Bramley

TL2 Member · Trento, IT

Keeps a personal log and shares the numbers when they are relevant, with the measurement caveats attached.

Joined 12 May 2025 · last posted 10d

97 posts, newest first. Showing up to 150.

What I would want from a home test that does not exist yet — what changed since Replied, post #99 · Analytics › Home & field testing · 18 Jul 2026 · 11 likes Post #95 describes the usual case. This is about the unusual one. Photographs of test results posted here are worth including with the lighting and the timing stated,…
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #36 · Practice › Interactions · 17 Jul 2026 · 7 likes Oral medications with a narrow therapeutic index are the ones where that matters most. The interaction is about rate and timing rather than about the total absorbed, in…
Common supplements people ask about, assessed one at a time Replied, post #50 · Practice › Interactions · 15 Jul 2026 · 10 likes Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric emptying), the delayed stomach emptying affects when and…
Asking a follow-up: new topic or new reply? Replied, post #50 · Start Here › How to Ask · 12 Jul 2026 · 1 like Post #46 describes the usual case. This is about the unusual one. A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the…
Micro-titration: a disputed topic, argued properly Replied, post #103 · Practice › Dosing & titration · 11 Jul 2026 · 0 likes I would put moderate confidence on the mainstream reading of micro-titration and no more. That is not scepticism for its own sake; it is where the sourcing actually…
Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #26 · Clinical › Comorbidities · 11 Jul 2026 · 10 likes Where I part company with post #22, and it is a narrow parting. On Osteoarthritis and mechanical versus metabolic, the part that usually goes wrong is that the question…
Journal club: LEADER as the historical anchor Replied, post #101 · Evidence › Journal club · 8 Jul 2026 · 0 likes I have three months of notes on LEADER and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion…
Follow-up: UK access routes, dated and sourced Replied, post #10 · marked as the solution · Regional › UK & Ireland · 8 Jul 2026 · 8 likes Where the compound is supplied with a device, the device and the compound have separate availability positions and the device is more often the constraint. I am aware…
How shortages have affected compounding permissions Replied, post #21 · Access › Shortages · 7 Jul 2026 · 7 likes Worth separating two things that post #17 runs together. Shortages is a good example of a question where the honest answer is boring and the interesting answers are…
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #25 · Compounds › Retatrutide · 6 Jul 2026 · 29 likes Same experience here, different supplier, so it is at least not unique to one of them.
Revisiting: Liver enzymes drifting down and what that usually means Replied, post #52 · Clinical › Bloodwork · 4 Jul 2026 · 8 likes What I would check first on Liver enzymes drifting is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.
Programming during a large energy deficit Replied, post #31 · Nutrition & Training › Resistance training · 3 Jul 2026 · 0 likes Strength and hypertrophy respond to different things, and preserving one during a deficit is a different objective from building the other.
Revisiting: Body image changing more slowly than the body Replied, post #8 · Wellbeing › Mental health · 1 Jul 2026 · 6 likes Worth separating two things that post #6 runs together. A request rather than an answer: could whoever has the primary source for Body image post it? I have seen the…
Revisiting: The best-written scientific paper you have read Replied, post #64 · Lounge › Off topic · 1 Jul 2026 · 6 likes Science communication: if you come across an interesting science paper or article about peptides or metabolism, sharing it and discussing the idea is on-topic. None of…
Reflectance and photometric devices: precision in practice — a second dataset Replied, post #60 · Analytics › Home & field testing · 28 Jun 2026 · 12 likes Coming back to post #58, because the follow-up matters more than the original answer. The most useful home practice is not a test at all: photograph the vial, the cake,…
Racemisation and why it is invisible to a mass measurement Replied, post #99 · Analytics › Impurities & related substances · 14 Jun 2026 · 22 likes Dimer and higher-order multimers: two or more peptide molecules bonded together. They appear at double the mass and higher. They may or may not separate from the…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #42 · Analytics › HPLC & UHPLC · 13 Jun 2026 · 14 likes Injection volume matters because column overload distorts peak shape, and an overloaded main peak can swallow a small neighbour. A certificate without injection volume…
I joined for one answer and stayed for a year — what changed my mind Replied, post #18 · Start Here › Welcome · 12 Jun 2026 · 0 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #9 · Analytics › HPLC & UHPLC · 6 Jun 2026 · 2 likes Adding the boring version of Carryover, because the interesting version keeps getting posted and the boring one is usually right. Check the ordinary explanations, in…
Follow-up: I have no scientific background — can I still follow the analytics categories? Replied, post #18 · Start Here › Welcome · 3 Jun 2026 · 0 likes Muting is under-used here. A category you mute stops appearing in Latest for you, and you can unmute it in a second. Most long-term members read four or five categories…
Why this subcategory is stricter about sourcing than most Replied, post #37 · Compounds › Secretagogues & GH axis · 1 Jun 2026 · 14 likes Reconstitution volumes in this family are often small enough that dead volume in the syringe is a meaningful fraction of the dose. A fixed-needle insulin syringe is…
Citation sweep results: how many references did not say what was claimed Replied, post #101 · Meta › Wiki maintenance · 24 May 2026 · 6 likes Post #100 and I disagree about the size of the effect, not about the direction. If you are new and reading this thread for the answer to citation sweep results: the…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one… Replied, post #20 · Compounds › Oral incretins · 14 May 2026 · 24 likes Orforglipron is a small molecule rather than a peptide, which changes almost everything about how it is made, stored and analysed. Comparing it to oral semaglutide as…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #44 · Practice › Reconstitution · 13 May 2026 · 5 likes Post #43 is right about the mechanism and I think understates the practical bit. The best check on any reconstitution calculation is to do it twice by two different…
Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Replied, post #16 · Compounds › Oral incretins · 12 May 2026 · 4 likes Oral versus injectable exposure: comparing a 14 mg oral dose with a 0.5 mg injectable dose is comparing apples to a different fruit. The oral bioavailability is low…
[2026 update] Why 99.2% and 97.8% on the same lot can both be correct Started this topic · Analytics › HPLC & UHPLC · 30 Apr 2026 · 13 likes Why 99.2% and 97.8% on the same lot can both be correct — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to…
Does a peptide degrade silently, with no visual change? Replied, post #15 · Practice › Storage & stability · 24 Apr 2026 · 2 likes Visual inspection: if a solution is visibly cloudy, discoloured, or contains particles, those are red flags. Faint opalescence or minor colour shift may be normal but…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #48 · Sourcing › Logistics · 21 Apr 2026 · 25 likes The most useful reply I ever got about Regional warehouse stock versus direct was a request to state my units. It sounds like pedantry and it has saved me twice.
Subgroup analyses: pre-specified versus discovered — a second dataset Replied, post #38 · Evidence › Trials · 9 Apr 2026 · 14 likes I will take the caveat as seriously as the claim, which is the point of putting it there.
Choosing which test to pay for, given a fixed budget Replied, post #56 · Sourcing › Independent verification · 6 Apr 2026 · 19 likes A record with four results over sixteen months is a thin record rather than a bad one, and the honest description says which. If that reads as pedantic, it is, and it…
Grapefruit: why this class is not the class that cares Replied, post #68 · Practice › Interactions · 22 Mar 2026 · 27 likes Delayed gastric emptying is the mechanism behind most of the plausible interactions in this class: anything whose absorption depends on how quickly the stomach empties…
Search filters: what is missing Replied, post #37 · Meta › Site feedback · 18 Mar 2026 · 25 likes Marking my place. If it changes for me I will come back and say so.
Revisiting: Maintainer handover: how it works Replied, post #38 · Meta › Wiki maintenance · 8 Mar 2026 · 8 likes I had written a reply contradicting post #35 and deleted it. Here is what survived. The failure mode on Maintainer handover is boring rather than dramatic. It is almost…
Pre-registering a personal experiment, seriously — a second dataset Replied, post #38 · Research Methods › N-of-1 designs · 2 Mar 2026 · 0 likes Narrowing post #35, because the general version has more than one answer. Pre-registering a personal experiment has been discussed here with more heat than it deserves,…
Grapefruit: why this class is not the class that cares Replied, post #6 · Practice › Interactions · 2 Mar 2026 · 16 likes Picking up post #5: that is the part I would want checked first. The useful distinction on grapefruit is between what was measured and what was inferred from it. Both…
Bioimpedance and hydration: why the number moves Replied, post #13 · Outcomes › Body composition · 2 Mar 2026 · 9 likes The most useful protocol is the one you will actually repeat identically. An imperfect measurement repeated consistently beats a better one repeated carelessly. Take it…
Forced degradation studies: designing one that is informative Replied, post #13 · Analytics › Method validation · 1 Mar 2026 · 10 likes I read post #9 twice before replying, because I had assumed the opposite. Where a pharmacopoeial monograph exists, a method that follows it inherits a great deal of…
Moderation log format change Replied, post #30 · Meta › Announcements · 19 Feb 2026 · 0 likes I read post #28 twice before replying, because I had assumed the opposite. The edit is clearer. For anyone arriving now, read the edited version — the confusion in the…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #24 · Outcomes › Body composition · 7 Feb 2026 · 2 likes Where I part company with post #22, and it is a narrow parting. Comparison to published data: the trials reported mean fat and lean mass changes. Individual results…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #53 · Documentation › Wiki requests · 24 Jan 2026 · 14 likes Suggesting content for a page: if you know a maintained page is missing something important, post a suggestion with specific content you think should be added.
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #53 · Start Here › How to Ask · 16 Jan 2026 · 33 likes Do not apologise in the first line. It costs you the space where the question should be, and nobody here thinks a question is an imposition.
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Replied, post #21 · Data & Tools › Calculators · 12 Jan 2026 · 0 likes Narrowing post #20, because the general version has more than one answer. A saved calculation is worth more than a remembered one. Write down the inputs alongside the…
Reading an interaction checker output critically Replied, post #90 · Practice › Interactions · 12 Jan 2026 · 8 likes Absence of an interaction study is not evidence of no interaction. A great many combinations discussed here have simply never been studied, and saying so is more useful…
A partial dose because the pen emptied mid-injection Replied, post #103 · Practice › Administration · 10 Jan 2026 · 0 likes Confirming post #100 from a second method, which matters more than confirming it from a second person. A genuinely late dose: the labelling generally says that if the…
Second pass at: Metformin co-administration and additive GI effects Replied, post #29 · Practice › Interactions · 6 Jan 2026 · 0 likes Post #28 is right about the mechanism and I think understates the practical bit. Where I have landed on Metformin co-administration, having got it wrong once in public:…
Amylin receptor signalling and satiety — what changed since Replied, post #4 · Pharmacology › Receptor biology · 13 Dec 2025 · 8 likes On the opening post — agreed on the reasoning, with one qualification. Long-term receptor changes: very little is known about what happens to receptor expression,…
Prescription requirements and telehealth models Replied, post #61 · Sourcing › Regulatory · 11 Dec 2025 · 0 likes If you can confirm or contradict a position for your own region, please date the answer. An undated regional claim is the least useful thing in this category. Posted…
"Greater than or equal to 99%" as a specification rather than a result Replied, post #77 · Analytics › COA interpretation · 25 Nov 2025 · 1 like The distinction between release testing and characterisation is one industrial documents make and retail ones usually do not. It is the difference between "we tested…
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #63 · Compounds › Oral incretins · 19 Nov 2025 · 17 likes Coming back to post #59, because the follow-up matters more than the original answer. Why administration conditions matter for oral semaglutide and not for injectables:…
A parcel that arrived warm: a decision process, not a verdict Replied, post #117 · Practice › Storage & stability · 2 Nov 2025 · 0 likes Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear. That holds for…
Follow-up: Constipation management, with a dietitian's contribution Replied, post #2 · Practice › Side effects · 10 Oct 2025 · 21 likes Thank you for taking the time. That was more work than a reply usually is.
Cagrilintide's dosing interval and the pharmacokinetics behind it Replied, post #6 · Compounds › Cagrilintide & amylin analogues · 30 Sep 2025 · 15 likes Reconstitution at higher concentrations is worth avoiding for aggregation-prone material. The published formulation work generally uses lower concentrations than people…
Escalating every six weeks instead of four: what I observed over eight months — one year… Replied, post #58 · Practice › Dosing & titration · 16 Sep 2025 · 0 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #123 · Evidence › Study critique · 16 Sep 2025 · 3 likes Bookmarking this. I will come back when I have something worth adding.
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #76 · Devices › Cold chain · 13 Sep 2025 · 2 likes Do not judge cold-chain performance from a single delivery in either direction. It is a distribution and one sample from it is one sample. I checked the source rather…
Documentation that appears only after payment Replied, post #20 · Sourcing › Red flags · 8 Sep 2025 · 13 likes An honest declaration on documentation: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.
Guidelines revision: what changed and why — one year on Replied, post #13 · Meta › Announcements · 5 Sep 2025 · 14 likes Worth separating two things that post #11 runs together. Archives: older announcements are archived by date. Checking archives is useful if you want to know what…
Tirzepatide molecular mass and the charge states you would expect on ESI Replied, post #25 · Compounds › Tirzepatide · 28 Aug 2025 · 0 likes Post #21 describes the usual case. This is about the unusual one. Storage and stability: published data on licensed tirzepatide formulations exists and is worth reading…
Asking about a compound your prescriber has not heard of Replied, post #134 · Clinical › Prescriber conversations · 22 Aug 2025 · 0 likes Where you disagree, saying so plainly and asking for the reasoning is better than agreeing and not following the plan.
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #84 · Evidence › Journal club · 22 Aug 2025 · 3 likes Coming back to post #82, because the follow-up matters more than the original answer. The baseline characteristics table is the single most useful page for the…
Hypertension improvement and when medication needs revisiting Replied, post #10 · Clinical › Comorbidities · 15 Aug 2025 · 21 likes Asking about a population rather than about yourself is a legitimate framing and generally gets a better answer, because the general case is answerable. If anyone can…
IGF-1 as a surrogate endpoint and its limitations — the long version Replied, post #18 · Compounds › Secretagogues & GH axis · 5 Aug 2025 · 33 likes The strongest argument against my own position on IGF-1, stated as well as I can state it, since nobody else has yet.
How to research a compound with no human data without deceiving yourself Replied, post #37 · Compounds › Other compounds · 1 Aug 2025 · 6 likes I changed my mind about research a compound after someone here asked me for the source and I could not produce one. That is worth saying out loud because it is the…
Immortal time bias in a claims-database study Replied, post #8 · Evidence › Study critique · 28 Jul 2025 · 0 likes Reporting bias within a paper — a result in a figure that is absent from the abstract — is checkable and is worth checking when the claim matters. That is the version I…
A preprint whose numbers changed substantially at publication Replied, post #4 · Evidence › Preprints · 27 Jul 2025 · 5 likes Reading rather than answering, but this is the post I would point somebody at.
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #88 · Compounds › Semaglutide · 26 Jul 2025 · 3 likes Confirming post #87 from a second method, which matters more than confirming it from a second person. On alcohol: the labelling does not contraindicate it, but it…
Journal club: STEP 8 and the fairness of the comparator dose Replied, post #2 · Evidence › Journal club · 22 Jul 2025 · 0 likes Adding the measurement that the opening post says would settle it. The question underneath STEP 8 is usually "how would I tell?" rather than "what is true?", and that…
Why the timeline is on the right and not the left Replied, post #43 · Meta › Site feedback · 20 Jul 2025 · 17 likes This follows post #40 rather than contradicting it. Timeline is worth one more sentence than it usually gets, and the sentence is the one about how the number was…
Revisiting: Why a compound being unapproved is not the same as being illegal to possess Replied, post #54 · Sourcing › Regulatory · 19 Jul 2025 · 0 likes Preclinical versus clinical: compounds with strong preclinical data can fail in clinical trials. Compounds with no human data are being used on theoretical grounds. The…
Interpreting a composition change that is within the error bars Replied, post #14 · Outcomes › Body composition · 10 Jul 2025 · 0 likes Narrowing post #11, because the general version has more than one answer. Precision versus accuracy: the precision you need depends on what question you are answering.…
Revisiting: Reading a denial letter as a specification for your appeal Replied, post #29 · Access › Insurance & coverage · 29 Jun 2025 · 0 likes Post #27 answers the question as asked. The question underneath it is different. Where I have landed on Reading a denial letter, having got it wrong once in public: the…
Why plausible mechanism is not evidence of effect Replied, post #17 · Compounds › Repair & healing peptides · 23 Jun 2025 · 0 likes The arithmetic on plausible mechanism is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will catch it.
Half-life, steady state, and accumulation worked through Replied, post #81 · Pharmacology › Pharmacokinetics · 7 Jun 2025 · 0 likes Reading back through, this was answered upthread and I missed it. My fault.
Half-life, steady state, and accumulation worked through Replied, post #64 · Pharmacology › Pharmacokinetics · 4 Jun 2025 · 18 likes I read the earlier replies on half-life twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing with what was said rather…
A well-designed study with a badly written abstract Replied, post #83 · Evidence › Study critique · 15 May 2025 · 22 likes I came in to disagree and I am leaving without a disagreement.
TB-500 and thymosin beta-4: the fragment versus the protein Replied, post #12 · Compounds › Repair & healing peptides · 11 May 2025 · 10 likes The pentadecapeptide sequence is short and stable enough to survive conditions that would degrade a larger peptide, which is one of the few things about it that is well…
Validating a calculator against hand arithmetic — what changed since Replied, post #49 · Data & Tools › Calculators · 4 May 2025 · 2 likes Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be…
A supplier that answers analytical questions with restated claims Replied, post #52 · Sourcing › Red flags · 6 Apr 2025 · 0 likes I have three months of notes on supplier and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion…
A certificate with no method stated: what can you conclude? Replied, post #15 · Analytics › COA interpretation · 1 Apr 2025 · 3 likes Post #14 answers the question as asked. The question underneath it is different. The fields that make one usable: lot identifier matching the container, test date,…
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #13 · Compounds › Semaglutide · 16 Feb 2025 · 4 likes The opalescent appearance in semaglutide solutions is occasionally noted and the mechanism is unclear. It does not appear to correlate with product failure in practice.…
Protein density versus volume when you cannot eat much Replied, post #3 · Nutrition & Training › Protein & intake · 21 Jan 2025 · 1 like The mechanism is not mysterious. Substantial energy restriction with inadequate protein and no resistance stimulus loses lean tissue as well as fat. Reporting the…
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated… Replied, post #11 · Compounds › Secretagogues & GH axis · 18 Jan 2025 · 20 likes Taking GHRH analogues versus ghrelin mimetics seriously for a moment rather than deflecting: the honest position is that the community has observations and no…
Research-use-only labelling: what it means and what it does not — the long version Replied, post #57 · Sourcing › Regulatory · 4 Jan 2025 · 2 likes Research-use-only labelling is a good example of a question where the honest answer is boring and the interesting answers are unsupported. I would go with boring.
Oral semaglutide bioavailability and its variability between people — a second dataset Replied, post #124 · Compounds › Oral incretins · 28 Dec 2024 · 5 likes PIONEER 6 is the cardiovascular outcome trial for oral semaglutide and it enrolled a diabetes population at high cardiovascular risk. Quoting it outside that population…
[2026 update] New subcategory: rationale and scope Replied, post #34 · Meta › Announcements · 1 Dec 2024 · 13 likes Practical note on New subcategory: write down what you expect before you look. The number of times I have found what I went looking for is higher than chance would allow.
Meeting a protein target on a suppressed appetite — does this still hold? Replied, post #30 · Nutrition & Training › Protein & intake · 30 Nov 2024 · 7 likes Reading this Meeting a protein target thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not.
Washout with a one-week half-life: the arithmetic Replied, post #8 · Research Methods › N-of-1 designs · 23 Nov 2024 · 0 likes What I would want before treating washout as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing.
Coming back to: Grapefruit: why this class is not the class that cares Replied, post #26 · Practice › Interactions · 13 Nov 2024 · 5 likes I read post #25 twice before replying, because I had assumed the opposite. A pharmacist can answer most questions in this subcategory in a few minutes with access to a…
Follow-up: Dead volume across syringe and needle combinations Replied, post #60 · Devices › Syringes & needles · 4 Nov 2024 · 0 likes Filter needles are for drawing from glass ampoules where particulate is a real risk. For a stoppered vial they add dead volume in exchange for very little.
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #96 · Analytics › COA interpretation · 26 Oct 2024 · 0 likes Reading old certificates: if a certificate is dated years ago, the lot it describes might be old. That is not automatically a problem but it is worth noting. Fresh…
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #57 · Analytics › Method validation · 23 Oct 2024 · 0 likes An independent laboratory's method being different from the supplier's is not a discrepancy. It becomes one only when the results differ by more than both methods'…
SNAC and the mechanism of oral peptide absorption — the long version Replied, post #5 · Compounds › Oral incretins · 11 Oct 2024 · 11 likes PIONEER 6 is the cardiovascular outcome trial for oral semaglutide and it enrolled a diabetes population at high cardiovascular risk. Quoting it outside that population…
Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #63 · Clinical › Bloodwork · 28 Sep 2024 · 4 likes Answering the question post #59 raises rather than the one it answers. What I would want before treating bring a laboratory as settled: the method, the sample, and…
Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #42 · Compounds › Retatrutide · 17 Sep 2024 · 22 likes Glucagon receptor agonism seems paradoxical in a weight-loss compound because glucagon raises blood glucose. The paradox resolves because glucagon agonism also…
Blind submission and why it changes minds Replied, post #58 · Sourcing › Independent verification · 11 Sep 2024 · 13 likes I had written a reply contradicting post #54 and deleted it. Here is what survived. Blind submission is worth one more sentence than it usually gets, and the sentence…
How to ask for a dose change without antagonising anyone Replied, post #12 · Clinical › Prescriber conversations · 6 Aug 2024 · 0 likes Everything in post #10 holds. The case it does not cover is the one I have. Clarifying indication: if a compound is approved for diabetes but you have obesity without…
How this community labels and discusses unrefereed work Replied, post #80 · Evidence › Preprints · 13 Jul 2024 · 6 likes The arithmetic in post #79 is right; the assumption feeding it is the part to check. Unrefereed work is not worthless. A great deal of it survives review substantially…