t.brandt

TL2 · Uppsala

Contributes reviews on supplier material. Based in Uppsala.

Joined 2 December 2024 · last posted 1d

78 posts, newest first. Showing up to 150.

Seven-day rolling means and why weekly readings mislead Replied, post #118 · Outcomes › Progress reports · 26 Jul 2026 · 5 likes Post #117 answers the question as asked. The question underneath it is different. Weighing daily and reporting weekly is a better protocol than weighing weekly, because…
Coming back to: Why a preprint's supplementary material is often the best part Replied, post #112 · Evidence › Preprints · 21 Jul 2026 · 2 likes Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for…
A calculator that gives a right answer to the wrong question Replied, post #33 · Data & Tools › Calculators · 10 Jul 2026 · 10 likes Worth separating two things that post #31 runs together. Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #118 · Sourcing › Logistics · 30 Jun 2026 · 9 likes Right, and stated more narrowly than I would have dared to state it.
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #83 · Compounds › Semaglutide · 29 Jun 2026 · 26 likes Checked the semaglutide and gastric emptying claim against the primary source this morning. It survives, with a narrower scope than the version quoted here. Posting the…
Publication patterns in the BPC-157 literature, examined Replied, post #18 · Compounds › Repair & healing peptides · 21 Jun 2026 · 10 likes Confirming post #17 from a second method, which matters more than confirming it from a second person. Nothing in this subcategory is medical advice and several members…
Reference intervals: how they are constructed and why one in twenty flags — does this… Replied, post #3 · Clinical › Bloodwork · 7 Jun 2026 · 24 likes Where the Reference intervals reasoning breaks down for me is the step from the group result to the individual case. That step is almost never argued for.
A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #50 · Practice › Interactions · 24 May 2026 · 13 likes Anyone asking an interaction question should list everything, including the things they consider irrelevant. The irrelevant one is the answer more often than chance…
GLP-1 receptor distribution: central and peripheral Replied, post #53 · Pharmacology › Receptor biology · 20 May 2026 · 2 likes On post #49 — agreed on the reasoning, with one qualification. Receptor occupancy required for a clinical effect is not the same as full occupancy, and dose-response…
Why the titration planner refuses to produce a schedule below a floor Replied, post #72 · Data & Tools › Calculators · 11 May 2026 · 16 likes Post #69 is the version of this I will quote in future. One addition. Where I would push back on the titration planner refuses consensus is the confidence, not the…
Official shortage notices and what they authorise Replied, post #37 · Access › Shortages · 7 May 2026 · 9 likes Post #35 describes the usual case. This is about the unusual one. I have been on both sides of the official shortage notices argument in this category within eighteen…
Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #29 · Safety › Contraindications · 5 May 2026 · 33 likes Confirming post #26 from a second method, which matters more than confirming it from a second person. Disordered eating history: appetite suppression can trigger…
Adolescents: a distinct evidence base — one year on Replied, post #84 · Clinical › Special populations · 8 Apr 2026 · 5 likes Everything in post #82 holds. The case it does not cover is the one I have. The version of Adolescents that I was taught turned out to be a teaching simplification.…
Managing an unplanned gap in supply Replied, post #84 · Access › Shortages · 4 Apr 2026 · 32 likes Date any statement about supply. Positions change within weeks and the archive keeps posts permanently. I would want to see it done twice before believing it once.
Gastro-oesophageal reflux: improving or worsening? Replied, post #32 · Clinical › Comorbidities · 2 Apr 2026 · 18 likes Everything in post #28 holds. The case it does not cover is the one I have. My position on gastro-oesophageal reflux is current rather than settled. I have revised it…
[2026 update] Publication patterns in the BPC-157 literature, examined Replied, post #20 · Compounds › Repair & healing peptides · 1 Apr 2026 · 19 likes The pentadecapeptide sequence is short and stable enough to survive conditions that would degrade a larger peptide, which is one of the few things about it that is well…
An ABAB design with a data table and honest limitations — a second dataset Replied, post #50 · Research Methods › N-of-1 designs · 10 Mar 2026 · 30 likes Blinding yourself is harder than it sounds and is not impossible. Somebody else preparing labelled containers is the usual approach and it requires a second person you…
Air bubbles in a subcutaneous injection: the honest risk assessment — does this still… Replied, post #13 · Practice › Administration · 10 Mar 2026 · 10 likes Grateful for the specificity. Vague answers to this question are what sent me looking.
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #100 · Pharmacology › Pharmacokinetics · 7 Mar 2026 · 2 likes Accumulation at steady state: with a week-long half-life, steady-state concentration is reached around 4 to 5 half-lives (about 4 to 5 weeks). Before that,…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #10 · Evidence › Journal club · 4 Mar 2026 · 14 likes Narrowing post #9, because the general version has more than one answer. Orforglipron phase 2 is a good example of a question where the honest answer is boring and the…
Air bubbles in a subcutaneous injection: the honest risk assessment — does this still… Replied, post #7 · Practice › Administration · 2 Mar 2026 · 0 likes I disagree with the framing of Air bubbles above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be checked.…
The lowest dose that does anything: is that a real question? Replied, post #9 · Practice › Dosing & titration · 1 Mar 2026 · 11 likes If symptoms reset at each step, that is the expected pattern rather than a sign that the previous adaptation was imaginary. Every dose increase is a new exposure. I…
Revisiting: Absolute versus relative contraindications Replied, post #34 · Safety › Contraindications · 28 Feb 2026 · 22 likes Absolute versus relative contraindications: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly the information that…
Measurement error in a self-reported exposure Replied, post #49 · Evidence › Study critique · 24 Feb 2026 · 0 likes Building consensus on which criticisms matter: if everyone agrees that the sample size is small but only you think that affects the conclusion, maybe your criticism is…
Mass error in ppm: the arithmetic and the caveat Replied, post #95 · Analytics › Mass spectrometry · 15 Feb 2026 · 1 like The arithmetic for a doubly charged species is (M + 2 x 1.00728) / 2, and the analogous expression for higher charge states. Working it through once makes the reported…
Follow-up: Search filters: what is missing Replied, post #33 · Meta › Site feedback · 14 Feb 2026 · 0 likes Post #29 put the caveat in the right place and I want to underline it. Feedback on the search: the status filter is the most useful control on the site and it is the…
Can a home kit substitute for a laboratory report? A careful no Replied, post #125 · Analytics › Home & field testing · 4 Feb 2026 · 0 likes On post #121 — agreed on the reasoning, with one qualification. Reconstitution behaviour is a legitimate home observation. A cake that will not dissolve, a solution…
Coming back to: Semaglutide in people without diabetes: what the evidence base looks like Replied, post #26 · Compounds › Semaglutide · 23 Jan 2026 · 28 likes Cardiovascular data in people without diabetes is the specific contribution of SELECT, and it is worth being precise that the enrolled population had established…
Distinguishing expected GI effects from something that needs urgent attention Replied, post #78 · Practice › Side effects · 11 Jan 2026 · 24 likes The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by…
Storing lyophilised material long term: what governs the shelf life Replied, post #13 · Practice › Storage & stability · 2 Jan 2026 · 14 likes Understood. Thank you for being specific about the limits of it.
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Replied, post #9 · Data & Tools › Calculators · 25 Dec 2025 · 0 likes Post #7 answers the question as asked. The question underneath it is different. Tools that run entirely in the browser send nothing anywhere, which matters more to some…
The decimal-point error, and the habit that catches it Replied, post #13 · Practice › Reconstitution · 13 Dec 2025 · 0 likes Thank you for the correction. I would rather find out here than later.
Journal club: how we handle discontinuation in obesity trials — what changed since Replied, post #18 · Evidence › Journal club · 28 Nov 2025 · 11 likes Reading order that works for these sessions: registry entry, methods, baseline table, primary result, then abstract last. Reading the abstract first anchors everything…
Temperature loggers worth the money — the long version Replied, post #72 · Devices › Cold chain · 10 Nov 2025 · 7 likes An honest declaration on Temperature loggers worth the money: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather…
Sleep tracking data and its considerable limitations Replied, post #55 · Wellbeing › Sleep · 22 Oct 2025 · 0 likes Fatigue during the day and poor sleep at night are different problems with different causes and get merged in most accounts here. I am not the right person to answer…
Second pass at: Asking a follow-up: new topic or new reply? Replied, post #2 · Start Here › How to Ask · 19 Oct 2025 · 0 likes Thank you for taking the time. That was more work than a reply usually is.
Reading SURMOUNT-1 without the press release Replied, post #31 · Compounds › Tirzepatide · 11 Oct 2025 · 18 likes I read post #27 twice before replying, because I had assumed the opposite. SURMOUNT-4's randomised withdrawal design is the strongest available evidence about what…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #54 · Analytics › HPLC & UHPLC · 26 Sep 2025 · 18 likes Building on post #51 rather than restating it. Detection at 214 nanometres sees the peptide bond and therefore sees almost everything peptidic. At 280 it sees aromatic…
Batch date after test date, and other internal inconsistencies Replied, post #3 · Analytics › COA interpretation · 20 Sep 2025 · 16 likes Coming back to the opening post, because the follow-up matters more than the original answer. The distinction between release testing and characterisation is one…
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #91 · Evidence › Study critique · 15 Sep 2025 · 21 likes Taking post #90 at face value and following it one step further. A note on scope: what I am saying about Reverse causation applies to the case in the first post and I…
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #72 · Evidence › Study critique · 14 Sep 2025 · 1 like On post #70 — agreed on the reasoning, with one qualification. Generalisability and validity are separate axes. A trial can be internally impeccable and still tell you…
Airline travel with a temperature-sensitive injectable Replied, post #2 · Devices › Cold chain · 11 Sep 2025 · 6 likes Airline travel is a question about a distribution, not about a value, and treating it as a value is what produces the confident wrong answers.
Revisiting: Reading a denial letter as a specification for your appeal Replied, post #91 · Access › Insurance & coverage · 23 Aug 2025 · 19 likes Worth separating two things that post #89 runs together. The documentation on Reading a denial letter is better than this thread and I say that as someone who has…
When a preprint is the best available evidence and we say so Replied, post #45 · Evidence › Preprints · 11 Aug 2025 · 16 likes Peer review catches some things reliably — missing methods, unsupported conclusions, statistical mistakes of the obvious kind — and misses others routinely. Knowing…
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #83 · Clinical › Comorbidities · 31 Jul 2025 · 7 likes Nothing to add on the substance. Thank you for taking the question at face value.
Severe gastroparesis and why this class is a poor fit Replied, post #4 · Safety › Contraindications · 2 Jul 2025 · 11 likes Where I part company with the opening post, and it is a narrow parting. Severe hepatic impairment: less is known than for kidney disease. Extreme caution or…
Coming back to: Sample size calculations, read backwards from the published number Replied, post #49 · Evidence › Trials · 1 Jul 2025 · 6 likes This follows post #47 rather than contradicting it. Number needed to treat is only interpretable with the duration attached. The same NNT over one year and over five…
Reporting a disappointing outcome, and why it belongs here Replied, post #17 · Outcomes › Progress reports · 16 Jun 2025 · 23 likes Post #15 is the version of this I will quote in future. One addition. Genuine question rather than a rhetorical one: has anyone here actually observed reporting a…
BPC-157: what the rodent literature actually shows, and what it does not — a second… Replied, post #52 · Compounds › Repair & healing peptides · 31 May 2025 · 4 likes Reading rather than answering, but this is the post I would point somebody at.
Coming back to: Getting a referral rather than a refusal Replied, post #19 · Clinical › Prescriber conversations · 31 May 2025 · 0 likes Where I part company with post #17, and it is a narrow parting. On Getting a referral the community has more anecdote than the confidence in this thread implies, and I…
Substitution between formats during a shortage Replied, post #2 · Access › Shortages · 23 May 2025 · 15 likes A request rather than an answer: could whoever has the primary source for substitution between formats post it? I have seen the claim three times this month and each…
Regression to the mean in progress reports Replied, post #8 · Research Methods › Statistics · 10 May 2025 · 16 likes A standard deviation describes the spread of individuals and a standard error describes the precision of the mean. Quoting one where the other belongs changes the…
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #24 · Devices › Cold chain · 5 May 2025 · 0 likes Picking up post #22: that is the part I would want checked first. Airline travel: I would want to see the raw numbers rather than the summary before agreeing. Summaries…
[2026 update] Citation sweep results: how many references did not say what was claimed Replied, post #26 · Meta › Wiki maintenance · 1 May 2025 · 0 likes Genuine question rather than a rhetorical one: has anyone here actually observed Citation sweep results, as opposed to read about it? The thread is long and I cannot…
Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? Replied, post #64 · Evidence › Journal club · 28 Mar 2025 · 2 likes The arithmetic in post #63 is right; the assumption feeding it is the part to check. Whatever the answer on SUSTAIN 6 turns out to be, the method for getting there is…
When to suspect the method rather than the sample Replied, post #103 · Analytics › Method validation · 25 Mar 2025 · 0 likes Everything in post #102 holds. The case it does not cover is the one I have. A stability-indicating method is one demonstrated to resolve the analyte from its…
Biased agonism: a real phenomenon, an over-used explanation Replied, post #99 · Pharmacology › Receptor biology · 15 Mar 2025 · 11 likes Half-life extension by albumin binding through a fatty acid chain trades free fraction for duration. It is an engineering solution with a cost, and the cost is that the…
Introducing myself and asking whether my planned first topic belongs anywhere Replied, post #16 · Start Here › Welcome · 12 Mar 2025 · 0 likes Marked solutions are the site's way of saying that someone asked a good question and someone else gave an answer that actually worked. It is not a competition and it…
Research-use-only labelling: what it means and what it does not — the long version Replied, post #96 · Sourcing › Regulatory · 2 Mar 2025 · 1 like The bit of Research-use-only labelling that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and…
Adducts: sodium, potassium, and the peak you did not expect Replied, post #22 · Analytics › Mass spectrometry · 28 Feb 2025 · 3 likes This follows post #19 rather than contradicting it. Electrospray ionisation produces multiply charged ions. For a 4 kDa peptide you expect mostly 2+, 3+, and 4+ charge…
Transit times by route, from a logged dataset — the long version Replied, post #64 · Sourcing › Logistics · 26 Feb 2025 · 25 likes Second-hand on Transit times, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.
Adjudicated events and why the definition matters — the long version Replied, post #13 · Evidence › Trials · 16 Feb 2025 · 4 likes Confirming post #10 from a second method, which matters more than confirming it from a second person. The strongest argument against my own position on Adjudicated…
Second pass at: Regression to the mean in progress reports Replied, post #53 · Research Methods › Statistics · 12 Feb 2025 · 5 likes Multiple testing inflates the false-positive rate in a way that is entirely predictable and entirely correctable. The correction should be declared in advance. That…
Protein density versus volume when you cannot eat much Replied, post #65 · Nutrition & Training › Protein & intake · 4 Feb 2025 · 4 likes Adequate protein during a substantial deficit is the part of this conversation that gets least attention and probably deserves most.
Albumin binding and how it produces a long half-life Replied, post #3 · Pharmacology › Pharmacokinetics · 1 Feb 2025 · 12 likes No notes. Posting so the count is not one.
Journal club: SURMOUNT-1, read without the press release Replied, post #51 · Evidence › Journal club · 28 Jan 2025 · 0 likes This follows post #50 rather than contradicting it. Session format: read the paper before posting. The discussion is much better when everyone has. Start with the…
Coming back to: Recording a dissent on a document rather than suppressing it Replied, post #28 · Documentation › Doc review · 24 Jan 2025 · 23 likes On post #24 — agreed on the reasoning, with one qualification. Reviewing means reading it as somebody who needs the answer rather than as somebody checking it. Those…
Second pass at: Certificates issued by the seller versus by a laboratory Replied, post #10 · Analytics › COA interpretation · 15 Jan 2025 · 3 likes Picking up post #7: that is the part I would want checked first. A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is…
When "no data" is the complete and final answer Replied, post #49 · Compounds › Other compounds · 24 Dec 2024 · 10 likes Reading a supplier's product description as a marketing document: that is exactly what it is. The hyperbole, the mechanism written as fact, the theoretical benefits…
Identical chromatograms across two different lots Replied, post #59 · Sourcing › Red flags · 7 Dec 2024 · 20 likes I think the identical chromatograms question is answerable and has not been answered, which is a more optimistic position than most of this thread.
People with a low starting BMI: where the evidence stops Replied, post #21 · Clinical › Special populations · 5 Dec 2024 · 29 likes Nothing in this subcategory is medical advice and the questions asked here are precisely the ones that need an individual assessment. I am aware this is the third time…
A page that has drifted out of date and needs a maintainer Replied, post #35 · Documentation › Wiki requests · 2 Dec 2024 · 24 likes I had written a reply contradicting post #33 and deleted it. Here is what survived. Documents that are mostly a worked example age better than documents that are mostly…
Coming back to: The nausea timeline across the first four weeks, with a tabulated log Replied, post #30 · Practice › Side effects · 27 Nov 2024 · 0 likes Pancreatitis: a rare but serious event with a specific presentation (epigastric pain, back pain, elevated lipase). If this constellation of findings appears, stopping…
Choosing which test to pay for, given a fixed budget — does this still hold? Replied, post #25 · Sourcing › Independent verification · 9 Nov 2024 · 14 likes It does not extend to lots nobody has seen, it is not a recommendation, and it says nothing about anything other than what was measured.
Time to steady state after a dose increase Replied, post #112 · Pharmacology › Pharmacokinetics · 5 Nov 2024 · 6 likes Area under the curve is the exposure measure that matters for most effects in this class. Peak concentration matters more for tolerability. I would put the burden of…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #62 · Access › Shortages · 11 Oct 2024 · 4 likes The published shortage register maintained by the national regulator is the authoritative source here, and it is updated far more often than any thread.
Coming back to: Pricing far outside the range, in either direction Replied, post #17 · Sourcing › Red flags · 29 Jul 2024 · 13 likes Marking my place. If it changes for me I will come back and say so.
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #7 · Practice › Dosing & titration · 6 Jul 2024 · 17 likes The starting dose in most of these programmes is a tolerance step and produces little effect by design. Judging the compound at the starting dose is judging the wrong…