compounds › Oral incretins · 22 Sep 2025 · 14 likes Missed doses behave differently for a daily oral than for a weekly injection. With a short interval you are near a trough rather than perturbing a slowly moving…
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #7 · Evidence › Study critique · 12 Sep 2025 · 2 likes On Reverse causation the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.
Why the timeline is on the right and not the left Replied, post #64 · Meta › Site feedback · 5 Sep 2025 · 0 likes Seconding that. I would put solved-only in front of the sort control rather than behind it.
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Replied, post #34 · Practice › Dosing & titration · 31 Aug 2025 · 0 likes Dose equivalence between different incretin analogues is a weak concept. The molecules differ in structure, half-life, receptor selectivity, and in what has been…
Enforcement priorities versus written rules — does this still hold? Replied, post #18 · Sourcing › Regulatory · 19 Aug 2025 · 11 likes Compounding and pharmacy rules: some jurisdictions allow a pharmacy to compound a drug that is not on the market under specific conditions. The conditions are strict…
A request that was declined, and the reasoning — a second dataset Replied, post #27 · Documentation › Wiki requests · 8 Aug 2025 · 0 likes Answering the question post #25 raises rather than the one it answers. Request a new maintained page: if a question recurs, has a good marked solution, and contains a…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #151 · Compounds › Tirzepatide · 30 Jul 2025 · 0 likes I had written a reply contradicting post #148 and deleted it. Here is what survived. The honest answer on tirzepatide in type 2 diabetes is that it depends, and the…
Counter-ion content and its effect on measured mass Replied, post #86 · Analytics › Mass spectrometry · 8 Jul 2025 · 11 likes On post #84 — agreed on the reasoning, with one qualification. Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #80 · Wellbeing › Mental health · 30 Jun 2025 · 2 likes Nothing to add on the substance. Thank you for taking the question at face value.
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #56 · Clinical › Comorbidities · 21 Jun 2025 · 0 likes For anyone finding this later: the short answer on Cardiovascular risk is that it depends on one thing, and the rest of the thread is people identifying which thing.
A report I filed that turned out to be wrong, and the correction Replied, post #83 · Sourcing › Vendor reports · 2 Jun 2025 · 0 likes The maintainers will ask for missing fields rather than rejecting a report. Filling them in afterwards is normal and nobody minds.
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — what changed since Replied, post #73 · Practice › Reconstitution · 19 May 2025 · 0 likes Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and neither helps a peptide go into solution any faster than patience does. I would treat…
Sequence verification for an obscure compound: how it is done Replied, post #37 · Compounds › Other compounds · 17 May 2025 · 2 likes Filing a mild objection to the consensus on sequence verification. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.
Why plausible mechanism is not evidence of effect Replied, post #7 · Compounds › Repair & healing peptides · 27 Apr 2025 · 0 likes This follows post #6 rather than contradicting it. The absence of human trials means there is no established dose, no established interval and no established duration.…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #84 · Practice › Reconstitution · 20 Apr 2025 · 2 likes The decimal-point error: computing 5 mg / 2 mL as 0.25 mg/mL instead of 2.5 mg/mL is the most common arithmetic error in this subcategory. The habit that catches it:…
Why a pen's dose steps are fixed and what that costs you — one year on Replied, post #9 · Devices › Pens & autoinjectors · 13 Apr 2025 · 2 likes Storage instructions for a pen typically differ before and after first use, and the in-use period is the one people miss. It is on the carton. The number is defensible.…
What the published dose-response for semaglutide actually looks like above 2.4 mg — a… Replied, post #119 · Compounds › Semaglutide · 27 Mar 2025 · 17 likes Injection site does not appear to matter much for semaglutide exposure. The published comparisons of abdomen, thigh and upper arm found differences small enough to be…
Coverage for the indication versus for the drug Replied, post #4 · Access › Insurance & coverage · 18 Mar 2025 · 0 likes This is the sort of exchange that makes the archive worth searching.
Triple agonism: additive, synergistic, or neither? Replied, post #27 · Compounds › Retatrutide · 16 Mar 2025 · 15 likes I would rather this thread reach "we do not know" about triple agonism than reach a confident answer that nobody can support when asked.
Preparing for an appointment: one page, three questions Replied, post #11 · Clinical › Prescriber conversations · 16 Mar 2025 · 8 likes Answering the question post #9 raises rather than the one it answers. Take the actual numbers and the actual dates. A printed table beats a description and takes the…
A ten-fold dose error caught before injection Replied, post #7 · Devices › Syringes & needles · 8 Mar 2025 · 1 like Coming back to post #3, because the follow-up matters more than the original answer. The most useful thing anyone has posted about ten-fold dose error caught in this…
Review: a draft on reconstitution arithmetic, with objections Replied, post #48 · Documentation › Doc review · 7 Mar 2025 · 3 likes Careful with the language on draft on reconstitution arithmetic. "Not detected" and "not present" are different findings and the first is a statement about the method.
Pharmaceutical compounding rules, summarised from primary sources Replied, post #97 · Sourcing › Regulatory · 3 Mar 2025 · 14 likes Adding a reference point for pharmaceutical compounding rules. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #72 · Sourcing › Regulatory · 2 Mar 2025 · 0 likes Where I part company with post #69, and it is a narrow parting. An indication approved for one age range does not extend to another, and paediatric extensions are…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #11 · Evidence › Meta-analyses · 26 Jan 2025 · 0 likes The claim about Random versus fixed effects upthread is stronger than its source supports. I have read the source. The source says "associated with" and the post says…
Why mass spectrometry cannot tell you about an epimer Replied, post #27 · Analytics › Mass spectrometry · 14 Jan 2025 · 5 likes Second-hand on mass spectrometry, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.
What we do not know about retatrutide, listed explicitly Replied, post #52 · Compounds › Retatrutide · 11 Jan 2025 · 0 likes On post #50 — agreed on the reasoning, with one qualification. Retatrutide is investigational. Anything obtained outside a trial is by definition research-use-only…
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #60 · Compounds › Semaglutide · 10 Dec 2024 · 13 likes The arithmetic in post #57 is right; the assumption feeding it is the part to check. The mass figure differs between sources because of how the different entities…
Second pass at: Choosing a concentration on purpose rather than by accident Replied, post #40 · Practice › Reconstitution · 8 Dec 2024 · 22 likes This is the answer, and the reason it is the answer is the more useful part.
Tracking semaglutide's approved indications across jurisdictions, dated — does this… Replied, post #56 · Compounds › Semaglutide · 2 Dec 2024 · 0 likes That is a cleaner way of putting what I was circling around.
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #84 · Analytics › Method validation · 30 Nov 2024 · 0 likes The arithmetic in post #83 is right; the assumption feeding it is the part to check. A method that reports the same number for every lot is worth a second look. Real…
Requesting a page: what makes a good request — what changed since Replied, post #105 · Documentation › Wiki requests · 12 Oct 2024 · 0 likes On post #101 — agreed on the reasoning, with one qualification. Say what would make the page wrong. A page whose failure conditions are stated is much easier to review…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #87 · Access › Shortages · 12 Oct 2024 · 0 likes Planning around a known shortage window is easier than reacting to one, and the notices give advance warning more often than people expect.
When to suspect the method rather than the sample Replied, post #20 · Analytics › Method validation · 6 Oct 2024 · 8 likes The limit of quantitation determines what the impurity table can honestly contain. Peaks below it can be reported as detected and cannot be reported as a number. That…
Two sessions a week versus four: what the evidence supports — a second dataset Replied, post #30 · Nutrition & Training › Resistance training · 11 Jul 2024 · 3 likes The arithmetic in post #27 is right; the assumption feeding it is the part to check. Cardiovascular work has its own benefits and is not a substitute for a resistance…
Tracking a preprint to publication: a worked example — the long version Replied, post #2 · Evidence › Preprints · 20 May 2024 · 3 likes Coming back to the opening post, because the follow-up matters more than the original answer. Reading a preprint properly means doing some of the reviewer's job:…