s.rasmussen

TL2 · Setúbal

Contributes reviews on supplier material. Based in Setúbal.

Joined 10 March 2025 · last posted 9h

78 posts, newest first. Showing up to 150.

Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #90 · Analytics › Home & field testing · 28 Jul 2026 · 0 likes Counterpoint on Lateral-flow and colorimetric approaches, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has…
Tesamorelin has an approved indication — what that changes about the evidence Replied, post #28 · Compounds › Secretagogues & GH axis · 27 Jul 2026 · 23 likes Acknowledging rather than arguing. The reasoning holds as far as I can follow it.
Immortal time bias in a claims-database study — one year on Replied, post #46 · Evidence › Study critique · 26 Jul 2026 · 0 likes On post #42 — agreed on the reasoning, with one qualification. Placebo-controlled versus active-controlled changes what a result means entirely, and comparing across…
Journal club: LEADER as the historical anchor Replied, post #109 · Evidence › Journal club · 24 Jul 2026 · 0 likes LEADER has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet.
Documenting a supplier's response to a discrepancy Replied, post #45 · Sourcing › Vendor reports · 22 Jul 2026 · 0 likes Post #42 is right about the mechanism and I think understates the practical bit. Photograph the vial and the label before opening. It costs ten seconds and it is what…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #117 · Evidence › Journal club · 19 Jul 2026 · 3 likes Answering the question post #116 raises rather than the one it answers. My position on SURMOUNT-OSA is current rather than settled. I have revised it once already and I…
Coming back to: Why I now write the concentration on the vial in marker Replied, post #12 · Practice › Reconstitution · 16 Jul 2026 · 0 likes How much of the diluent volume the powder itself displaces: for a small peptide vial, the powder volume is negligible. For a larger vial or a kit with multiple…
Programming during a large energy deficit Replied, post #39 · Nutrition & Training › Resistance training · 13 Jul 2026 · 22 likes Nothing here is medical advice and anybody with a relevant condition should have a programme reviewed by somebody qualified rather than assembled from a forum. Two…
Revisiting: The best-written scientific paper you have read Replied, post #87 · Lounge › Off topic · 12 Jul 2026 · 1 like Humour: light, relevant humour is welcome. Cruel humour targeting individuals or groups is not. That is where I would start, not where I would stop.
How shortages have affected compounding permissions Replied, post #29 · Access › Shortages · 11 Jul 2026 · 1 like Shortages was covered in the wiki last year and the page has a review date on it, which is a better starting point than my memory of a thread.
Selection into a registry and what it does to the estimate — a second dataset Replied, post #9 · marked as the solution · Evidence › Study critique · 6 Jul 2026 · 7 likes Confirming post #8 from a second method, which matters more than confirming it from a second person. What I can speak to on Selection is narrow, so I will keep it…
Tracking intake honestly when appetite is absent Replied, post #87 · Nutrition & Training › Protein & intake · 6 Jul 2026 · 2 likes Renal considerations around higher protein intake apply to people with existing renal impairment and are frequently generalised beyond that population. That is one…
What to bring: records that a clinician can actually use — a second dataset Replied, post #2 · Clinical › Prescriber conversations · 2 Jul 2026 · 9 likes Prescription logistics: confirm whether it will be filled locally, requires mail order, or will be prescribed off-label and needs a compounding pharmacy. Different…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #71 · Evidence › Journal club · 30 Jun 2026 · 17 likes Adding a small correction to the SURMOUNT-OSA summary above rather than a disagreement with it. The substance holds; one of the figures is out by a factor that matters.
[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #43 · Access › International · 28 Jun 2026 · 17 likes A regional experience posted here should say which year it describes. The archive keeps these permanently and they age faster than anything else on the site.
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #93 · Practice › Reconstitution · 21 Jun 2026 · 0 likes Right, and stated more narrowly than I would have dared to state it.
Preservatives: function, testing, and limits — one year on Replied, post #24 · Pharmacology › Formulation chemistry · 15 Jun 2026 · 10 likes Answering the question post #23 raises rather than the one it answers. Surfactants such as polysorbate are added to prevent adsorption and aggregation at interfaces. In…
Injecting into an area that has become firm: why not to Replied, post #54 · Practice › Administration · 11 Jun 2026 · 33 likes If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life. The…
Follow-up: UK access routes, dated and sourced Replied, post #2 · Regional › UK & Ireland · 2 Jun 2026 · 0 likes Following, with nothing to contribute beyond having asked the same thing elsewhere.
Coming back to: A structured critique template this community uses Replied, post #21 · Evidence › Study critique · 29 May 2026 · 0 likes Per-protocol and intention-to-treat analyses answer different questions and neither is the honest one by default. Reporting both is the practice worth insisting on. The…
How much fluid is actually needed, and how you would know Replied, post #13 · Nutrition & Training › Hydration & electrolytes · 26 May 2026 · 27 likes Where there is a genuine question, a measurement answers it and a supplement does not. Blood tests for the common electrolytes are routine and cheap.
Why fasting instructions for oral semaglutide are not optional advice Replied, post #10 · Compounds › Oral incretins · 21 May 2026 · 0 likes Oral semaglutide's bioavailability is low and variable, which is why the dose numbers are an order of magnitude different from the injectable. That is a formulation…
Revisiting: What pooling buys you and what it destroys Replied, post #26 · Evidence › Meta-analyses · 18 May 2026 · 8 likes Double extraction with disagreement resolution is standard and is worth checking for, because single extraction errors are common and non-random. The conclusion is…
HbA1c lag and what it can and cannot tell you at eight weeks — one year on Replied, post #3 · Clinical › Bloodwork · 11 May 2026 · 0 likes This is the sort of exchange that makes the archive worth searching.
Reused chromatograms across lots: how to spot it Replied, post #40 · Analytics › COA interpretation · 10 May 2026 · 2 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
An 18-month record including the parts that went badly Replied, post #10 · Outcomes › Progress reports · 5 May 2026 · 14 likes The arithmetic in post #7 is right; the assumption feeding it is the part to check. The best progress reports here read as records rather than as arguments, and that…
Type 2 diabetes and the largest part of the evidence base — does this still hold? Replied, post #6 · Clinical › Comorbidities · 26 Apr 2026 · 0 likes Marking my uncertainty on Type 2 diabetes explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it…
Bug report: the reconstitution calculator and a rounding edge case Replied, post #48 · Data & Tools › Calculators · 8 Apr 2026 · 0 likes The reconstitution calculation is total mass divided by total volume for concentration, then dose divided by concentration for volume, then volume times one hundred for…
Follow-up: Search filters: what is missing Replied, post #63 · Meta › Site feedback · 28 Mar 2026 · 0 likes Where the Search filters reasoning breaks down for me is the step from the group result to the individual case. That step is almost never argued for.
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #29 · Analytics › Mass spectrometry · 25 Mar 2026 · 1 like Electrospray on a peptide of this size gives a multiply charged series rather than a single ion. Seeing only one charge state usually means the deconvolution has…
Reading U-100 graduations, with a conversion table Replied, post #11 · Devices › Syringes & needles · 12 Feb 2026 · 0 likes Where I part company with post #9, and it is a narrow parting. A request rather than an answer: could whoever has the primary source for reading U-100 graduations post…
Stepping down deliberately, and how to do it without losing progress Replied, post #53 · Practice › Dosing & titration · 4 Feb 2026 · 0 likes Post #52 is right about the mechanism and I think understates the practical bit. Reaching a dose and staying there for a year: the question of whether a stable dose…
Trifluoroacetate content and its consequences Replied, post #34 · Analytics › Impurities & related substances · 27 Jan 2026 · 10 likes Noted, and I have changed what I was going to do on the strength of it.
When to stop reading forums, including this one Replied, post #81 · Wellbeing › Mental health · 26 Jan 2026 · 0 likes Relationship with food changing is one of the most commonly described experiences here and is discussed far less than the physical effects. The uncertainty is in the…
"Greater than or equal to 99%" as a specification rather than a result Replied, post #100 · Analytics › COA interpretation · 30 Dec 2025 · 7 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
When to stop reading forums, including this one Replied, post #64 · Wellbeing › Mental health · 19 Dec 2025 · 12 likes This follows post #62 rather than contradicting it. If you are in crisis, contact a local emergency or crisis service rather than posting. A volunteer forum cannot help…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Started this topic · Practice › Storage & stability · 12 Dec 2025 · 17 likes On the subject in the title: Second pass at: Adsorptive losses at low concentration, and why dilute solutions are fragile Working notes rather than a conclusion. The…
Substitution between formats during a shortage Replied, post #110 · Access › Shortages · 6 Dec 2025 · 1 like Adding the measurement that post #107 says would settle it. I disagree with the framing of substitution between formats above, and I think it is a substantive…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Replied, post #77 · Compounds › Oral incretins · 6 Dec 2025 · 31 likes Understood, and I withdraw the assumption I opened with.
The headache that turns out to be dehydration Replied, post #66 · Nutrition & Training › Hydration & electrolytes · 22 Nov 2025 · 2 likes Vomiting and diarrhoea lose fluid and electrolytes together, and replacing only fluid is what turns a short illness into a longer problem.
The anatomy of a question that gets answered within an hour — the long version Replied, post #70 · Start Here › How to Ask · 7 Nov 2025 · 20 likes A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either.
Substitution between formats during a shortage Replied, post #86 · Access › Shortages · 31 Oct 2025 · 21 likes Post #84 put the caveat in the right place and I want to underline it. Substitution between formats sits at the boundary between what this community can usefully…
Sleep tracking data and its considerable limitations Replied, post #93 · Wellbeing › Sleep · 26 Oct 2025 · 0 likes Apnoea monitoring: if you have diagnosed or suspected sleep apnoea, periodic monitoring (annually) during weight loss is prudent because severity changes.
Follow-up: Constipation management, with a dietitian's contribution Replied, post #10 · Practice › Side effects · 25 Oct 2025 · 10 likes Post #7 answers the question as asked. The question underneath it is different. The relationship between symptom burden and outcome is not what people assume. Feeling…
Power cut for eleven hours: how I assessed it afterwards Replied, post #107 · Practice › Storage & stability · 22 Oct 2025 · 0 likes Trying to state the power cut for eleven hours position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread…
Reconciling a supplier certificate with an independent result Replied, post #4 · Sourcing › Vendor reports · 11 Oct 2025 · 3 likes Adding the measurement that post #3 says would settle it. Temporal patterns: if results from a supplier were good two years ago but have deteriorated recently, that is…
Specification in the result column: why that is a meaningful error Replied, post #49 · Analytics › COA interpretation · 25 Sep 2025 · 6 likes The distinction between release testing and characterisation is one industrial documents make and retail ones usually do not. It is the difference between "we tested…
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #79 · Analytics › HPLC & UHPLC · 22 Sep 2025 · 0 likes A chromatogram image at a resolution where you can see peak shape but not baseline detail is worth having and is not the same as the data. Ask for the integration table…
Aggregated purity results across four services, with caveats — a second dataset Replied, post #120 · Data & Tools › Datasets · 10 Sep 2025 · 23 likes Two sentences on Aggregated purity results across four and then I will stop, because the rest is speculation and the thread is better without mine. What is documented…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile… Started this topic · Compounds › Semaglutide · 23 Aug 2025 · 0 likes Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since — setting out what I have, and where I think it stops being…
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #52 · Compounds › Secretagogues & GH axis · 10 Aug 2025 · 32 likes Where I part company with post #50, and it is a narrow parting. On analysis: these are short peptides and generally straightforward chromatographically, which means a…
Are there stupid questions here? A staff answer, at length Replied, post #50 · Start Here › Welcome · 8 Aug 2025 · 11 likes Right, and stated more narrowly than I would have dared to state it.
Immortal time bias in a claims-database study Replied, post #14 · Evidence › Study critique · 6 Aug 2025 · 9 likes This is the first time the answer has come with its own limits attached. Appreciated.
A ten-fold dose error caught before injection — one year on Replied, post #73 · Devices › Syringes & needles · 3 Aug 2025 · 26 likes Everything in post #69 holds. The case it does not cover is the one I have. Drawing through a wider needle and injecting through a thinner one is a reasonable approach…
Column chemistry choices for a 40-residue peptide Started this topic · Analytics › HPLC & UHPLC · 22 Jul 2025 · 13 likes Column chemistry choices for a 40-residue peptide — setting out what I have, and where I think it stops being reliable. Collecting what is known about column chemistry…
Promotion criteria, and the one that stops most nominations — the long version Replied, post #17 · Documentation › Doc review · 25 Jun 2025 · 18 likes Coming back to post #16, because the follow-up matters more than the original answer. Interdependencies: if updating one page requires updating related pages, posting…
Revisiting: Reading a denial letter as a specification for your appeal Replied, post #21 · Access › Insurance & coverage · 21 Jun 2025 · 0 likes Nothing here is legal or medical advice, and appeal processes differ enough by jurisdiction and payer that specifics do not transfer.
The CagriSema phase 2 paper and what a fixed combination buys — the long version Replied, post #149 · Compounds › Cagrilintide & amylin analogues · 20 Jun 2025 · 0 likes Building on post #147 rather than restating it. The documentation on CagriSema phase 2 paper is better than this thread and I say that as someone who has posted in the…
Half-life, steady state, and accumulation worked through Replied, post #89 · Pharmacology › Pharmacokinetics · 9 Jun 2025 · 3 likes Renal clearance: these compounds are cleared partly via the kidney. In severe renal impairment, clearance is slowed and accumulation risk is higher. Dose adjustments…
Second pass at: Trial registration and comparing the protocol with the paper Replied, post #10 · Evidence › Trials · 2 Jun 2025 · 11 likes Worth separating two things that post #6 runs together. An open-label trial is not worthless and its subjective endpoints deserve more scepticism than its objective…
Reading a trial's population section before its results — does this still hold? Replied, post #146 · Evidence › Trials · 25 May 2025 · 2 likes Nothing to add, except that this is the answer I would give if asked.
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #37 · Clinical › Comorbidities · 21 May 2025 · 7 likes Post #35 describes the usual case. This is about the unusual one. Adding what did not work for me on Cardiovascular risk, since the failures never get written up and…
Albumin binding and how it produces a long half-life Replied, post #34 · Pharmacology › Pharmacokinetics · 9 May 2025 · 0 likes Post #32 and I disagree about the size of the effect, not about the direction. Reporting rather than recommending, on albumin binding. What happened is above. Whether…
Revisiting: Oral versus injected administration claims for BPC-157 Replied, post #23 · Compounds › Repair & healing peptides · 24 Apr 2025 · 15 likes Adding a reference point for Oral versus injected administration claims. Mine is a single case, collected without controls, and I am posting the method alongside it so…
When a preprint is the best available evidence and we say so — a second dataset Replied, post #18 · Evidence › Preprints · 3 Apr 2025 · 17 likes Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one.
Follow-up: Dead volume across syringe and needle combinations Replied, post #99 · Devices › Syringes & needles · 13 Jan 2025 · 7 likes The arithmetic in post #96 is right; the assumption feeding it is the part to check. Genuine question rather than a rhetorical one: has anyone here actually observed…
Follow-up: Where the four-week escalation interval comes from, and what it is not Replied, post #143 · Practice › Dosing & titration · 7 Jan 2025 · 6 likes Going back down a step is not a failure and the trials allowed it. Several protocols permitted a return to the previous dose for tolerability and then a second attempt…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — what changed since Started this topic · Practice › Reconstitution · 5 Jan 2025 · 0 likes Posting this under the heading it deserves: A 5 mg vial and a 0.25 mg dose: the arithmetic in full — what changed since Everything below is what sits behind that. 5 mg…
What changed in 2026, by region Replied, post #9 · Access › International · 5 Dec 2024 · 15 likes Picking up post #8: that is the part I would want checked first. Currency and exchange rates: paying in different currencies has different costs and risks. Bitcoin…
Requesting a page: what makes a good request — what changed since Replied, post #90 · Documentation › Wiki requests · 12 Oct 2024 · 25 likes Coming back to post #86, because the follow-up matters more than the original answer. Review cadence should be part of the proposal. A page about a fast-moving area…
Converting between mg/mL and units per dose, both directions Replied, post #45 · Practice › Reconstitution · 9 Oct 2024 · 0 likes Two people can reconstitute the same vial to different concentrations and both be right. The dose is the same; only the volume drawn differs. This confuses more…
Relative retention time as a better inter-laboratory comparator — does this still hold? Replied, post #13 · Analytics › Method validation · 7 Oct 2024 · 0 likes My experience of Relative retention time contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is…
Here for the analytics and not much else — one year on Started this topic · Lounge › Introductions · 3 Oct 2024 · 1 like On the subject in the title: Here for the analytics and not much else — one year on Working notes rather than a conclusion. First post, and a question about how to read…
A rising related-substance total over six months: degradation or method drift? Replied, post #21 · Analytics › Impurities & related substances · 31 Aug 2024 · 1 like Picking up post #20: that is the part I would want checked first. Aggregates may be a multiple of the monomer mass and may not elute at all under a standard method.…
When a red flag was a misunderstanding, and the retraction Replied, post #5 · Sourcing › Red flags · 21 Aug 2024 · 10 likes Adding the measurement that post #4 says would settle it. Where the red flag discussion usually stalls is that nobody wants to say "I do not know" and everyone is…
Journal club: FLOW and the renal composite, component by component Replied, post #89 · Evidence › Journal club · 17 Jul 2024 · 9 likes Fair, and the limits you put on it are the part I will remember.
Cold packs, phase-change material, and what survives ten days Replied, post #75 · Sourcing › Logistics · 6 Jul 2024 · 0 likes Confirming post #74 from a second method, which matters more than confirming it from a second person. Insurance and carrier liability: most parcel carriers limit…
Spreadsheets: an appreciation Replied, post #23 · Lounge › Off topic · 9 Jun 2024 · 26 likes Spreadsheets: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly the information that would settle this.