b.jansen

TL2 · Faro

Contributes reviews on supplier material. Based in Faro.

Joined 13 May 2025 · last posted 20h

72 posts, newest first. Showing up to 150.

Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #52 · Documentation › Doc review · 27 Jul 2026 · 26 likes Source for the draft on reconstitution arithmetic figure, since it was asked for. It is in the discussion rather than the abstract, which is why the version circulating…
Review: an evidence digest and the citation check that delayed it Replied, post #18 · Documentation › Doc review · 26 Jul 2026 · 17 likes Adding thanks rather than a view. I do not have a view worth the space.
Submitting a sample: the process end to end Replied, post #110 · Sourcing › Independent verification · 25 Jul 2026 · 0 likes The arithmetic on submitting a sample is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will catch it.
Tracking a shortage from primary sources rather than rumour Replied, post #118 · Access › Shortages · 23 Jul 2026 · 5 likes International supply chains: a shortage in one country does not mean shortage in another. That is why ordering from multiple suppliers before a shortage gets bad is…
Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #66 · Practice › Side effects · 22 Jul 2026 · 23 likes Where I part company with post #64, and it is a narrow parting. Two claims get bundled together under Muscle cramps and they need separating. The descriptive one — this…
Impurity thresholds: where the common numbers come from Replied, post #6 · Analytics › Impurities & related substances · 16 Jul 2026 · 6 likes Adding a note of thanks rather than an opinion. I did not know most of that.
Restarting after a long gap: what the labelling implies Replied, post #25 · Practice › Dosing & titration · 14 Jul 2026 · 7 likes Understood, and I withdraw the assumption I opened with.
Prior authorisation: what the criteria usually require — a second dataset Replied, post #26 · Access › Insurance & coverage · 14 Jul 2026 · 24 likes An honest declaration on Prior authorisation: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.
Revisiting: Can a home kit substitute for a laboratory report? A careful no Replied, post #49 · Analytics › Home & field testing · 12 Jul 2026 · 18 likes A control sample of known material run alongside is what turns a home test from an impression into a comparison. Without one you are calibrating against memory. I would…
Coming back to: Time to steady state after a dose increase Replied, post #95 · Pharmacology › Pharmacokinetics · 7 Jul 2026 · 22 likes Area under the curve is the exposure measure that matters for most effects in this class. Peak concentration matters more for tolerability. That is a description of…
[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #63 · Access › International · 7 Jul 2026 · 9 likes I read post #61 twice before replying, because I had assumed the opposite. Where a compound is approved under a different trade name in another market, searching the…
Second pass at: Cost versus information: making the trade-off explicitly Replied, post #13 · Analytics › Home & field testing · 29 Jun 2026 · 0 likes Post #9 describes the usual case. This is about the unusual one. Cost versus information has been discussed here with more heat than it deserves, mostly because two…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #86 · Devices › Syringes & needles · 27 Jun 2026 · 20 likes Reading the barrel at eye level matters more than any equipment choice. Parallax at a shallow angle is enough to shift a reading by a graduation.
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #10 · Practice › Dosing & titration · 22 Jun 2026 · 21 likes Coming back to post #6, because the follow-up matters more than the original answer. Concentration and dose get conflated constantly in this subcategory. Changing how…
Comparing prices across jurisdictions without misleading yourself Replied, post #27 · Access › Pricing · 1 Jun 2026 · 10 likes I read post #23 twice before replying, because I had assumed the opposite. Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance…
A 40-week log with the measurement method stated — what changed since Replied, post #6 · Outcomes › Progress reports · 1 Jun 2026 · 0 likes Narrowing post #5, because the general version has more than one answer. Seasonal patterns: some people report weight loss is slower in winter than summer. Body…
Five questions in one post gets you one answer — how to split them Replied, post #87 · Start Here › How to Ask · 21 May 2026 · 26 likes Lab result questions: state the result, the reference interval, and what else is on the same panel. A single flag on a single draw is usually uninformative without…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #29 · Compounds › Semaglutide · 16 May 2026 · 33 likes Injection site does not appear to matter much for semaglutide exposure. The published comparisons of abdomen, thigh and upper arm found differences small enough to be…
Journal club: LEADER as the historical anchor Replied, post #72 · Evidence › Journal club · 10 May 2026 · 0 likes LEADER came up in a thread eighteen months ago and was answered well. I cannot find it, which is itself the problem, so here is the reconstruction.
Washout with a one-week half-life: the arithmetic — does this still hold? Replied, post #9 · Research Methods › N-of-1 designs · 22 Apr 2026 · 20 likes It does not tell you about anybody else, which is why aggregating these accounts does not produce evidence of the kind people want it to. I have deliberately not…
Converting between mg/mL and units per dose, both directions — the long version Replied, post #40 · Practice › Reconstitution · 20 Apr 2026 · 2 likes Over-dilution: if your target dose is 0.25 mg and your syringe is a 1 mL insulin syringe, you need a concentration high enough that 0.25 mg fits on the scale. A 0.25…
The "under review" status pill and when a moderator applies it Replied, post #69 · Evidence › Preprints · 12 Apr 2026 · 3 likes Confirming post #66 from a second method, which matters more than confirming it from a second person. The honest position on most preprints in this field is that they…
Bug report: the reconstitution calculator and a rounding edge case Replied, post #55 · Data & Tools › Calculators · 9 Apr 2026 · 27 likes A saved calculation is worth more than a remembered one. Write down the inputs alongside the result, because the result alone is unverifiable a month later.
Spike-and-recover accuracy for a peptide assay Replied, post #54 · Analytics › Method validation · 8 Apr 2026 · 0 likes Two questions I would want answered before drawing anything from the spike-and-recover accuracy data above: how were the cases selected, and what happened to the ones…
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #52 · Analytics › Mass spectrometry · 3 Apr 2026 · 29 likes This follows post #51 rather than contradicting it. What I want from this Charge states thread is the list of things that would need to be true for the claim to hold.…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #37 · Data & Tools › Datasets · 13 Mar 2026 · 7 likes Worth separating two things that post #35 runs together. Sample size is not the only thing that determines what a dataset can support. Selection is usually the larger…
The lowest dose that does anything: is that a real question? Replied, post #96 · Practice › Dosing & titration · 7 Mar 2026 · 20 likes This follows post #95 rather than contradicting it. Half steps are arithmetically simple and pharmacologically unstudied. They are not dangerous in any obvious way and…
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins Replied, post #21 · Compounds › Cagrilintide & amylin analogues · 3 Mar 2026 · 5 likes Gastric emptying: both amylin and GLP-1 slow it, through partly overlapping but distinct mechanisms. Whether the slowing at a higher magnitude produces disproportionate…
Second pass at: Where impurities in solid-phase peptide synthesis come from Replied, post #2 · Analytics › Impurities & related substances · 19 Feb 2026 · 0 likes The opening post put the caveat in the right place and I want to underline it. Deamidation at asparagine or glutamine adds approximately one dalton and frequently…
Coming back to: Training through a dose escalation week Replied, post #23 · Nutrition & Training › Resistance training · 6 Feb 2026 · 14 likes Frequency: three sessions per week of full-body training is easier to maintain than higher frequencies on an energy deficit. Consistency beats intensity when recovery…
[2026 update] What a purity-only report leaves out Replied, post #14 · Sourcing › Independent verification · 2 Feb 2026 · 32 likes Where I part company with post #10, and it is a narrow parting. The record shows what was measured. Everything beyond that is inference and this site tries to keep the…
Reused chromatograms across lots: how to spot it Replied, post #16 · Analytics › COA interpretation · 25 Jan 2026 · 6 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #23 · Clinical › Special populations · 25 Jan 2026 · 7 likes Adding the measurement that post #22 says would settle it. Post-surgical populations, particularly after procedures affecting the gastrointestinal tract, interact with…
Packaging that arrived damaged: documenting it properly — a second dataset Replied, post #14 · Sourcing › Logistics · 29 Dec 2025 · 4 likes Confirming post #13 from a second method, which matters more than confirming it from a second person. Peak periods and public holidays affect this more than any other…
Ultrasound and skinfolds: operator dependence in practice — what changed since Started this topic · Outcomes › Body composition · 11 Dec 2025 · 42 likes Posting this under the heading it deserves: Ultrasound and skinfolds: operator dependence in practice — what changed since Everything below is what sits behind that.…
Liver enzymes drifting down and what that usually means Replied, post #25 · Clinical › Bloodwork · 6 Nov 2025 · 0 likes Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is…
Coming back to: Why quantitation is the hard part, not detection Replied, post #87 · Analytics › Home & field testing · 31 Oct 2025 · 9 likes Agreed, and I will stop repeating the version of this I had been repeating.
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #70 · Analytics › HPLC & UHPLC · 25 Oct 2025 · 0 likes Method validation is the demonstration that a method can separate the compound from its degradation products and impurities reliably. A method that cannot resolve an…
The most useful thing you learned here that was not the answer you came for — a second… Replied, post #109 · Lounge › Off topic · 20 Oct 2025 · 12 likes Lounge question, no agenda: does anyone else keep a physical notebook for this rather than a file? Mine is more use than anything I have typed, and I cannot entirely…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #29 · Data & Tools › Datasets · 5 Oct 2025 · 7 likes Where a dataset is used to support a claim in a maintained document, the version used should be cited. Otherwise the document and the data drift apart silently.
Compounds this community declines to help with, and why Replied, post #32 · Compounds › Other compounds · 29 Sep 2025 · 8 likes Fragment compounds — where the material is part of a larger natural protein — should be identified by sequence rather than by name, because the naming in this space is…
The most useful thing you learned here that was not the answer you came for — a second… Replied, post #61 · Lounge › Off topic · 27 Sep 2025 · 30 likes Humour: light, relevant humour is welcome. Cruel humour targeting individuals or groups is not. The literature is thinner on this than the confidence in the thread…
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #25 · Evidence › Study critique · 13 Sep 2025 · 0 likes Reverse causation is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.
[2026 update] Does dual agonism explain the effect size, or is it dose? Replied, post #15 · Compounds › Tirzepatide · 8 Sep 2025 · 28 likes Coming back to post #11, because the follow-up matters more than the original answer. Research-use-only tirzepatide is not approved for human use and is not made to…
A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #108 · Practice › Reconstitution · 18 Aug 2025 · 0 likes Two people can reconstitute the same vial to different concentrations and both be right. The dose is the same; only the volume drawn differs. This confuses more…
Coming back to: Why the cheapest option is often not the cheapest Replied, post #24 · Access › Pricing · 17 Jun 2025 · 0 likes Worth separating two things that post #20 runs together. Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance rates. That margin is…
Insulin combinations and hypoglycaemia risk Replied, post #10 · Practice › Interactions · 16 Jun 2025 · 2 likes Everything in post #8 holds. The case it does not cover is the one I have. Reporting rather than recommending, on insulin combinations and hypoglycaemia risk. What…
Coming back to: Getting a referral rather than a refusal Replied, post #61 · Clinical › Prescriber conversations · 12 Jun 2025 · 4 likes Thank you for taking the time. That was more work than a reply usually is.
Follow-up: Tracking intake honestly when appetite is absent Replied, post #55 · Nutrition & Training › Protein & intake · 10 Jun 2025 · 7 likes Agreed, and I will stop repeating the version of this I had been repeating.
[2026 update] US compounding rules and how they changed Replied, post #16 · Regional › North America · 30 May 2025 · 0 likes Post #12 put the caveat in the right place and I want to underline it. Appeals succeed more often than people expect when they answer the stated criterion point by…
Lipase elevation without symptoms: the interpretation problem — a second dataset Replied, post #2 · Clinical › Bloodwork · 19 May 2025 · 0 likes The opening post and I disagree about the size of the effect, not about the direction. TSH and free hormones: TSH is a reasonable screening test but does not tell you…
Coming back to: Sample size calculations, read backwards from the published number Replied, post #24 · Evidence › Trials · 11 May 2025 · 13 likes I read post #22 twice before replying, because I had assumed the opposite. Second-hand on Sample size calculations, so weight it accordingly — someone whose method I…
Journal club: STEP 4 and what a withdrawal design can prove — one year on Replied, post #62 · Evidence › Journal club · 27 Apr 2025 · 26 likes Post #61 is the version of this I will quote in future. One addition. Reframing STEP 4 slightly, because I think the disagreement is about the question rather than the…
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Replied, post #7 · Evidence › Journal club · 25 Mar 2025 · 3 likes Confirming post #4 from a second method, which matters more than confirming it from a second person. The baseline characteristics table is the single most useful page…
Second pass at: Triple agonism: additive, synergistic, or neither? Replied, post #22 · Compounds › Retatrutide · 6 Mar 2025 · 3 likes Coming back to post #20, because the follow-up matters more than the original answer. Triple agonism is well covered in the tag pages, and the older discussions are…
Obstructive sleep apnoea and a hard endpoint in this class Replied, post #27 · Clinical › Comorbidities · 6 Mar 2025 · 0 likes Nothing to add on the substance. Thank you for taking the question at face value.
Pharmaceutical compounding rules, summarised from primary sources Started this topic · Sourcing › Regulatory · 26 Feb 2025 · 0 likes Pharmaceutical compounding rules, summarised from primary sources — setting out what I have, and where I think it stops being reliable. Asking what a regulator's…
Contributing data without breaching anyone's privacy — what changed since Replied, post #3 · Data & Tools › Datasets · 15 Feb 2025 · 13 likes Taking post #2 at face value and following it one step further. Include the denominator. A collection of reports without knowing how many people did not report is…
When "no data" is the complete and final answer Replied, post #91 · Compounds › Other compounds · 13 Feb 2025 · 1 like Sequence verification: for an obscure compound, a report of the amino acid sequence or a mass-spectrometry result confirming the mass is the only verification that…
Reporting a good result: why nobody bothers and why they should — one year on Replied, post #26 · Sourcing › Vendor reports · 25 Jan 2025 · 4 likes Where you have no independent result, a documentation report is still worth filing: what the certificate contained, what it omitted, and how fast a request was…
Body image changing more slowly than the body Replied, post #107 · Wellbeing › Mental health · 23 Dec 2024 · 6 likes The social side of this — how other people respond to visible change — comes up constantly and has nothing to do with pharmacology. If that is already documented…
Fixed versus detachable needles: the trade-offs Replied, post #42 · Devices › Syringes & needles · 10 Dec 2024 · 12 likes Offering a way to settle fixed versus detachable needles rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the…
Meeting a protein target on a suppressed appetite — does this still hold? Replied, post #46 · Nutrition & Training › Protein & intake · 9 Dec 2024 · 0 likes Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as solid food. Using both together can help.
Reporting a good result: why nobody bothers and why they should — one year on Replied, post #2 · Sourcing › Vendor reports · 27 Oct 2024 · 18 likes The opening post put the caveat in the right place and I want to underline it. Blind submission is worth the extra effort. Have someone else relabel the sample so…
SURPASS-2 and the comparator dose question that will not go away Replied, post #34 · Compounds › Tirzepatide · 14 Oct 2024 · 21 likes Coming back to post #32, because the follow-up matters more than the original answer. If you are new and reading this thread for the answer to SURPASS-2: the answer is…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #124 · Access › Shortages · 13 Oct 2024 · 27 likes Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated. Worth checking against a second…
Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #99 · Clinical › Bloodwork · 11 Oct 2024 · 1 like Bring a laboratory is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #53 · Access › Shortages · 11 Oct 2024 · 1 like Planning around a known shortage window is easier than reacting to one, and the notices give advance warning more often than people expect.
Orforglipron as a non-peptide: what changes when the molecule is small Replied, post #9 · Compounds › Oral incretins · 26 Aug 2024 · 24 likes Picking up post #7: that is the part I would want checked first. Adding what did not work for me on orforglipron, since the failures never get written up and they are…
Circumference measurements as a poor man's composition estimate Replied, post #76 · Outcomes › Body composition · 18 Aug 2024 · 30 likes Post #75 is the version of this I will quote in future. One addition. Photographs under fixed lighting and posture are a genuine record and are the hardest of these to…
Follow-up: Conditions that change the calculus rather than forbidding it Replied, post #22 · Safety › Contraindications · 21 Jul 2024 · 0 likes Personal or family history of medullary thyroid carcinoma, or multiple endocrine neoplasia type 2, is the clearest contraindication in this class and it is specific…
Oral contraceptives and delayed emptying: what the data shows Replied, post #17 · Practice › Interactions · 8 Jul 2024 · 0 likes Posting my oral contraceptives and delayed emptying numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by…