g.verhoeven

TL2 · Breda

Contributes reviews on supplier material. Based in Breda.

Joined 10 November 2024 · last posted 6d

87 posts, newest first. Showing up to 150.

Fasting versus non-fasting and which tests care Replied, post #75 · Clinical › Bloodwork · 22 Jul 2026 · 11 likes This follows post #72 rather than contradicting it. A trend needs at least three points to be a trend. Two points are a line and a line through noise is still a line.…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #101 · Analytics › Impurities & related substances · 22 Jul 2026 · 0 likes Fair, and the limits you put on it are the part I will remember.
Primary endpoint hierarchies and why order matters — one year on Replied, post #55 · Evidence › Trials · 22 Jul 2026 · 7 likes The figure that circulates in coverage is almost always whichever estimand gives the larger effect. That is not fraud; it is selection, and it is why the paper matters…
Request: a per-category review queue Replied, post #91 · Meta › Feature requests · 9 Jul 2026 · 6 likes Post #90 is the version of this I will quote in future. One addition. Small correction to my own earlier position on per-category review queue. I had the units the…
How much context is too much context in a first post? Replied, post #38 · Start Here › How to Ask · 7 Jul 2026 · 28 likes Five questions in one post gets you one answer: the easiest one, usually not the one you needed most. Post them separately or pick the one that depends on the others…
Coming back to: Why a preprint's supplementary material is often the best part Replied, post #91 · Evidence › Preprints · 28 Jun 2026 · 8 likes Say it is a preprint in the first line rather than the last. Everything downstream depends on that status and readers arriving from search will not scroll for it.
What I would want from a home test that does not exist yet — what changed since Replied, post #70 · Analytics › Home & field testing · 26 Jun 2026 · 0 likes The honest cost comparison is a home kit against a single independent submission. For most people the second answers the question and the first answers a different,…
Reading U-100 graduations, with a conversion table Replied, post #35 · Devices › Syringes & needles · 23 Jun 2026 · 17 likes I keep a log for reading U-100 graduations specifically because my memory of it turned out to be systematically wrong in one direction. Six weeks of notes cost nothing…
A structured critique template this community uses — a second dataset Replied, post #16 · Evidence › Study critique · 21 Jun 2026 · 28 likes Confirming post #15 from a second method, which matters more than confirming it from a second person. Multiple comparisons: if a paper reports many outcomes, the chance…
Tesamorelin has an approved indication — what that changes about the evidence Replied, post #17 · Compounds › Secretagogues & GH axis · 20 Jun 2026 · 5 likes Appreciated. The plain phrasing does more work here than a longer post would.
Coming back to: Payment method and the leverage it gives you, ranked Replied, post #7 · Sourcing › Payments · 19 Jun 2026 · 13 likes Payment method is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says which…
Comparing prices across jurisdictions without misleading yourself Replied, post #78 · Access › Pricing · 14 Jun 2026 · 15 likes This is the answer, and the reason it is the answer is the more useful part.
Revisiting: PCOS and metabolic overlap: what is and is not studied Replied, post #39 · Clinical › Comorbidities · 10 Jun 2026 · 1 like Where two conditions pull in opposite directions, that is a clinical judgement rather than a lookup, and it is the kind of question a forum answers worst. I would want…
Dizziness on standing: the ordinary explanation first — one year on Replied, post #9 · Nutrition & Training › Hydration & electrolytes · 10 Jun 2026 · 7 likes Commercial rehydration formulations are designed for a specific purpose and are not equivalent to a sports drink, whatever the marketing suggests.
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #43 · Practice › Storage & stability · 4 Jun 2026 · 4 likes A request rather than an answer: could whoever has the primary source for reconstituted post it? I have seen the claim three times this month and each version had lost…
A single out-of-range value on an otherwise normal panel Replied, post #53 · Clinical › Bloodwork · 31 May 2026 · 19 likes Post #49 describes the usual case. This is about the unusual one. Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the…
Secretagogues and glucose tolerance: the mechanistic concern Replied, post #10 · Compounds › Secretagogues & GH axis · 22 May 2026 · 14 likes Worth separating two things that post #8 runs together. Research-use-only secretagogues are not approved for human use. That statement is doing real work in this…
Mass error in ppm: the arithmetic and the caveat — a second dataset Replied, post #2 · Analytics › Mass spectrometry · 21 May 2026 · 5 likes An acylated peptide has a mass that reflects the modification, so comparing against the mass of the unmodified backbone gives a mismatch that is not an error. If the…
Designing a personal experiment that could change your mind — one year on Replied, post #48 · Research Methods › N-of-1 designs · 19 May 2026 · 11 likes Reporting rather than recommending, on Designing a personal experiment. What happened is above. Whether it should have is a different question and not one I am…
How this community labels and discusses unrefereed work — the long version Replied, post #21 · Evidence › Preprints · 14 May 2026 · 5 likes Sample size and pre-registration are checkable in a preprint exactly as in a paper, and they carry the same weight. If it helps: the failure mode here is usually boring…
Request: show the solution author in the topic list — what changed since Replied, post #28 · Meta › Feature requests · 1 May 2026 · 10 likes Picking up post #27: that is the part I would want checked first. Request: an export of my own posts. Not for any dramatic reason — I want to search my own history…
When your prescriber and the evidence disagree Replied, post #10 · Clinical › Prescriber conversations · 23 Apr 2026 · 27 likes The documentation on prescriber is better than this thread and I say that as someone who has posted in the thread.
Blind submission and why it changes minds — the long version Replied, post #12 · Sourcing › Independent verification · 6 Apr 2026 · 2 likes Two people in this thread mean different things by Blind submission and are disagreeing about the definition while believing they are disagreeing about the facts. Worth…
Liver enzymes drifting down and what that usually means Replied, post #72 · Clinical › Bloodwork · 30 Mar 2026 · 29 likes The most useful thing anyone has posted about liver enzymes drifting in this category was a table of what had been measured and by whom. That is what I would want again.
What a good consultation looks like from the other side Replied, post #27 · Clinical › Prescriber conversations · 28 Mar 2026 · 0 likes Picking up post #26: that is the part I would want checked first. Something worth flagging about good consultation: the strongest-sounding claims in this thread are the…
Packaging that arrived damaged: documenting it properly — a second dataset Replied, post #58 · Sourcing › Logistics · 19 Mar 2026 · 2 likes Taking post #57 at face value and following it one step further. Peak periods and public holidays affect this more than any other factor and are entirely predictable in…
Revisiting: Journal club: SURMOUNT-1, read without the press release Replied, post #25 · Evidence › Journal club · 13 Mar 2026 · 14 likes Sensible. I would want the same detail before I acted on it either.
Search filters: what is missing Replied, post #30 · Meta › Site feedback · 24 Feb 2026 · 1 like Confirming post #27 from a second method, which matters more than confirming it from a second person. That would also be the fastest way for a new member to understand…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #103 · Documentation › Wiki requests · 22 Feb 2026 · 0 likes Translation suggestions: if a maintained page should exist in another language, suggesting it here helps the maintainers prioritise multilingual work.
Second pass at: Choosing a concentration on purpose rather than by accident Replied, post #8 · Practice › Reconstitution · 8 Feb 2026 · 13 likes A vial that will not fully dissolve: check in order: is the diluent genuinely room temperature (some preservatives crystallise in cold), is the vial being warmed gently…
Reading U-100 graduations, with a conversion table Replied, post #10 · Devices › Syringes & needles · 5 Feb 2026 · 1 like Check what the graduations actually say rather than what you expect. A syringe marked in units and one marked in millilitres look similar at a glance and are not the…
Coming back to: Reading a supplier's product description as a marketing document Replied, post #9 · Compounds › Other compounds · 29 Jan 2026 · 25 likes Worth separating two things that post #5 runs together. On analysis: unusual or modified sequences are exactly where a default reversed-phase method is least likely to…
A parcel stationary at a customs facility for nine days Replied, post #21 · Sourcing › Logistics · 18 Jan 2026 · 0 likes Parcel stationary would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
How to ask about something you suspect is a bad idea Replied, post #45 · Start Here › How to Ask · 17 Jan 2026 · 0 likes A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either.
Robustness: the parameters worth deliberately varying Replied, post #42 · Analytics › Method validation · 5 Dec 2025 · 18 likes Robustness testing deliberately varies the parameters most likely to drift — organic percentage, pH, temperature, flow — and shows the result does not. It is the part…
Research-use-only labelling: what it means and what it does not Replied, post #67 · Sourcing › Regulatory · 2 Dec 2025 · 28 likes Nothing in this subcategory is legal advice, and the members who work in regulated environments are the most careful to say so. It is the sort of thing that seems…
Tracking a preprint to publication: a worked example Replied, post #15 · Evidence › Preprints · 30 Nov 2025 · 18 likes Thank you for taking the time. That was more work than a reply usually is.
Follow-up: Glucagon receptor agonism in a weight-loss compound Replied, post #7 · Pharmacology › Receptor biology · 1 Nov 2025 · 0 likes Species differences in receptor pharmacology are substantial in this family, which is one reason rodent data has translated unevenly. The short answer was in the first…
Documentation that materially improves an appeal's chances Replied, post #44 · Access › Insurance & coverage · 29 Oct 2025 · 0 likes Post #41 is the version of this I will quote in future. One addition. Documentation your clinician can provide: letters from clinicians describing why standard…
Follow-up: What a seizure notice actually says Replied, post #23 · Sourcing › Logistics · 26 Oct 2025 · 14 likes Genuine question rather than a rhetorical one: has anyone here actually observed seizure notice, as opposed to read about it? The thread is long and I cannot tell.
Citing a preprint in a maintained document: our rule and its reasoning — does this still… Replied, post #34 · Evidence › Preprints · 28 Sep 2025 · 0 likes Where I part company with post #32, and it is a narrow parting. The reason Citing a preprint is hard to answer is that the obvious measurement and the relevant quantity…
Trial registration and comparing the protocol with the paper Replied, post #41 · Evidence › Trials · 25 Sep 2025 · 1 like What I can speak to on trial registration is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #30 · Wellbeing › Mental health · 25 Sep 2025 · 8 likes Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant.
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Replied, post #69 · Evidence › Journal club · 23 Sep 2025 · 13 likes Agreed on STEP 4, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it does not, and the…
Angle of injection and whether 90 degrees is always right Replied, post #22 · Practice › Administration · 14 Sep 2025 · 2 likes I read post #19 twice before replying, because I had assumed the opposite. Injection discomfort: comes from needle gauge (finer = less discomfort), volume (smaller =…
Second pass at: The mass-error checker and its intended scope Replied, post #13 · Data & Tools › Calculators · 7 Sep 2025 · 17 likes An update on my earlier mass-error checker post: the pattern held for another six weeks and then stopped, which I did not predict and cannot explain.
Fatigue in the first month: how much is the drug and how much is intake — what changed… Replied, post #69 · Practice › Side effects · 3 Sep 2025 · 0 likes Post #65 put the caveat in the right place and I want to underline it. Having read the whole Fatigue thread before replying: the question in the first post has not…
A ten-fold dose error caught before injection — one year on Replied, post #81 · Devices › Syringes & needles · 3 Aug 2025 · 9 likes This follows post #78 rather than contradicting it. A detachable luer needle plus hub can retain enough volume to matter. Whether it matters to you depends on your…
A field-by-field walk through a certificate of analysis Replied, post #22 · Analytics › COA interpretation · 14 Jul 2025 · 0 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
What a documentation review can and cannot tell you Replied, post #26 · Sourcing › Independent verification · 6 Jul 2025 · 0 likes Whatever the answer on documentation review turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, invite the…
[2026 update] US compounding rules and how they changed Replied, post #23 · Regional › North America · 6 Jul 2025 · 3 likes I came in to disagree and I am leaving without a disagreement.
Revisiting: What to include when your question involves arithmetic Replied, post #13 · Start Here › How to Ask · 5 Jul 2025 · 28 likes Post #12 is the version of this I will quote in future. One addition. A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the…
Interim analyses and stopping rules — does this still hold? Replied, post #14 · Evidence › Trials · 28 Jun 2025 · 0 likes The most useful reply I ever got about Interim analyses and stopping rules was a request to state my units. It sounds like pedantry and it has saved me twice.
Reverting an edit that had no revision note Replied, post #13 · Meta › Wiki maintenance · 26 Jun 2025 · 0 likes Revision disputes: if you disagree with an edit a maintainer made, discussing it here invites resolution rather than conflict. I checked the source rather than the…
Ipamorelin selectivity claims and where they came from Replied, post #50 · Compounds › Secretagogues & GH axis · 24 Jun 2025 · 0 likes Injection-site reactions are reported more often in this family than for the incretins. Whether that is the compounds or the preparations they are typically supplied in…
Follow-up: The lowest dose that does anything: is that a real question? Replied, post #22 · Practice › Dosing & titration · 16 Jun 2025 · 0 likes Picking up post #19: that is the part I would want checked first. Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add…
The C-cell question: rodent findings and their human context Replied, post #27 · Compounds › Semaglutide · 14 Jun 2025 · 13 likes Picking up post #26: that is the part I would want checked first. C-cell question is well covered in the tag pages, and the older discussions are better than the recent…
Coming back to: What published stability data actually covers, and what it does not Replied, post #60 · Practice › Storage & stability · 10 Jun 2025 · 15 likes Helpful, and short, which on this subject is harder than long.
Follow-up: Tracking intake honestly when appetite is absent Replied, post #11 · Nutrition & Training › Protein & intake · 3 Jun 2025 · 4 likes That is a cleaner way of putting what I was circling around.
Splitting a vial for two laboratories: how to do it without ruining both Replied, post #52 · Sourcing › Independent verification · 1 Jun 2025 · 5 likes If you are new and reading this thread for the answer to splitting a vial: the answer is conditional, the conditions are in the third reply, and the rest of the thread…
Comparing my trajectory with the trial curves, carefully Replied, post #9 · Outcomes › Progress reports · 29 May 2025 · 14 likes Picking up post #8: that is the part I would want checked first. The best progress reports here read as records rather than as arguments, and that difference is visible…
Trial registration and comparing the protocol with the paper Replied, post #10 · Evidence › Trials · 25 May 2025 · 0 likes Picking up post #8: that is the part I would want checked first. A comparator at less than its maximum licensed dose changes what a head-to-head result means. It does…
Checking someone else's arithmetic: a worked example thread Replied, post #50 · Practice › Reconstitution · 23 May 2025 · 27 likes Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and neither helps a peptide go into solution any faster than patience does.
Sequence verification for an obscure compound: how it is done Replied, post #39 · Compounds › Other compounds · 19 May 2025 · 19 likes Post #36 answers the question as asked. The question underneath it is different. Sequence verification: I have looked for the primary source twice and failed twice.…
Follow-up: Requesting a page: what makes a good request Replied, post #31 · Documentation › Wiki requests · 7 May 2025 · 19 likes I read post #29 twice before replying, because I had assumed the opposite. Format suggestions: if you think a maintained page could be clearer in its presentation…
Pages past their review date, listed — does this still hold? Replied, post #6 · Meta › Wiki maintenance · 5 May 2025 · 1 like Review dates: each maintained page has a review date (the date by which it should be checked). If a page is past its review date, flagging it here alerts the maintainer.
Obstructive sleep apnoea and a hard endpoint in this class Replied, post #63 · Clinical › Comorbidities · 20 Apr 2025 · 4 likes Obstructive sleep apnoea is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.
Revisiting: Oral versus injected administration claims for BPC-157 Replied, post #18 · Compounds › Repair & healing peptides · 13 Apr 2025 · 6 likes Small methodological point on Oral versus injected administration claims: repeating a measurement is cheap and resolves most of what is being argued about here at no…
Retatrutide dose escalation in the published trials Replied, post #123 · Compounds › Retatrutide · 12 Apr 2025 · 0 likes Post #119 and I disagree about the size of the effect, not about the direction. The hepatic-steatosis rationale follows directly from glucagon receptor agonism…
Hepatic steatosis: what the MASH trial evidence supports Replied, post #13 · Clinical › Comorbidities · 5 Apr 2025 · 0 likes Type 2 diabetes: the population with the largest evidence base for these compounds. The SURPASS and SUSTAIN programmes established glycaemic benefit. The renal and…
About the Wiki maintenance category Replied, post #4 · Meta › Wiki maintenance · 31 Mar 2025 · 1 like Suggestion for the wiki post above: it would be worth linking the two or three most-referenced topics in this category directly, since new members reliably ask for…
Biased agonism: a real phenomenon, an over-used explanation Replied, post #34 · Pharmacology › Receptor biology · 3 Mar 2025 · 0 likes Where a mechanism is proposed to explain an effect, the useful follow-up is what observation would distinguish it from the alternative. Most mechanistic threads here…
Reading order for a first week here, and what to skip until later Replied, post #20 · Start Here › Welcome · 1 Mar 2025 · 0 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Adducts: sodium, potassium, and the peak you did not expect Replied, post #18 · Analytics › Mass spectrometry · 24 Feb 2025 · 0 likes I read post #16 twice before replying, because I had assumed the opposite. Small methodological point on adducts: repeating a measurement is cheap and resolves most of…
[2026 update] Lipid changes during rapid weight loss: the expected trajectory Replied, post #54 · Clinical › Bloodwork · 12 Feb 2025 · 0 likes The thing about Lipid changes during rapid weight that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not…
Follow-up: Individual participant data versus aggregate data Replied, post #39 · Evidence › Meta-analyses · 9 Jan 2025 · 4 likes Where I have landed on Individual participant data versus aggregate, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone…
Follow-up: Individual participant data versus aggregate data Replied, post #4 · Evidence › Meta-analyses · 7 Jan 2025 · 0 likes Adding the measurement that post #3 says would settle it. What I would want before treating Individual participant data versus aggregate as settled: the method, the…
A promotion I argued against, and why I lost Replied, post #36 · Documentation › Doc review · 21 Dec 2024 · 0 likes Post #35 is right about the mechanism and I think understates the practical bit. Second-hand on promotion, so weight it accordingly — someone whose method I trust told…
Meeting a protein target on a suppressed appetite — does this still hold? Replied, post #37 · Nutrition & Training › Protein & intake · 4 Dec 2024 · 22 likes Coming back to post #33, because the follow-up matters more than the original answer. Adequate protein during a substantial deficit is the part of this conversation…
Coming back to: Recording a dissent on a document rather than suppressing it Replied, post #3 · Documentation › Doc review · 1 Nov 2024 · 18 likes Confirming the opening post from a second method, which matters more than confirming it from a second person. A review date is a commitment rather than a formality, and…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #17 · Evidence › Journal club · 26 Oct 2024 · 0 likes The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping.
Second pass at: Hoarding and why it makes a shortage worse Replied, post #89 · Access › Shortages · 12 Oct 2024 · 25 likes Planning around a known shortage window is easier than reacting to one, and the notices give advance warning more often than people expect. It is the sort of thing that…
Coming back to: Purity assay versus content assay: two different numbers Replied, post #10 · Analytics › COA interpretation · 8 Aug 2024 · 3 likes The honest answer on Purity assay versus content assay is that it depends, and the useful part is the list of what it depends on. Four items, in rough order of how much…
Oral contraceptives and delayed emptying: what the data shows Replied, post #48 · Practice › Interactions · 15 Jul 2024 · 6 likes Coming back to post #47, because the follow-up matters more than the original answer. Oral medications versus time: if you take an oral medication 30 minutes before…
Cold packs, phase-change material, and what survives ten days Replied, post #42 · Sourcing › Logistics · 25 Jun 2024 · 3 likes Something worth flagging about cold packs: the strongest-sounding claims in this thread are the ones with no source attached, which is the usual pattern and not a…
Promotion criteria, and the one that stops most nominations Replied, post #3 · Documentation › Doc review · 15 Jun 2024 · 2 likes I have no financial interest in anything named in this thread and I want to say so before I comment on promotion criteria, because it is the sort of subject where it…
The mass-error checker and its intended scope Replied, post #26 · Data & Tools › Calculators · 3 Jun 2024 · 30 likes On mass-error checker, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the…