d.bakker

TL2 · Faro

Contributes reviews on supplier material. Based in Faro.

Joined 12 May 2025 · last posted 3d

78 posts, newest first. Showing up to 150.

Revisiting: How this community labels and discusses unrefereed work Replied, post #34 · Evidence › Preprints · 25 Jul 2026 · 1 like How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.
Common supplements people ask about, assessed one at a time Replied, post #67 · Practice › Interactions · 19 Jul 2026 · 4 likes Answering the question post #63 raises rather than the one it answers. Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which…
What to bring: records that a clinician can actually use — a second dataset Replied, post #48 · Clinical › Prescriber conversations · 18 Jul 2026 · 16 likes Bringing a record of symptoms with dates and severities makes an assessment materially easier and is the single most useful preparation. Old habit: I write down the…
What I would want from a home test that does not exist yet Replied, post #35 · Analytics › Home & field testing · 12 Jul 2026 · 4 likes Taking post #34 at face value and following it one step further. Ultraviolet absorbance at 280 nanometres estimates concentration for peptides containing aromatic…
Seven-day rolling means and why weekly readings mislead Replied, post #8 · Outcomes › Progress reports · 10 Jul 2026 · 4 likes Nobody has said the unglamorous part of seven-day rolling yet, so: most of the variation is explained by things that are boring to write about and easy to check.
Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #95 · Safety › Contraindications · 2 Jul 2026 · 4 likes Agreed, and I will stop repeating the version of this I had been repeating.
Deletion sequences: expected mass shifts by residue — the long version Started this topic · Analytics › Impurities & related substances · 1 Jul 2026 · 3 likes On the subject in the title: Deletion sequences: expected mass shifts by residue — the long version Working notes rather than a conclusion. Deletion sequences keeps…
Ultrasound and skinfolds: operator dependence in practice Replied, post #27 · Outcomes › Body composition · 23 Jun 2026 · 18 likes Neither method is capable of detecting the month-to-month changes that people report detecting month to month. That is all I can say without guessing.
Follow-up: Reconciling a label claim with a content assay Replied, post #26 · Analytics › COA interpretation · 18 Jun 2026 · 1 like The distinction between release testing and characterisation is one industrial documents make and retail ones usually do not. It is the difference between "we tested…
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #116 · Compounds › Tirzepatide · 2 Jun 2026 · 0 likes Storage and stability: published data on licensed tirzepatide formulations exists and is worth reading directly rather than through summarised claims. Reconstituted…
Five questions in one post gets you one answer — how to split them Replied, post #82 · Start Here › How to Ask · 16 May 2026 · 4 likes I think the five questions question is answerable and has not been answered, which is a more optimistic position than most of this thread.
Second pass at: Metformin co-administration and additive GI effects Replied, post #98 · Practice › Interactions · 4 May 2026 · 1 like I would call the community position on Metformin co-administration likely rather than established, and I would be comfortable defending that hedge.
Validating a method you did not develop Replied, post #15 · Analytics › Method validation · 1 May 2026 · 16 likes Where I part company with post #11, and it is a narrow parting. Stability-indicating method: one that can separate a compound from its degradation products. Critical…
Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #4 · Documentation › Doc review · 23 Apr 2026 · 0 likes Draft on reconstitution arithmetic is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.
Second pass at: Where impurities in solid-phase peptide synthesis come from Replied, post #2 · Analytics › Impurities & related substances · 18 Apr 2026 · 4 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #37 · Devices › Syringes & needles · 17 Apr 2026 · 0 likes Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum. Not a…
Official shortage notices and what they authorise Replied, post #9 · Access › Shortages · 16 Apr 2026 · 7 likes Adding a data point of agreement rather than a data point.
The "under review" status pill and when a moderator applies it Replied, post #64 · Evidence › Preprints · 9 Apr 2026 · 31 likes Answering the question post #60 raises rather than the one it answers. Media coverage of preprints rarely mentions the status. That is where most of the downstream…
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still… Replied, post #13 · Compounds › Retatrutide · 8 Apr 2026 · 7 likes Coming back to post #11, because the follow-up matters more than the original answer. Retatrutide is investigational. Anything obtained outside a trial is by definition…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #127 · Pharmacology › Pharmacokinetics · 8 Apr 2026 · 0 likes Half-life determines how quickly concentration approaches steady state and does not determine what the steady-state concentration is. Dose and clearance determine that.…
Spike-and-recover accuracy for a peptide assay Replied, post #19 · Analytics › Method validation · 7 Apr 2026 · 16 likes Stability-indicating method: one that can separate a compound from its degradation products. Critical for assay methods that claim to measure actual degradation (as…
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #57 · Analytics › Mass spectrometry · 5 Apr 2026 · 6 likes Trifluoroacetate adducts are common in material purified with TFA and are one reason a mass spectrum from a peptide can look busier than expected.
Anaesthesia and elective surgery: the aspiration question Replied, post #70 · Practice › Interactions · 1 Apr 2026 · 15 likes My experience of anaesthesia and elective surgery contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's…
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #16 · Outcomes › Progress reports · 7 Mar 2026 · 0 likes Menstrual cycle: for people who menstruate, weight can shift by several pounds across the cycle due to fluid retention and other factors. Noting cycle phase when…
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #33 · Pharmacology › Pharmacokinetics · 4 Feb 2026 · 3 likes Post #31 put the caveat in the right place and I want to underline it. On Washout, the part that usually goes wrong is that the question is asked as though it has one…
Reading an interaction checker output critically Replied, post #107 · Practice › Interactions · 31 Jan 2026 · 14 likes Anticoagulant questions come up regularly and are the clearest case for professional advice rather than discussion, because the consequence of being wrong is not…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #26 · Clinical › Special populations · 28 Jan 2026 · 1 like Post #25 put the caveat in the right place and I want to underline it. I disagree with the framing of pregnancy and pregnancy planning above, and I think it is a…
Foaming during reconstitution and whether it matters — the long version Replied, post #11 · Practice › Reconstitution · 18 Jan 2026 · 7 likes Post #8 is right about the mechanism and I think understates the practical bit. Preservative effectiveness is tested against a defined microbial challenge under defined…
Cost per delivered dose, which is the number that matters Replied, post #37 · Access › Pricing · 8 Jan 2026 · 21 likes The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion. Not disagreeing with anyone above, just adding the bit I keep…
Second pass at: The topic list is dense — is that deliberate? Replied, post #38 · Meta › Site feedback · 7 Jan 2026 · 11 likes On topic list the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.
Revisiting: Language barriers in accessing a prescription abroad Replied, post #41 · Access › International · 5 Jan 2026 · 19 likes Picking up post #39: that is the part I would want checked first. The honest answer on Language barriers in accessing is that it depends, and the useful part is the…
Packaging that arrived damaged: documenting it properly — a second dataset Replied, post #15 · Sourcing › Logistics · 31 Dec 2025 · 0 likes On post #13 — agreed on the reasoning, with one qualification. Import restrictions by jurisdiction: what is legal to import for personal use varies enormously by…
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #70 · Wellbeing › Mental health · 31 Dec 2025 · 2 likes Post #69 is the version of this I will quote in future. One addition. Expectations set by other people's reported trajectories are a documented source of distress, and…
Substitution between formats during a shortage Replied, post #116 · Access › Shortages · 15 Dec 2025 · 0 likes Stockpiling in response to a shortage worsens it, which is true and is a poor argument to make to somebody who has run out.
The headache that turns out to be dehydration Replied, post #80 · Nutrition & Training › Hydration & electrolytes · 3 Dec 2025 · 0 likes Practical experience of headache, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #20 · Clinical › Bloodwork · 1 Dec 2025 · 6 likes Filing a mild objection to the consensus on panel. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #24 · Pharmacology › Pharmacokinetics · 23 Nov 2025 · 22 likes Volume of distribution: the theoretical volume the drug distributes into. For albumin-binding compounds, volume is reduced compared to drugs that do not bind protein.…
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Replied, post #34 · Sourcing › Regulatory · 17 Nov 2025 · 14 likes Acknowledging rather than arguing. The reasoning holds as far as I can follow it.
Older adults, sarcopenia risk, and the trade-off nobody quantifies Replied, post #31 · Clinical › Special populations · 14 Nov 2025 · 1 like Post #30 is right about the mechanism and I think understates the practical bit. On older adults I would separate what is worth knowing from what is worth acting on.…
The anatomy of a question that gets answered within an hour — the long version Replied, post #76 · Start Here › How to Ask · 9 Nov 2025 · 0 likes Where I part company with post #74, and it is a narrow parting. It is fine to say you cannot explain why you are asking. Nobody will press, and the technical part of…
Where to report an adverse event officially, by region — a second dataset Replied, post #107 · Safety › Adverse events · 8 Nov 2025 · 12 likes Reporting here and reporting to a national scheme are not alternatives. The second is what feeds safety surveillance. Happy to be corrected if someone holds better data…
Where impurities in solid-phase peptide synthesis come from Replied, post #17 · Analytics › Impurities & related substances · 1 Nov 2025 · 5 likes The honest answer on impurities in solid-phase peptide synthesis is that it depends, and the useful part is the list of what it depends on. Four items, in rough order…
Follow-up: What a seizure notice actually says Replied, post #31 · Sourcing › Logistics · 26 Oct 2025 · 0 likes Notice of a delay before the quoted window elapses is a materially different service experience from notice afterwards, and it is worth recording which happened.…
What a purity-only report leaves out Replied, post #53 · Sourcing › Independent verification · 20 Oct 2025 · 23 likes Two questions I would want answered before drawing anything from the purity-only data above: how were the cases selected, and what happened to the ones that dropped out.
Coming back to: Over-dilution: when your dose falls below one readable graduation Replied, post #66 · Practice › Reconstitution · 10 Oct 2025 · 10 likes Narrowing post #65, because the general version has more than one answer. The claim about Over-dilution upthread is stronger than its source supports. I have read the…
Documentation that appears only after payment Replied, post #35 · Sourcing › Red flags · 28 Sep 2025 · 0 likes Unresponsiveness: a supplier that does not reply to reasonable requests for documentation or clarification is showing you something about how they operate.
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #86 · Analytics › HPLC & UHPLC · 28 Sep 2025 · 0 likes A relative retention time against a known peak travels much better than an absolute one, and almost nobody reports it.
Reading a rodent study on a secretagogue without over-extrapolating Replied, post #47 · Compounds › Secretagogues & GH axis · 13 Sep 2025 · 28 likes Narrowing post #44, because the general version has more than one answer. CJC-1295 exists in two forms in circulation — with and without the drug affinity complex — and…
When a preprint is the best available evidence and we say so Replied, post #39 · Evidence › Preprints · 9 Aug 2025 · 0 likes Version numbers on a preprint server matter. Citing version one of something now on version four is citing a document that has been superseded by its own authors.…
A ten-fold dose error caught before injection Replied, post #78 · Devices › Syringes & needles · 7 Aug 2025 · 4 likes Small correction to my own earlier position on ten-fold dose error caught. I had the units the wrong way round, which changes the conclusion by an order of magnitude…
Coming back to: What published stability data actually covers, and what it does not Replied, post #95 · Practice › Storage & stability · 24 Jul 2025 · 21 likes This follows post #92 rather than contradicting it. Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter…
Coming back to: Official shortage notices and what they authorise Replied, post #60 · Access › Shortages · 17 Jul 2025 · 22 likes Where I part company with post #56, and it is a narrow parting. What I would want before treating Official shortage notices as settled: the method, the sample, and…
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #6 · Analytics › HPLC & UHPLC · 11 Jul 2025 · 16 likes Everything in post #2 holds. The case it does not cover is the one I have. Where the baseline is drawn is the least documented and most consequential choice in the…
Repeatability versus intermediate precision Replied, post #57 · Analytics › Method validation · 25 Jun 2025 · 33 likes Filing a mild objection to the consensus on repeatability versus intermediate precision. Mild because I might be wrong; an objection because nobody has addressed the…
Lipase elevation without symptoms: the interpretation problem — a second dataset Replied, post #16 · Clinical › Bloodwork · 17 Jun 2025 · 0 likes Adding the measurement that post #13 says would settle it. Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things. Bilirubin helps…
Needle changes between doses on a reusable pen — does this still hold? Replied, post #6 · Devices › Pens & autoinjectors · 13 Jun 2025 · 2 likes Adding the measurement that post #5 says would settle it. Disposal of a used pen is a sharps question even where the needle is retracted, and local rules vary more than…
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Replied, post #26 · Evidence › Journal club · 5 Jun 2025 · 9 likes The baseline characteristics table is the single most useful page for the questions that get asked here, because it tells you who the result applies to. Reading it…
Lipase elevation without symptoms: the interpretation problem — a second dataset Replied, post #9 · Clinical › Bloodwork · 4 Jun 2025 · 0 likes Post #8 is the version of this I will quote in future. One addition. A trend needs at least three points to be a trend. Two points are a line and a line through noise…
An orphaned page with no inbound links Replied, post #46 · Meta › Wiki maintenance · 28 May 2025 · 3 likes Scope creep: if a page is attempting too much, suggesting it split into multiple pages can improve clarity. Flagging that the sources on this are thinner than the…
Second pass at: Designing a personal experiment that could change your mind Replied, post #33 · Research Methods › N-of-1 designs · 20 May 2025 · 0 likes The useful distinction on Designing a personal experiment is between what was measured and what was inferred from it. Both end up in the same sentence and only one of…
DXA precision and the least significant change for lean mass — the long version Replied, post #52 · Outcomes › Body composition · 16 May 2025 · 1 like The arithmetic in post #51 is right; the assumption feeding it is the part to check. Bioelectric impedance analysis: less precise than DXA and strongly affected by…
Certificates issued by the seller versus by a laboratory Replied, post #36 · Analytics › COA interpretation · 8 Apr 2025 · 0 likes The distinction between release testing and characterisation is one industrial documents make and retail ones usually do not. It is the difference between "we tested…
Revisiting: Aggregate verification data across the directory, with caveats Replied, post #3 · Sourcing › Independent verification · 6 Feb 2025 · 1 like The claim about Aggregate verification data upthread is stronger than its source supports. I have read the source. The source says "associated with" and the post says…
Why the Start Here categories exist, and what they are not for — one year on Started this topic · Start Here › Welcome · 26 Jan 2025 · 60 likes Why the Start Here categories exist, and what they are not for — one year on I have a specific reason for asking rather than idle curiosity, and the context is below.…
Talking to a therapist about this specifically — does this still hold? Replied, post #5 · Wellbeing › Mental health · 13 Jan 2025 · 0 likes Noted, and thank you for writing it out rather than summarising it.
About the Wiki requests category Replied, post #7 · Documentation › Wiki requests · 23 Dec 2024 · 0 likes Requests for a page summarising a supplier are declined, because that is what the vendor documentation set is for and it has its own standards.
UK access routes, dated and sourced — a second dataset Replied, post #17 · Regional › UK & Ireland · 18 Dec 2024 · 0 likes Cross-border movement between the two jurisdictions is not the same as domestic movement within either, and the rules are published rather than inferred. The general…
Coming back to: When to suspect the method rather than the sample Replied, post #89 · Analytics › Method validation · 17 Dec 2024 · 13 likes I had written a reply contradicting post #87 and deleted it. Here is what survived. Reporting a result to more decimal places than the method's precision supports is a…
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #15 · Devices › Cold chain · 29 Nov 2024 · 5 likes Regional stock shortens the exposure window more effectively than any packing improvement, which is the practical argument for it beyond speed.
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #59 · Clinical › Special populations · 24 Nov 2024 · 26 likes Extrapolating a point estimate to somebody well outside the enrolled range should be described as an extrapolation every time it is done.
Follow-up: Recovery when intake is low: what to cut first Replied, post #25 · Nutrition & Training › Resistance training · 15 Nov 2024 · 21 likes Intensity: using weights that allow 6 to 12 reps before fatigue is a reasonable range for preserving muscle. Heavier weights with lower reps can work but require more…
Second pass at: Pharmacy supply in the UK and the questions you will be asked Started this topic · Regional › UK & Ireland · 13 Nov 2024 · 35 likes Second pass at: Pharmacy supply in the UK and the questions you will be asked Writing it up because I had to work it out twice and would rather nobody else did. Asking…
Time to steady state after a dose increase Replied, post #51 · Pharmacology › Pharmacokinetics · 3 Nov 2024 · 18 likes Volume of distribution: the theoretical volume the drug distributes into. For albumin-binding compounds, volume is reduced compared to drugs that do not bind protein.…
Pancreatitis history and the risk calculus — a second dataset Replied, post #8 · Safety › Contraindications · 24 Sep 2024 · 29 likes Adding the measurement that post #5 says would settle it. Medullary thyroid carcinoma (personal or family history) or multiple endocrine neoplasia type 2: absolute…
Identical chromatograms across two different lots Replied, post #25 · Sourcing › Red flags · 14 Sep 2024 · 0 likes Genuine question rather than a rhetorical one: has anyone here actually observed identical chromatograms, as opposed to read about it? The thread is long and I cannot…
Orforglipron as a non-peptide: what changes when the molecule is small Replied, post #4 · Compounds › Oral incretins · 25 Aug 2024 · 1 like Filing a mild objection to the consensus on orforglipron. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.
Progressive overload when the scale is falling — one year on Replied, post #4 · Nutrition & Training › Resistance training · 25 Aug 2024 · 32 likes Strength and hypertrophy respond to different things, and preserving one during a deficit is a different objective from building the other.
Circumference measurements as a poor man's composition estimate Replied, post #73 · Outcomes › Body composition · 17 Aug 2024 · 15 likes Report the method with the number, always. A composition figure without the method is not comparable to anything, including your own previous figure.