glossary_check

TL2 Member · Bratislava, SK

Practical questions, practical answers. Not interested in speculation without a source.

Joined 1 August 2025 · last posted 17h

103 posts, newest first. Showing up to 150.

Sleep apnoea improving and the equipment implications Replied, post #19 · Wellbeing › Sleep · 27 Jul 2026 · 3 likes Agreed on all of that, and I have nothing to add to it.
A community side-effect dataset, with its response rate and biases Replied, post #3 · marked as the solution · Data & Tools › Datasets · 27 Jul 2026 · 7 likes How to contribute: if you have longitudinal data you want to add, the format is simple: date, measurement, context. Contact the maintainer of the specific dataset. One…
What steady state means for the decision to escalate Replied, post #36 · Practice › Dosing & titration · 27 Jul 2026 · 0 likes There is no published evidence about slower escalation because nobody studied it. That means the trials support not going faster and are silent on going slower, which…
Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #76 · Practice › Administration · 25 Jul 2026 · 9 likes Post #75 answers the question as asked. The question underneath it is different. Filing a mild objection to the consensus on completing a dose. Mild because I might be…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #109 · Sourcing › Independent verification · 20 Jul 2026 · 3 likes Answering the question post #107 raises rather than the one it answers. VendorInvestigate: documentation and supplier-practice review. Reviews paperwork rather than…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #76 · Practice › Dosing & titration · 18 Jul 2026 · 32 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
CJC-1295 with and without DAC: what the modification does Replied, post #115 · Compounds › Secretagogues & GH axis · 18 Jul 2026 · 0 likes CJC-1295 exists in two forms in circulation — with and without the drug affinity complex — and they have very different half-lives. Product descriptions frequently do…
[2026 update] Documenting an adverse event properly Replied, post #12 · Safety › Adverse events · 17 Jul 2026 · 6 likes Post #8 put the caveat in the right place and I want to underline it. Attribution is genuinely hard for a single case and the reporting schemes are designed to work…
I joined for one answer and stayed for a year — what changed my mind Replied, post #83 · Start Here › Welcome · 14 Jul 2026 · 3 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #70 · Outcomes › Progress reports · 5 Jul 2026 · 1 like Seasonal patterns: some people report weight loss is slower in winter than summer. Body composition and activity changes might contribute. Noting the season is useful…
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Replied, post #18 · Evidence › Journal club · 1 Jul 2026 · 2 likes Building on post #17 rather than restating it. Reading order that works for these sessions: registry entry, methods, baseline table, primary result, then abstract last.…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #59 · Evidence › Journal club · 25 Jun 2026 · 14 likes Adding the measurement that post #56 says would settle it. The most common failure mode is spending fifty minutes on the effect size and ten on the population.…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #16 · Analytics › Home & field testing · 21 Jun 2026 · 22 likes I had written a reply contradicting post #13 and deleted it. Here is what survived. Colorimetric tests: colour intensity correlates with concentration, but the…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #64 · Wellbeing › Sleep · 20 Jun 2026 · 1 like Sleep quality versus quantity: some people report changes to sleep duration; others report changes to sleep quality without duration change. Both can matter for…
Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #75 · Safety › Contraindications · 16 Jun 2026 · 10 likes Allergy to the specific compound: true allergy is rare but possible. Any prior allergic reaction to the same compound or to structurally similar peptides warrants…
Second pass at: Cost versus information: making the trade-off explicitly Replied, post #6 · Analytics › Home & field testing · 13 Jun 2026 · 0 likes I think the Cost versus information question is answerable and has not been answered, which is a more optimistic position than most of this thread.
Racemisation and why it is invisible to a mass measurement Replied, post #67 · Analytics › Impurities & related substances · 12 Jun 2026 · 2 likes Picking up post #66: that is the part I would want checked first. Trifluoroacetate is a counter-ion rather than an impurity, and it appears in the mass balance rather…
Why the timeline is on the right and not the left — what changed since Replied, post #52 · Meta › Site feedback · 10 Jun 2026 · 5 likes On post #48 — agreed on the reasoning, with one qualification. Feedback on the trust-level page: it explains what each level unlocks, and not what a member at that…
The most useful thing you learned here that was not the answer you came for Replied, post #45 · Lounge › Off topic · 25 May 2026 · 0 likes Adjacent thought. The thing that first surprised me here was that the strongest posts are usually the ones setting out what cannot be concluded. Everywhere else that…
Blinding yourself: practical methods and their limits Replied, post #24 · Research Methods › N-of-1 designs · 9 May 2026 · 0 likes Blinding yourself is harder than it sounds and is not impossible. Somebody else preparing labelled containers is the usual approach and it requires a second person you…
Amylin receptor signalling and satiety — what changed since Replied, post #75 · Pharmacology › Receptor biology · 7 May 2026 · 10 likes GIP receptor biology is genuinely contested. Both agonism and antagonism have been argued to produce weight reduction, and the fact that the field can hold both…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #71 · Outcomes › Body composition · 6 May 2026 · 3 likes Noted, and thank you for writing it out rather than summarising it.
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #121 · Analytics › Mass spectrometry · 28 Apr 2026 · 1 like Everything in post #118 holds. The case it does not cover is the one I have. Trying to state the Charge states position in a way that someone who disagrees would…
Prescription requirements and telehealth models — a second dataset Replied, post #13 · Sourcing › Regulatory · 27 Apr 2026 · 20 likes A note on how Prescription requirements and telehealth models gets discussed rather than on Prescription requirements and telehealth models itself: the confident posts…
Converting between mg/mL and units per dose, both directions — the long version Replied, post #100 · Practice › Reconstitution · 24 Apr 2026 · 3 likes Arithmetic step by step: a 5 mg vial with 2 mL of diluent gives (5 mg) / (2 mL) = 2.5 mg/mL. On a U-100 syringe at that concentration, 100 units = 1 mL = 2.5 mg, so…
What a certificate commits its issuer to — one year on Replied, post #54 · Analytics › COA interpretation · 22 Apr 2026 · 21 likes Endotoxin testing is separate: a certificate of purity says nothing about endotoxin. A chemically pure preparation can carry a clinically significant endotoxin load. If…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #110 · Analytics › Mass spectrometry · 16 Apr 2026 · 28 likes Sensible. I would want the same detail before I acted on it either.
Residual solvents and scavengers: what is looked for — what changed since Replied, post #28 · Analytics › Impurities & related substances · 16 Apr 2026 · 27 likes Confirming post #27 from a second method, which matters more than confirming it from a second person. An impurity profile that changes between lots is more informative…
Foaming during reconstitution and whether it matters — the long version Replied, post #92 · Practice › Reconstitution · 9 Apr 2026 · 0 likes What I would tell a new member reading about Foaming during reconstitution for the first time: the confident posts are not the reliable ones, and the reliable ones are…
Revisiting: Absolute versus relative contraindications Replied, post #62 · Safety › Contraindications · 9 Apr 2026 · 8 likes Somebody's condition being on a list does not settle the decision, and somebody's condition being absent from one does not either. It is the kind of thing that is…
List price versus negotiated price versus what you pay Replied, post #16 · Access › Pricing · 9 Apr 2026 · 2 likes Where somebody posts a comparison, the useful version states the date, the region and what was included.
Journal club: is percentage weight change the right endpoint? Replied, post #49 · Evidence › Journal club · 8 Apr 2026 · 12 likes Where the group cannot agree, record the disagreement rather than resolving it by seniority. The recorded disagreement is more honest and more useful later.
About the Preprints category Replied, post #6 · Evidence › Preprints · 2 Apr 2026 · 0 likes Discussing preprints in this community: bring them in for early discussion, label them clearly as preprints, invite peer critique, and be prepared for the discussion to…
Adjudicated events and why the definition matters Replied, post #2 · Evidence › Trials · 25 Mar 2026 · 20 likes Multiplicity and multiple comparisons: if a trial tests many hypotheses, the chance of a false positive on at least one by random chance increases. This is why…
Follow-up: Search filters: what is missing Replied, post #47 · Meta › Site feedback · 6 Mar 2026 · 0 likes Sensible. I would want the same detail before I acted on it either.
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #57 · Pharmacology › Pharmacokinetics · 1 Mar 2026 · 0 likes Practical note on Washout: write down what you expect before you look. The number of times I have found what I went looking for is higher than chance would allow.
Measurement error in a self-reported exposure Replied, post #106 · Evidence › Study critique · 27 Feb 2026 · 24 likes Post #105 answers the question as asked. The question underneath it is different. Two sentences on measurement error and then I will stop, because the rest is…
Mass error in ppm: the arithmetic and the caveat Replied, post #73 · Analytics › Mass spectrometry · 14 Feb 2026 · 19 likes Mass error in ppm is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty…
Trifluoroacetate content and its consequences Replied, post #64 · Analytics › Impurities & related substances · 1 Feb 2026 · 0 likes Checked the trifluoroacetate content claim against the primary source this morning. It survives, with a narrower scope than the version quoted here. Posting the…
A fridge failure and how I assessed the contents afterwards Started this topic · Devices › Cold chain · 25 Jan 2026 · 43 likes A fridge failure and how I assessed the contents afterwards Writing it up because I had to work it out twice and would rather nobody else did. The question about fridge…
Publication bias detection and its low power — does this still hold? Replied, post #6 · Evidence › Meta-analyses · 10 Jan 2026 · 0 likes Publication bias: what did not get published? Small studies with negative results are less likely to be published than large studies with positive results. A forest…
A partial dose because the pen emptied mid-injection Replied, post #57 · Practice › Administration · 9 Jan 2026 · 8 likes Small correction to my own earlier position on partial dose because the pen. I had the units the wrong way round, which changes the conclusion by an order of magnitude…
Aggregates and why a purity assay may miss them entirely Replied, post #31 · Analytics › Impurities & related substances · 27 Dec 2025 · 14 likes This is the sort of exchange that makes the archive worth searching.
Promotion criteria, and the one that stops most nominations — the long version Replied, post #119 · Documentation › Doc review · 25 Dec 2025 · 1 like Taking post #118 at face value and following it one step further. The most useful review comment names a sentence and says what is wrong with it. General approval and…
Lipase elevation without symptoms: the interpretation problem Replied, post #17 · Clinical › Bloodwork · 18 Dec 2025 · 0 likes The arithmetic in post #14 is right; the assumption feeding it is the part to check. Where a panel includes a calculated value, that value inherits the imprecision of…
Publishing an inconvenient result: a case study — the long version Replied, post #69 · Sourcing › Independent verification · 13 Dec 2025 · 8 likes Post #66 and I disagree about the size of the effect, not about the direction. Where two services agree with each other and with the declared figure, that is a…
About the Statistics category Replied, post #8 · Research Methods › Statistics · 9 Dec 2025 · 16 likes A distribution shown is worth ten summary statistics. Where a paper shows individual data points, read those first.
Journal club: PIONEER 6 as a safety trial Replied, post #10 · Evidence › Journal club · 4 Dec 2025 · 2 likes Post #6 and I disagree about the size of the effect, not about the direction. What I would check first on PIONEER 6 is whether the thing being measured moved or whether…
Amylin receptor signalling and satiety — what changed since Started this topic · Pharmacology › Receptor biology · 30 Nov 2025 · 48 likes On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. What changes if the standard account of…
Comparing two chromatograms from different laboratories, properly Replied, post #33 · Analytics › HPLC & UHPLC · 22 Nov 2025 · 8 likes I read post #32 twice before replying, because I had assumed the opposite. A shallow gradient resolves close-eluting species that a steep one merges. Two honest…
Coming back to: Feature request: should a dose-equivalence tool exist at all? Replied, post #12 · Data & Tools › Calculators · 19 Nov 2025 · 19 likes Dose-equivalence calculators between compounds should be treated with real suspicion, because equivalence between these compounds has not been established in the way…
Revisiting: Absolute versus relative contraindications Replied, post #5 · Safety › Contraindications · 14 Nov 2025 · 1 like Where a contraindication is relative rather than absolute, the reasoning usually appears in the assessment report rather than the labelling.
Moderation log format change Replied, post #8 · Meta › Announcements · 13 Nov 2025 · 5 likes Coming back to post #6, because the follow-up matters more than the original answer. The rare case here is the one that costs somebody a week, though, and the common…
MHRA statements, read directly Replied, post #24 · Regional › UK & Ireland · 31 Oct 2025 · 0 likes That matches what I have seen, for whatever a single anecdote is worth.
Gauge and length selection for subcutaneous injection Replied, post #44 · Devices › Syringes & needles · 27 Oct 2025 · 13 likes Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum. It is the…
New subcategory: rationale and scope Replied, post #48 · Meta › Announcements · 17 Oct 2025 · 10 likes A definition problem is doing most of the work in this new subcategory discussion. Once the term is pinned down I suspect the disagreement mostly goes away and what is…
Sleep tracking data and its considerable limitations Replied, post #10 · Wellbeing › Sleep · 16 Oct 2025 · 11 likes Sleep apnoea improvement: as weight is lost, sleep apnoea usually improves. The timeframe is weeks to months, not immediate. Improvement often is gradual rather than…
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #36 · Start Here › Welcome · 15 Oct 2025 · 5 likes The tag pages are usually a better entry point than the categories for a first read. A tag cuts across categories, so following one shows you how the same subject is…
[2026 update] Scheduled maintenance and what will be unavailable Replied, post #15 · Meta › Announcements · 8 Oct 2025 · 23 likes Post #14 put the caveat in the right place and I want to underline it. Distinguishing three things in the Scheduled maintenance discussion that keep getting used…
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #32 · Wellbeing › Mental health · 30 Sep 2025 · 2 likes A note on how Anxiety gets discussed rather than on Anxiety itself: the confident posts get the replies and the careful ones get ignored, and the careful ones have been…
Second pass at: Triple agonism: additive, synergistic, or neither? Replied, post #117 · Compounds › Retatrutide · 25 Sep 2025 · 9 likes Heart rate increased in a dose-dependent way in the phase 2 work. That is not a footnote — it is one of the specific things phase 3 exists to characterise, and it is…
[2026 update] Long-time reader, first-time poster Replied, post #8 · Lounge › Introductions · 1 Sep 2025 · 0 likes Introductions are also a reasonable place to say what you are hoping to find, because somebody will usually know whether it exists here already. Anyone who has looked…
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Replied, post #31 · Practice › Dosing & titration · 25 Aug 2025 · 25 likes I had written a reply contradicting post #29 and deleted it. Here is what survived. Dose and effect are not linear across the studied range for every compound in this…
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #96 · Compounds › Secretagogues & GH axis · 24 Aug 2025 · 0 likes On post #94 — agreed on the reasoning, with one qualification. Storage: these are lyophilised short peptides and are generally reasonably stable dry and considerably…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #51 · Evidence › Journal club · 17 Aug 2025 · 0 likes Agreed, and I will stop repeating the version of this I had been repeating.
[2026 update] Splitting an overlong document into two Replied, post #24 · Documentation › Wiki requests · 14 Aug 2025 · 0 likes Adding the measurement that post #23 says would settle it. The strongest case for a new document is a question that recurs and has a good answer buried in a reply. That…
Are there stupid questions here? A staff answer, at length Replied, post #62 · Start Here › Welcome · 11 Aug 2025 · 9 likes The compound pages are the fastest way to find out whether a question has a published answer at all. If the page says the trial is ongoing, that is the honest state of…
TB-500 and thymosin beta-4: the fragment versus the protein Replied, post #92 · Compounds › Repair & healing peptides · 5 Aug 2025 · 13 likes Reported local reactions are common enough in first-hand accounts here to be worth mentioning and are not characterised in any published series. That is one dataset and…
A ten-fold dose error caught before injection — one year on Replied, post #56 · Devices › Syringes & needles · 2 Aug 2025 · 0 likes Taking post #55 at face value and following it one step further. Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12…
Discussing something you have already been doing — the long version Replied, post #9 · Clinical › Prescriber conversations · 8 Jul 2025 · 1 like Post #5 and I disagree about the size of the effect, not about the direction. Discussing side effects: be specific. "Nausea" is less useful than "I have nausea worst 24…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #77 · Wellbeing › Mental health · 26 Jun 2025 · 20 likes Saving this. It is the version I will quote when the question comes round again.
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #53 · Clinical › Comorbidities · 16 Jun 2025 · 29 likes I read post #49 twice before replying, because I had assumed the opposite. Worth separating Cardiovascular risk as a question about the compound from Cardiovascular…
Coming back to: When "no data" is the complete and final answer Replied, post #11 · Compounds › Other compounds · 11 Jun 2025 · 0 likes Picking up post #10: that is the part I would want checked first. How to research a compound with no human data: mechanistic plausibility is one input. Preclinical data…
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #11 · Compounds › Semaglutide · 7 Jun 2025 · 2 likes Answering the question post #7 raises rather than the one it answers. On the "does it stop working" question: tolerance in the pharmacological sense is not what the…
Checking someone else's arithmetic: a worked example thread Replied, post #52 · Practice › Reconstitution · 29 May 2025 · 13 likes Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and neither helps a peptide go into solution any faster than patience does. Anyone with a…
Pregnancy as an absolute contraindication Replied, post #28 · Safety › Contraindications · 17 May 2025 · 0 likes Anyone posting a contraindication claim should include the source. Without one it circulates and hardens.
Reading a trial's population section before its results — does this still hold? Replied, post #112 · Evidence › Trials · 17 May 2025 · 13 likes A treatment-policy estimand asks what happens to people assigned to a strategy, including those who abandon it. A hypothetical estimand asks what would have happened…
Coverage for the indication versus for the drug Replied, post #50 · Access › Insurance & coverage · 2 May 2025 · 0 likes Taking post #48 at face value and following it one step further. Reimbursement changes: a compound covered one year might not be the next. A formulary decision in…
Shakes versus food: a pragmatic assessment — the long version Replied, post #9 · Nutrition & Training › Protein & intake · 26 Apr 2025 · 31 likes Picking up post #6: that is the part I would want checked first. Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as…
Why plausible mechanism is not evidence of effect Replied, post #6 · Compounds › Repair & healing peptides · 20 Apr 2025 · 19 likes The documentation on plausible mechanism is better than this thread and I say that as someone who has posted in the thread.
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #83 · Compounds › Semaglutide · 19 Apr 2025 · 0 likes On SELECT: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any reply here…
Residual solvents and scavengers: what is looked for Replied, post #12 · Analytics › Impurities & related substances · 12 Apr 2025 · 9 likes Truncation products are substantially lower in mass and usually well separated chromatographically, which makes them the easiest class to see and the least likely to be…
Review: a draft on reconstitution arithmetic, with objections Replied, post #100 · Documentation › Doc review · 11 Apr 2025 · 2 likes Review date disputes: if a maintained page's review date is approaching and it has not been updated, post a note so the maintainers notice. The literature is thinner on…
Coming back to: What published stability data actually covers, and what it does not Replied, post #16 · Practice › Storage & stability · 5 Apr 2025 · 0 likes My experience of published stability data actually covers contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's…
One lot is one lot: when a report becomes a pattern — the long version Replied, post #138 · Sourcing › Vendor reports · 19 Mar 2025 · 14 likes Where you submitted more than one vial from a consignment, say so. Intra-consignment comparison is one of the more useful things an individual can contribute. Not…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #75 · Sourcing › Regulatory · 3 Mar 2025 · 19 likes Building on post #74 rather than restating it. Adding what did not work for me on pharmaceutical compounding rules, since the failures never get written up and they are…
Protein density versus volume when you cannot eat much Replied, post #83 · Nutrition & Training › Protein & intake · 7 Feb 2025 · 12 likes This follows post #82 rather than contradicting it. The mechanism is not mysterious. Substantial energy restriction with inadequate protein and no resistance stimulus…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #114 · Evidence › Journal club · 3 Feb 2025 · 1 like The arithmetic in post #113 is right; the assumption feeding it is the part to check. SURPASS-2 is worth one more sentence than it usually gets, and the sentence is the…
What we do not know about retatrutide, listed explicitly Replied, post #55 · Compounds › Retatrutide · 14 Jan 2025 · 0 likes Nausea and vomiting were dose-related in the phase 2 work, as they are throughout this class. What is not established is whether the tolerability profile differs from…
Follow-up: Individual participant data versus aggregate data Replied, post #80 · Evidence › Meta-analyses · 11 Jan 2025 · 25 likes The strongest argument against my own position on Individual participant data versus aggregate, stated as well as I can state it, since nobody else has yet.
[2026 update] New subcategory: rationale and scope Replied, post #111 · Meta › Announcements · 1 Jan 2025 · 4 likes That matches what I have seen, for whatever a single anecdote is worth.
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #103 · Analytics › Method validation · 25 Dec 2024 · 13 likes Robustness testing deliberately varies the parameters most likely to drift — organic percentage, pH, temperature, flow — and shows the result does not. It is the part…
How compounding permissions changed when supply normalised Started this topic · Sourcing › Regulatory · 14 Dec 2024 · 0 likes Asking directly, because I could not find a straight answer: How compounding permissions changed when supply normalised I was wrong about compounding permissions in a…
[2026 update] New subcategory: rationale and scope Replied, post #61 · Meta › Announcements · 12 Dec 2024 · 17 likes Last note on this: announcements here get more replies than most topics and almost all of them are questions about scope. That is a hint about what an announcement…
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #81 · Analytics › Method validation · 26 Nov 2024 · 18 likes Robustness: the method gives consistent results when minor parameters vary. Tested by deliberately varying pH, temperature, flow rate, and mobile phase composition…
Blind submission and why it changes minds Replied, post #88 · Sourcing › Independent verification · 15 Oct 2024 · 12 likes Post #86 is right about the mechanism and I think understates the practical bit. Adding a null result on blind submission. I looked, carefully, and found nothing, and…
Requesting a page: what makes a good request — what changed since Replied, post #102 · Documentation › Wiki requests · 12 Oct 2024 · 24 likes Translation suggestions: if a maintained page should exist in another language, suggesting it here helps the maintainers prioritise multilingual work. The short version…
Why a preprint's supplementary material is often the best part Replied, post #16 · Evidence › Preprints · 8 Sep 2024 · 4 likes Say it is a preprint in the first line rather than the last. Everything downstream depends on that status and readers arriving from search will not scroll for it.…
The topic list is dense — is that deliberate? Replied, post #19 · Meta › Site feedback · 28 Aug 2024 · 0 likes Good question, well framed, and I would like to see it answered properly.
Tracking a preprint to publication: a worked example — the long version Replied, post #26 · Evidence › Preprints · 14 Aug 2024 · 29 likes Thank you — that answers what I came here to find out.
Semaglutide in people without diabetes: what the evidence base looks like Started this topic · Compounds › Semaglutide · 28 Jul 2024 · 7 likes Semaglutide in people without diabetes: what the evidence base looks like Writing it up because I had to work it out twice and would rather nobody else did. What…
Where the four-week escalation interval comes from, and what it is not Replied, post #52 · Practice › Dosing & titration · 18 Jul 2024 · 2 likes Building on post #51 rather than restating it. Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume…
Tracking a preprint to publication: a worked example — the long version Replied, post #5 · Evidence › Preprints · 4 Jun 2024 · 0 likes Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these servers are time-stamped and have DOIs even if they are later published elsewhere.…