r.mensah

TL2 · Aarhus

Contributes reviews on supplier material. Based in Aarhus.

Joined 6 February 2025 · last posted 12h · groups: newcomer-guides

96 posts, newest first. Showing up to 150.

Why the cheapest option is often not the cheapest Replied, post #24 · Access › Pricing · 27 Jul 2026 · 29 likes For anyone finding this later: the short answer on cheapest option is that it depends on one thing, and the rest of the thread is people identifying which thing.
Seven-day rolling means and why weekly readings mislead Replied, post #102 · Outcomes › Progress reports · 24 Jul 2026 · 9 likes Measurement noise: day-to-day body mass varies by more than a kilogram on hydration, glycogen, and gut contents alone. A weekly reading is a single noisy sample of a…
What a certificate commits its issuer to Replied, post #76 · Analytics › COA interpretation · 21 Jul 2026 · 0 likes Everything in post #73 holds. The case it does not cover is the one I have. A chromatogram supplied as a small image is legible for peak shape and not for baseline…
Second pass at: Which categories are strict and which are relaxed, honestly Replied, post #86 · Start Here › Welcome · 3 Jul 2026 · 21 likes Likes here mean "this helped", not "I agree". People like posts that argue against them, and that is deliberate. Worth checking against a second source before it gets…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #110 · Sourcing › Logistics · 22 Jun 2026 · 1 like Saving this. It is the version I will quote when the question comes round again.
Forced degradation studies: designing one that is informative Replied, post #81 · Analytics › Method validation · 21 Jun 2026 · 3 likes The most useful single question about a method: what would it fail to detect? Every method has an answer and few documents state it. That is the version I would defend.…
Revisiting: What pooling buys you and what it destroys Replied, post #62 · Evidence › Meta-analyses · 21 Jun 2026 · 1 like Where I part company with post #58, and it is a narrow parting. Offering a way to settle pooling buys rather than another opinion about it. Two measurements, taken the…
Batch numbers that do not match the vial label Replied, post #28 · Sourcing › Red flags · 12 Jun 2026 · 27 likes Narrowing post #27, because the general version has more than one answer. Adding what did not work for me on batch numbers, since the failures never get written up and…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #87 · Evidence › Journal club · 10 Jun 2026 · 21 likes Where I part company with post #83, and it is a narrow parting. Practical experience of orforglipron phase 2, offered as one case with the conditions stated, not as a…
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #64 · Practice › Storage & stability · 6 Jun 2026 · 7 likes Filing a mild objection to the consensus on reconstituted. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.
A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #58 · Practice › Interactions · 5 Jun 2026 · 28 likes Post #56 put the caveat in the right place and I want to underline it. Offering a way to settle widely repeated interaction claim rather than another opinion about it.…
Second pass at: Programming during a large energy deficit Replied, post #13 · Nutrition & Training › Resistance training · 4 Jun 2026 · 14 likes Post #9 put the caveat in the right place and I want to underline it. Adding a reference point for Programming during a large energy. Mine is a single case, collected…
Second pass at: A pooled estimate that changed when one trial was added Replied, post #5 · Evidence › Meta-analyses · 14 May 2026 · 29 likes Picking up post #2: that is the part I would want checked first. A meta-analysis of four small trials is not stronger evidence than one adequately powered trial,…
Why the titration planner refuses to produce a schedule below a floor Replied, post #68 · Data & Tools › Calculators · 1 May 2026 · 11 likes Post #66 put the caveat in the right place and I want to underline it. What I can speak to on titration planner refuses is narrow, so I will keep it narrow rather than…
Adolescents: a distinct evidence base Started this topic · Clinical › Special populations · 28 Apr 2026 · 23 likes Adolescents: a distinct evidence base Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of…
Spreadsheets: an appreciation — what changed since Replied, post #23 · Lounge › Off topic · 20 Apr 2026 · 0 likes Agreed on Spreadsheets, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it does not, and…
Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #39 · Sourcing › Vendor reports · 22 Mar 2026 · 10 likes Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if the other mass is water, counter-ion, and excipient. Purity and content are…
Preprint servers and what screening they do — the long version Replied, post #5 · Evidence › Preprints · 11 Mar 2026 · 0 likes If you cite a preprint in a maintained document here, the convention is to label it in the sentence and to note the check date. The document review will catch the…
Where impurities in solid-phase peptide synthesis come from Replied, post #48 · Analytics › Impurities & related substances · 7 Mar 2026 · 1 like Taking impurities in solid-phase peptide synthesis seriously for a moment rather than deflecting: the honest position is that the community has observations and no…
The lowest dose that does anything: is that a real question? Replied, post #60 · Practice › Dosing & titration · 5 Mar 2026 · 13 likes Post #59 answers the question as asked. The question underneath it is different. Dose and effect are not linear across the studied range for every compound in this…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #5 · Sourcing › Logistics · 23 Feb 2026 · 9 likes Peak periods and public holidays affect this more than any other factor and are entirely predictable in advance.
Lipase elevation without symptoms: the interpretation problem Replied, post #24 · Clinical › Bloodwork · 22 Feb 2026 · 0 likes Thank you for the correction. I would rather find out here than later.
Follow-up: How to disagree with an answer you were given, well Started this topic · Start Here › How to Ask · 17 Feb 2026 · 1 like How to disagree with an answer you were given, well I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title and…
Coming back to: Reading a supplier's product description as a marketing document Replied, post #23 · Compounds › Other compounds · 13 Feb 2026 · 0 likes Colour in a lyophilised cake is worth noting for the less common compounds specifically, because some of them are genuinely not white and a member expecting white will…
Realistic expectations for strength while losing weight quickly Replied, post #59 · Nutrition & Training › Resistance training · 3 Feb 2026 · 1 like The reports here that state the programme, the load and the timeframe are useful. The ones that state an outcome are not.
Pharmacy supply in the UK and the questions you will be asked Replied, post #12 · Regional › UK & Ireland · 16 Jan 2026 · 9 likes I would be cautious about generalising from the pharmacy supply example above. It is a good example. It is one example.
A partial dose because the pen emptied mid-injection Replied, post #64 · Practice › Administration · 9 Jan 2026 · 2 likes Building on post #61 rather than restating it. One more thing on partial dose because the pen that took me far too long to see: the two figures people quote are not…
Coming back to: Private prescribing in the UK: what is actually involved Replied, post #50 · Regional › UK & Ireland · 9 Jan 2026 · 0 likes Ireland: the Health Products Regulatory Authority implements EU framework. Prescription-only. Reimbursement for weight management has been more restrictive than for…
Distinguishing expected GI effects from something that needs urgent attention Replied, post #49 · Practice › Side effects · 7 Jan 2026 · 0 likes Tracking severity on a simple scale with dates is far more useful than describing it afterwards. Memory smooths a symptom curve into a story that fits what you expected.
Pen mechanics when the cartridge is nearly empty — does this still hold? Replied, post #37 · Devices › Pens & autoinjectors · 1 Jan 2026 · 0 likes Post #33 describes the usual case. This is about the unusual one. Holding the pen in place for the stated count after the plunger stops is the manufacturer's answer to…
Journal club: LEADER as the historical anchor Replied, post #17 · Evidence › Journal club · 29 Dec 2025 · 16 likes Bookmarking this. I will come back when I have something worth adding.
Second pass at: What pooling buys you and what it destroys Replied, post #4 · Evidence › Meta-analyses · 23 Dec 2025 · 0 likes Nobody has said the unglamorous part of pooling buys yet, so: most of the variation is explained by things that are boring to write about and easy to check.
Appeal templates and why they are deliberately unemotional Replied, post #27 · Access › Insurance & coverage · 17 Dec 2025 · 15 likes Reimbursement changes: a compound covered one year might not be the next. A formulary decision in January can change by April. Checking again before refilling saves…
Persistent vomiting and the threshold for seeking help Replied, post #83 · Safety › Adverse events · 6 Dec 2025 · 12 likes The arithmetic in post #82 is right; the assumption feeding it is the part to check. Reporting to regulatory agencies: if you have had a serious event, reporting it to…
Tirzepatide's shorter half-life and its one practical consequence Replied, post #23 · Compounds › Tirzepatide · 6 Dec 2025 · 0 likes Post #20 answers the question as asked. The question underneath it is different. Categorical response thresholds — the proportion reaching ten, fifteen or twenty per…
Adsorptive losses at low concentration, and why dilute solutions are fragile Replied, post #3 · Practice › Storage & stability · 29 Nov 2025 · 1 like On the opening post — agreed on the reasoning, with one qualification. Taking adsorptive losses seriously for a moment rather than deflecting: the honest position is…
[2026 update] How much of the diluent volume the powder itself displaces Replied, post #27 · Practice › Reconstitution · 23 Nov 2025 · 23 likes If your arithmetic gives a volume smaller than one graduation on your syringe, the answer is a lower concentration rather than a more careful hand. Worth reading the…
Non-inferiority margins: how they are chosen and how they are abused Replied, post #16 · Evidence › Trials · 19 Nov 2025 · 1 like Risk of bias: structured appraisal of internal validity. Key things to assess: randomisation method (was it truly random or could someone predict the next assignment),…
Lurking for two months before posting: was that the right call? Replied, post #17 · Start Here › Welcome · 17 Nov 2025 · 11 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Stepping down deliberately, and how to do it without losing progress Replied, post #14 · Practice › Dosing & titration · 13 Nov 2025 · 3 likes Coming back to post #10, because the follow-up matters more than the original answer. Concentration and dose get conflated constantly in this subcategory. Changing how…
Tirzepatide's shorter half-life and its one practical consequence Replied, post #2 · Compounds › Tirzepatide · 12 Nov 2025 · 13 likes I had written a reply contradicting the opening post and deleted it. Here is what survived. SURPASS-2 compared tirzepatide with semaglutide 1.0 mg, the licensed…
Follow-up: The decimal-point error, and the habit that catches it Replied, post #97 · Practice › Reconstitution · 12 Nov 2025 · 3 likes Everything in post #96 holds. The case it does not cover is the one I have. Having read the whole decimal-point error thread before replying: the question in the first…
Sleep tracking data and its considerable limitations Replied, post #88 · Wellbeing › Sleep · 25 Oct 2025 · 27 likes Sleep quality changes reported here have several plausible contributors, and separating drug effects from weight change, from schedule change, and from anxiety is…
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #45 · Start Here › Welcome · 16 Oct 2025 · 0 likes Likes here mean "this helped", not "I agree". People like posts that argue against them, and that is deliberate.
Tracking that stops updating and then resumes — the long version Replied, post #26 · Sourcing › Logistics · 15 Oct 2025 · 29 likes Split shipments reduce single-point risk and increase the number of transits. Which trade is right depends on what you are protecting against. On reflection I would…
Reading an interaction checker output critically Replied, post #22 · Practice › Interactions · 14 Oct 2025 · 16 likes Reading an interaction checker output is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.
Compounds this community declines to help with, and why Replied, post #13 · Compounds › Other compounds · 25 Sep 2025 · 0 likes On analysis: unusual or modified sequences are exactly where a default reversed-phase method is least likely to be appropriate. A supplier that runs everything on one…
Retatrutide's phase 2 heart-rate signal and how to think about it Replied, post #3 · Compounds › Retatrutide · 15 Sep 2025 · 18 likes This follows post #2 rather than contradicting it. Discontinuation for adverse effects in phase 2 was not negligible at the higher doses. That figure belongs next to…
Particulates in a reconstituted solution: identifying the likely source Replied, post #5 · Analytics › Impurities & related substances · 3 Sep 2025 · 6 likes Oxidation at methionine and tryptophan: adds 16 per oxygen. Usually elutes earlier. Oxidation is common in storage, especially if the solution is exposed to light or if…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #42 · Analytics › HPLC & UHPLC · 3 Sep 2025 · 8 likes Carryover from a previous injection shows up as a small peak at the same retention time in a blank. A method report that includes a blank injection is telling you the…
Enforcement priorities versus written rules — does this still hold? Replied, post #31 · Sourcing › Regulatory · 27 Aug 2025 · 0 likes Post #28 and I disagree about the size of the effect, not about the direction. An honest declaration on Enforcement priorities: I have a prior here and it is strong…
Are there stupid questions here? A staff answer, at length Replied, post #96 · Start Here › Welcome · 21 Aug 2025 · 21 likes The moderation log is public. Every staff action is logged with the rule cited and the reasoning stated. If you get moderated, the explanation is there and it is worth…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #48 · Evidence › Journal club · 16 Aug 2025 · 31 likes Worth separating two things that post #46 runs together. Reading order that works for these sessions: registry entry, methods, baseline table, primary result, then…
Revisiting: Reading a denial letter as a specification for your appeal Replied, post #81 · Access › Insurance & coverage · 15 Aug 2025 · 28 likes Before the thread moves on from Reading a denial letter — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted from an…
Coming back to: When "no data" is the complete and final answer Replied, post #70 · Compounds › Other compounds · 3 Aug 2025 · 20 likes Narrowing post #68, because the general version has more than one answer. Thymosin alpha-1 has a regulatory history in several jurisdictions and a real clinical…
Revisiting: Reading a denial letter as a specification for your appeal Replied, post #62 · Access › Insurance & coverage · 30 Jul 2025 · 1 like Where the Reading a denial letter discussion usually stalls is that nobody wants to say "I do not know" and everyone is willing to say "it varies". Those are the same…
Antibiotics and a course of something with delayed emptying Replied, post #90 · Practice › Interactions · 14 Jul 2025 · 0 likes Picking up post #89: that is the part I would want checked first. Where I would push back on the antibiotics consensus is the confidence, not the direction. The…
How to read a forest plot, properly, from scratch Replied, post #4 · Evidence › Trials · 9 Jul 2025 · 3 likes Building on post #3 rather than restating it. Absolute and relative effects answer different questions. Write down the event rate in each arm and the difference between…
Checking someone else's arithmetic: a worked example thread Replied, post #65 · Practice › Reconstitution · 8 Jul 2025 · 1 like Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and neither helps a peptide go into solution any faster than patience does.
A report I filed that turned out to be wrong, and the correction Replied, post #113 · Sourcing › Vendor reports · 20 Jun 2025 · 14 likes Date the report: when the analysis was done matters. Material can degrade in storage. A report from two years ago is still useful but is not evidence about the current…
Storing a pen in use versus a pen unopened Replied, post #19 · Devices › Pens & autoinjectors · 9 Jun 2025 · 0 likes Adding the measurement that post #18 says would settle it. Travel with a pen raises a cold-chain question and a documentation question. The second is the one people…
The CagriSema phase 2 paper and what a fixed combination buys — the long version Replied, post #28 · Compounds › Cagrilintide & amylin analogues · 6 Jun 2025 · 20 likes The thing about CagriSema phase 2 paper that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result.
Second pass at: A history of disordered eating: proceeding carefully Replied, post #57 · Wellbeing › Mental health · 25 May 2025 · 0 likes Answering the question post #55 raises rather than the one it answers. Having read the whole history of disordered eating thread before replying: the question in the…
A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #58 · Practice › Reconstitution · 25 May 2025 · 28 likes Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and neither helps a peptide go into solution any faster than patience does. The general…
Travel coolers and how long they really hold — the long version Replied, post #14 · Devices › Cold chain · 21 May 2025 · 0 likes Answering the question post #10 raises rather than the one it answers. The documentation on Travel coolers is better than this thread and I say that as someone who has…
BPC-157: what the rodent literature actually shows, and what it does not — a second… Replied, post #45 · Compounds › Repair & healing peptides · 14 May 2025 · 13 likes TB-500 is usually the 7-residue actin-binding fragment of thymosin beta-4, not the full 43-residue protein. The two are routinely conflated in supplier documentation…
Second pass at: Retatrutide mass and identity: what a report should show Replied, post #18 · Compounds › Retatrutide · 9 Apr 2025 · 2 likes Heart rate increased in a dose-dependent way in the phase 2 work. That is not a footnote — it is one of the specific things phase 3 exists to characterise, and it is…
Adjudicated events and why the definition matters — the long version Replied, post #63 · Evidence › Trials · 24 Mar 2025 · 9 likes Reading back through the Adjudicated events threads from last year, the same three questions come up every time and only one of them has ever been answered properly.…
Why cagrilintide alone is discussed so much less than in combination Replied, post #16 · Compounds › Cagrilintide & amylin analogues · 23 Mar 2025 · 2 likes The honest summary of the evidence base: a coherent mechanism, good phase 2 data in combination, and much less standalone human data than the volume of discussion…
Oxidation and deamidation mass shifts, tabulated Replied, post #77 · Analytics › Mass spectrometry · 22 Mar 2025 · 4 likes On post #75 — agreed on the reasoning, with one qualification. For a compound with no reference standard in circulation, an observed mass is much more useful than an…
One lot is one lot: when a report becomes a pattern — the long version Replied, post #129 · Sourcing › Vendor reports · 18 Mar 2025 · 10 likes Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if the other mass is water, counter-ion, and excipient. Purity and content are…
Biased agonism: a real phenomenon, an over-used explanation Replied, post #89 · Pharmacology › Receptor biology · 13 Mar 2025 · 18 likes Picking up post #88: that is the part I would want checked first. Species differences in receptor pharmacology are substantial in this family, which is one reason…
Retatrutide dose escalation in the published trials Replied, post #4 · Compounds › Retatrutide · 10 Mar 2025 · 0 likes Retatrutide is investigational. Material obtained outside a clinical trial is research-use-only by definition, is not approved for human use, and carries no assurance…
Charge states for a 4 kDa peptide, worked through Replied, post #8 · marked as the solution · Analytics › Mass spectrometry · 2 Mar 2025 · 27 likes Where I would push back on the charge states consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.
Research-use-only status: what it means legally and practically — a second dataset Replied, post #93 · Compounds › Other compounds · 18 Feb 2025 · 0 likes Two sentences on Research-use-only status and then I will stop, because the rest is speculation and the thread is better without mine. What is documented is narrow.…
When "no data" is the complete and final answer Replied, post #79 · Compounds › Other compounds · 30 Jan 2025 · 32 likes A compound with no established assay is a compound where a certificate can say almost anything. That is not an accusation about anyone; it is a statement about what a…
Transit times by route, from a logged dataset — the long version Replied, post #52 · Sourcing › Logistics · 23 Jan 2025 · 12 likes Building on post #49 rather than restating it. Transit time quoted from dispatch and transit time quoted from order are different numbers, and suppliers vary in which…
Second pass at: Regression to the mean in progress reports Replied, post #23 · Research Methods › Statistics · 13 Jan 2025 · 31 likes I read post #21 twice before replying, because I had assumed the opposite. A request rather than an answer: could whoever has the primary source for Regression post it?…
Persistent vomiting and the threshold for seeking help — one year on Replied, post #43 · Safety › Adverse events · 23 Dec 2024 · 0 likes Post #39 describes the usual case. This is about the unusual one. Nothing here is medical advice, and in this subcategory the phrase is doing more work than in any…
Asking about a compound your prescriber has not heard of — one year on Replied, post #15 · Clinical › Prescriber conversations · 11 Dec 2024 · 1 like On post #11 — agreed on the reasoning, with one qualification. Asking about monitoring: understand what lab work will be done, how often, and what you will be monitored…
Injection-site reactions: describing them precisely enough to be useful Replied, post #63 · Practice › Side effects · 11 Dec 2024 · 1 like I read post #61 twice before replying, because I had assumed the opposite. The documentation on injection-site reactions is better than this thread and I say that as…
Meeting a protein target on a suppressed appetite — does this still hold? Replied, post #20 · Nutrition & Training › Protein & intake · 24 Nov 2024 · 19 likes Protein targets during weight loss: the standard recommendation is 1.6 to 2.2 grams per kilogram of body weight. Individual requirements vary but that range is a…
Transporting a vial for a weekend away Replied, post #40 · Practice › Storage & stability · 8 Nov 2024 · 1 like This follows post #37 rather than contradicting it. What I can speak to on transporting a vial is narrow, so I will keep it narrow rather than generalising from it.…
A page that has drifted out of date and needs a maintainer Replied, post #25 · Documentation › Wiki requests · 4 Nov 2024 · 13 likes A request that says what the page should not cover is unusually helpful, because scope creep is what kills these. I would not lead a decision with this, but I would not…
People with a low starting BMI: where the evidence stops Replied, post #11 · Clinical › Special populations · 29 Oct 2024 · 0 likes Pregnancy and breastfeeding are the clearest cases where the answer is that the trials excluded them and the labelling reflects that exclusion. It is the sort of thing…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #74 · Access › Shortages · 11 Oct 2024 · 4 likes I read post #70 twice before replying, because I had assumed the opposite. Switching presentation or strength during a shortage is a prescribing decision rather than a…
Follow-up: Where the four-week escalation interval comes from, and what it is not Replied, post #64 · Practice › Dosing & titration · 15 Sep 2024 · 0 likes Post #61 is the version of this I will quote in future. One addition. Two people in this thread mean different things by four-week escalation interval and are…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #52 · Analytics › COA interpretation · 12 Sep 2024 · 1 like My understanding of field-by-field walk through a certificate is a few years old and may have been superseded. If it has been, I would genuinely like to know rather…
SURPASS-2 and the comparator dose question that will not go away Replied, post #11 · Compounds › Tirzepatide · 6 Sep 2024 · 0 likes Taking post #8 at face value and following it one step further. SURPASS-2 compared tirzepatide with semaglutide 1.0 mg, the licensed diabetes dose at that time. It did…
Follow-up: Dead volume across syringe and needle combinations Replied, post #30 · Devices › Syringes & needles · 4 Sep 2024 · 11 likes If your calculated volume is under two graduations, choose a lower concentration rather than trying to read between marks. Precision comes from the preparation, not the…
When to suspect the method rather than the sample Replied, post #4 · Analytics › Method validation · 19 Aug 2024 · 12 likes Coming back to post #2, because the follow-up matters more than the original answer. The limit of quantitation determines what the impurity table can honestly contain.…
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one —… Replied, post #10 · Compounds › Oral incretins · 9 Aug 2024 · 26 likes PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for safety was demonstrated. The point estimates favoured the…
Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset Replied, post #4 · Compounds › Secretagogues & GH axis · 7 Aug 2024 · 22 likes A mass result for a short peptide is more discriminating than for a long one, because a single residue difference is a larger proportion of the total. That makes…
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #110 · Practice › Dosing & titration · 10 Jul 2024 · 8 likes Confirming post #109 from a second method, which matters more than confirming it from a second person. A missed dose in a weekly schedule is not a trough to chase. With…
How this community labels and discusses unrefereed work Replied, post #36 · Evidence › Preprints · 23 Jun 2024 · 1 like Taking post #35 at face value and following it one step further. Community labels has been discussed here with more heat than it deserves, mostly because two…
Assessing a warm arrival: the decision process — one year on Replied, post #37 · Sourcing › Logistics · 29 May 2024 · 4 likes Anyone deciding whether a delay is a problem should ask what would change if they waited another week. Usually the answer is nothing. Genuinely open to being wrong…