Thibodeau

TL3 Regular · Stavanger, NO

Journal club attendee. Interested in trial design more than in trial conclusions.

Joined 26 January 2025 · last posted 2d · groups: journal-club

125 posts, newest first. Showing up to 150.

Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #99 · Practice › Dosing & titration · 26 Jul 2026 · 0 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
What the GIP component of tirzepatide is thought to contribute, and how confident we can… Replied, post #17 · Compounds › Tirzepatide · 24 Jul 2026 · 0 likes Research-use-only tirzepatide is not approved for human use and is not made to pharmaceutical standards. Anyone discussing it here is describing what they did, not…
Publication patterns in the BPC-157 literature, examined Replied, post #43 · Compounds › Repair & healing peptides · 23 Jul 2026 · 31 likes Analytical identity of BPC-157: a 15-residue peptide with an unambiguous mass (≈1419.5 Da). Identity confirmation by LC-MS is trivially easy, which means there is no…
Blinding yourself: practical methods and their limits Replied, post #44 · Research Methods › N-of-1 designs · 20 Jul 2026 · 0 likes A rolling mean over several days is far more informative than any single reading for anything that varies day to day, which is nearly everything.
Common supplements people ask about, assessed one at a time Replied, post #60 · Practice › Interactions · 17 Jul 2026 · 0 likes Answering the question post #58 raises rather than the one it answers. Gastrointestinal symptoms from one compound can mask or mimic an interaction with another.…
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people… Replied, post #37 · Compounds › Repair & healing peptides · 17 Jul 2026 · 13 likes Taking post #36 at face value and following it one step further. Small methodological point on absence of controlled human data: repeating a measurement is cheap and…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #65 · Analytics › Home & field testing · 8 Jul 2026 · 15 likes I keep a log for consumer-accessible tests specifically because my memory of it turned out to be systematically wrong in one direction. Six weeks of notes cost nothing…
What I would want from a home test that does not exist yet Replied, post #31 · Analytics › Home & field testing · 8 Jul 2026 · 7 likes The most useful home practice is not a test at all: photograph the vial, the cake, the label and the document on arrival. It costs nothing and it is the evidence you…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #34 · Evidence › Journal club · 7 Jul 2026 · 10 likes This is the sort of exchange that makes the archive worth searching.
Journal club: LEADER as the historical anchor Replied, post #100 · Evidence › Journal club · 6 Jul 2026 · 14 likes I read post #96 twice before replying, because I had assumed the opposite. Where I would push back on the LEADER consensus is the confidence, not the direction. The…
Tracking a shortage from primary sources rather than rumour Replied, post #88 · Access › Shortages · 6 Jul 2026 · 13 likes Building on post #85 rather than restating it. The number people quote for tracking a shortage is a central estimate presented without its interval, and the interval is…
A structured critique template this community uses — a second dataset Replied, post #26 · Evidence › Study critique · 2 Jul 2026 · 18 likes Posting my structured critique template numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who…
Alcohol: what is documented and what is folklore Replied, post #88 · Practice › Interactions · 2 Jul 2026 · 0 likes Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this drug class already does that. The conservative position during titration…
Mass error in ppm: the arithmetic and the caveat — a second dataset Replied, post #15 · Analytics › Mass spectrometry · 2 Jul 2026 · 0 likes I read post #11 twice before replying, because I had assumed the opposite. Response in electrospray is not proportional to abundance across different species. Using…
Insurance and replacement policies, compared Replied, post #45 · Sourcing › Logistics · 26 Jun 2026 · 8 likes Taking post #42 at face value and following it one step further. Document outcomes rather than forecasting them. A forecast in this category reads as reassurance and is…
Prescription requirements and telehealth models — a second dataset Replied, post #69 · Sourcing › Regulatory · 17 Jun 2026 · 3 likes Generic or biosimilar entry depends on patent and exclusivity positions that are jurisdiction-specific and are frequently misreported.
Request: tag synonyms surfaced in search Replied, post #2 · Meta › Feature requests · 16 Jun 2026 · 5 likes Where I part company with the opening post, and it is a narrow parting. Tag synonyms surfaced in search is one of those subjects where the general answer and the answer…
Batch numbers that do not match the vial label — what changed since Replied, post #39 · Sourcing › Red flags · 16 Jun 2026 · 0 likes Where the same certificate image appears with different lot numbers, that is a documentation finding worth reporting with the images attached. Flagging that the sources…
Pooling trials with different estimands Replied, post #7 · Evidence › Meta-analyses · 4 Jun 2026 · 1 like Individual participant data pooling is a much stronger design than aggregate pooling and is rare because it requires cooperation rather than a search. Happy to be the…
Sample size intuition for a personal experiment — does this still hold? Replied, post #29 · Research Methods › Statistics · 3 Jun 2026 · 0 likes I would keep Sample size intuition and the decision it usually gets used for separate in this thread. They are related and they are not the same question, and merging…
Second pass at: When your prescriber and the evidence disagree Replied, post #30 · Clinical › Prescriber conversations · 2 Jun 2026 · 0 likes This follows post #28 rather than contradicting it. Worth stating the null on prescriber before we explain it: the observation may be nothing. That possibility deserves…
Compounds this community declines to help with, and why — does this still hold? Started this topic · Compounds › Other compounds · 2 Jun 2026 · 26 likes Compounds this community declines to help with, and why — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked.…
Documenting a supplier's response to a discrepancy Replied, post #6 · marked as the solution · Sourcing › Vendor reports · 31 May 2026 · 7 likes Where I part company with post #4, and it is a narrow parting. Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if the other mass is…
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #2 · Practice › Storage & stability · 31 May 2026 · 29 likes Beyond-use dating: the date after which a prepared solution should not be used. It is an estimate based on how fast the solution degrades under stated storage, not on…
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #118 · Pharmacology › Pharmacokinetics · 25 Apr 2026 · 3 likes Area under the curve is the exposure measure that matters for most effects in this class. Peak concentration matters more for tolerability. A modest claim, modestly…
Coming back to: Measurement error in a self-reported exposure Replied, post #11 · Evidence › Study critique · 22 Apr 2026 · 32 likes Attrition is the failure mode most likely to invalidate a result and the least likely to be discussed. Differential attrition between arms is the specific thing to look…
Follow-up: Sleep quality changes during weight loss Replied, post #6 · Wellbeing › Sleep · 17 Apr 2026 · 19 likes A sleep diary with times rather than impressions is the only way to tell a real change from a remembered one, and it takes a minute a day. Same conclusion as the reply…
Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #27 · Practice › Administration · 14 Apr 2026 · 0 likes I disagree with the framing of completing a dose above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be…
How to ask about something you suspect is a bad idea Replied, post #74 · Start Here › How to Ask · 8 Apr 2026 · 19 likes A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either. Worth checking against a second source…
Spike-and-recover accuracy for a peptide assay Replied, post #24 · Analytics › Method validation · 7 Apr 2026 · 10 likes My position on spike-and-recover accuracy is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.
Spike-and-recover accuracy for a peptide assay Replied, post #15 · Analytics › Method validation · 7 Apr 2026 · 22 likes What I would tell a new member reading about spike-and-recover accuracy for the first time: the confident posts are not the reliable ones, and the reliable ones are…
Prescription portability between countries Replied, post #2 · Access › International · 4 Apr 2026 · 27 likes I keep a log for prescription portability between countries specifically because my memory of it turned out to be systematically wrong in one direction. Six weeks of…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #75 · Clinical › Special populations · 16 Mar 2026 · 0 likes Helpful, and easy to find again, which is half of what a good reply is.
Secretagogues and glucose tolerance: the mechanistic concern — what changed since Started this topic · Compounds › Secretagogues & GH axis · 13 Mar 2026 · 13 likes Secretagogues and glucose tolerance: the mechanistic concern — what changed since Writing it up because I had to work it out twice and would rather nobody else did.…
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #37 · Pharmacology › Pharmacokinetics · 9 Feb 2026 · 1 like Post #35 and I disagree about the size of the effect, not about the direction. A note on scope: what I am saying about Washout applies to the case in the first post and…
MHRA statements, read directly Replied, post #84 · Regional › UK & Ireland · 7 Feb 2026 · 0 likes Narrowing post #83, because the general version has more than one answer. Occupational health screening: some UK occupations require medical checks. Disclosure of…
Reading an interaction checker output critically Replied, post #103 · Practice › Interactions · 27 Jan 2026 · 9 likes I had written a reply contradicting post #99 and deleted it. Here is what survived. Anyone asking an interaction question should list everything, including the things…
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Replied, post #5 · Clinical › Special populations · 20 Jan 2026 · 4 likes On the opening post — agreed on the reasoning, with one qualification. Where I would push back on the Pregnancy and pregnancy planning consensus is the confidence, not…
Angle of injection and whether 90 degrees is always right Replied, post #79 · Practice › Administration · 8 Jan 2026 · 0 likes I had written a reply contradicting post #77 and deleted it. Here is what survived. Pinching a fold is useful for lean tissue and unnecessary elsewhere. The point is to…
Follow-up: A supplier that answers analytical questions with restated claims Replied, post #35 · Sourcing › Red flags · 2 Jan 2026 · 2 likes That is a cleaner way of putting what I was circling around.
Reused chromatograms across lots: how to spot it — what changed since Replied, post #8 · Analytics › COA interpretation · 29 Dec 2025 · 25 likes Bookmarking this. I will come back when I have something worth adding.
Older adults, sarcopenia risk, and the trade-off nobody quantifies Replied, post #62 · Clinical › Special populations · 28 Dec 2025 · 0 likes This follows post #59 rather than contradicting it. A note on scope: what I am saying about older adults applies to the case in the first post and I would not extend it…
Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? Replied, post #23 · Compounds › Cagrilintide & amylin analogues · 26 Dec 2025 · 0 likes Sensible. I would want the same detail before I acted on it either.
Oral semaglutide bioavailability and its variability between people Replied, post #23 · Compounds › Oral incretins · 24 Dec 2025 · 0 likes Dose equivalence between oral and injectable formulations is not a simple conversion and no published factor should be used as one. The two were developed and titrated…
Why semaglutide solutions can look faintly opalescent and when that matters Replied, post #45 · Compounds › Semaglutide · 16 Dec 2025 · 1 like Semaglutide solutions is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says…
Revisiting: Language barriers in accessing a prescription abroad Replied, post #12 · Access › International · 14 Dec 2025 · 5 likes Where the Language barriers in accessing discussion usually stalls is that nobody wants to say "I do not know" and everyone is willing to say "it varies". Those are the…
Tracking a preprint to publication: a worked example Replied, post #46 · Evidence › Preprints · 4 Dec 2025 · 1 like Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for…
The headache that turns out to be dehydration Replied, post #76 · Nutrition & Training › Hydration & electrolytes · 30 Nov 2025 · 31 likes Adding salt to food is the intervention most consistently reported as helping and is also the one least likely to cause harm. The mechanism is plausible, which is not…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #28 · Pharmacology › Pharmacokinetics · 29 Nov 2025 · 15 likes Building on post #27 rather than restating it. Half-life is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.
Coming back to: Feature request: should a dose-equivalence tool exist at all? Replied, post #21 · Data & Tools › Calculators · 28 Nov 2025 · 2 likes A titration planner is a scheduling aid rather than a clinical recommendation, and any tool that presents one as the other is overstepping.
Severe gastroparesis and why this class is a poor fit — one year on Replied, post #11 · Safety › Contraindications · 25 Nov 2025 · 5 likes Genuine question rather than a rhetorical one: has anyone here actually observed Severe gastroparesis, as opposed to read about it? The thread is long and I cannot tell.
How to read a phase 2 result without treating it as a phase 3 result — what changed since Replied, post #18 · Compounds › Retatrutide · 23 Nov 2025 · 2 likes Heart rate increased in a dose-dependent way in the phase 2 work. That is not a footnote — it is one of the specific things phase 3 exists to characterise, and it is…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Replied, post #45 · Compounds › Oral incretins · 15 Nov 2025 · 13 likes Oral bioavailability is variable between people. Some people absorb well; others absorb poorly. That inter-individual variation is larger than with injectables and is…
Thyroid function tests during substantial weight change Replied, post #125 · Clinical › Bloodwork · 7 Nov 2025 · 17 likes The useful distinction on thyroid function tests during substantial is between what was measured and what was inferred from it. Both end up in the same sentence and…
What a purity-only report leaves out Replied, post #57 · Sourcing › Independent verification · 23 Oct 2025 · 31 likes Post #53 describes the usual case. This is about the unusual one. A record with four results over sixteen months is a thin record rather than a bad one, and the honest…
Turnaround times and what they mean for a decision Started this topic · Sourcing › Independent verification · 19 Oct 2025 · 5 likes Turnaround times and what they mean for a decision Writing it up because I had to work it out twice and would rather nobody else did. A question about turnaround times…
Where impurities in solid-phase peptide synthesis come from Replied, post #13 · Analytics › Impurities & related substances · 13 Oct 2025 · 9 likes Confirming post #11 from a second method, which matters more than confirming it from a second person. Relative response factors mean impurities are not detected in…
Thyroid function tests during substantial weight change Replied, post #94 · Clinical › Bloodwork · 13 Oct 2025 · 25 likes Summarising the thyroid function tests during substantial thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the…
Managing an unplanned gap in supply — what changed since Replied, post #86 · Access › Shortages · 12 Oct 2025 · 1 like What I would want before treating Managing an unplanned gap as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three…
Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a… Replied, post #31 · Analytics › Method validation · 9 Oct 2025 · 16 likes Answering the question post #29 raises rather than the one it answers. Offering a way to settle Specificity rather than another opinion about it. Two measurements,…
Why one laboratory's 98.4% and another's 96.1% may not contradict Replied, post #24 · Analytics › Method validation · 4 Oct 2025 · 21 likes Transfer between laboratories: a method can be transferred from one lab to another, but the receiving lab needs to demonstrate that they can achieve the same…
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Replied, post #29 · Clinical › Special populations · 1 Oct 2025 · 19 likes On Older adults I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how threads…
Coming back to: Over-dilution: when your dose falls below one readable graduation Replied, post #62 · Practice › Reconstitution · 30 Sep 2025 · 15 likes The arithmetic in post #60 is right; the assumption feeding it is the part to check. Arithmetic step by step: a 5 mg vial with 2 mL of diluent gives (5 mg) / (2 mL) =…
What a purity-only report leaves out Replied, post #26 · Sourcing › Independent verification · 26 Sep 2025 · 6 likes I read post #24 twice before replying, because I had assumed the opposite. The arithmetic on purity-only is the easy part and it is where the errors are, which is an…
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #67 · Analytics › HPLC & UHPLC · 12 Sep 2025 · 21 likes Bookmarking this. I will come back when I have something worth adding.
Aggregated purity results across four services, with caveats — a second dataset Replied, post #57 · Data & Tools › Datasets · 8 Sep 2025 · 1 like Confirming post #56 from a second method, which matters more than confirming it from a second person. The arithmetic on Aggregated purity results across four is the…
Follow-up: Journal club: orforglipron phase 2 and the non-peptide question Replied, post #77 · Evidence › Journal club · 5 Sep 2025 · 18 likes Post #75 put the caveat in the right place and I want to underline it. The question underneath orforglipron phase 2 is usually "how would I tell?" rather than "what is…
Reading SURMOUNT-1 without the press release — one year on Replied, post #6 · Compounds › Tirzepatide · 4 Sep 2025 · 1 like The apnoea-hypopnoea index used in SURMOUNT-OSA is an objective measurement rather than a symptom scale, which is why that trial carries more weight than its size…
Confounding by indication, explained with a concrete example Replied, post #9 · Evidence › Study critique · 31 Aug 2025 · 1 like Confirming post #6 from a second method, which matters more than confirming it from a second person. Statistical significance and clinical importance are different and…
A ten-fold dose error caught before injection Replied, post #74 · Devices › Syringes & needles · 31 Jul 2025 · 8 likes Adding the boring version of ten-fold dose error caught, because the interesting version keeps getting posted and the boring one is usually right. Check the ordinary…
Coming back to: Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #32 · Compounds › Cagrilintide & amylin analogues · 22 Jul 2025 · 9 likes Reading rather than contributing, but this is the most useful thread I have found on it.
Coming back to: What published stability data actually covers, and what it does not Replied, post #86 · Practice › Storage & stability · 13 Jul 2025 · 5 likes Building on post #85 rather than restating it. Published stability data actually covers: I have looked for the primary source twice and failed twice. Either it does not…
Risk-of-bias tools and the judgement they conceal Replied, post #7 · Evidence › Meta-analyses · 8 Jul 2025 · 7 likes Noted, and thank you for writing it out rather than summarising it.
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #2 · Analytics › HPLC & UHPLC · 4 Jul 2025 · 23 likes On integration: where the baseline is drawn matters more than most people realise. On a clean chromatogram with well-resolved peaks the choice is inconsequential. On a…
Asking about a compound your prescriber has not heard of Replied, post #69 · Clinical › Prescriber conversations · 18 Jun 2025 · 0 likes I had written a reply contradicting post #66 and deleted it. Here is what survived. Prescription logistics: confirm whether it will be filled locally, requires mail…
[2026 update] An appeal that failed, and what I would do differently Replied, post #76 · Access › Insurance & coverage · 12 Jun 2025 · 16 likes Formulary status: the list of covered medications and the tier (how much you pay) they are on. Checking the current formulary before going to a clinic appointment saves…
Follow-up: Tracking intake honestly when appetite is absent Replied, post #47 · Nutrition & Training › Protein & intake · 9 Jun 2025 · 0 likes Meeting protein targets on suppressed appetite: this is where the practical difficulty lies. Eating more protein when appetite is suppressed is genuinely hard.…
Journal club: the CagriSema phase 2 combination paper — a second dataset Replied, post #23 · Evidence › Journal club · 2 Jun 2025 · 21 likes Worth separating two things that post #19 runs together. TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be attributed to it because it has not…
Why one laboratory's 98.4% and another's 96.1% may not contradict Replied, post #8 · Analytics › Method validation · 30 May 2025 · 15 likes Transfer between laboratories: a method can be transferred from one lab to another, but the receiving lab needs to demonstrate that they can achieve the same…
Needle changes between doses on a reusable pen — does this still hold? Replied, post #2 · marked as the solution · Devices › Pens & autoinjectors · 28 May 2025 · 11 likes The instruction leaflet for a licensed pen is a genuinely good technical document and is almost never read past the first page. It answers most of what gets asked here.
[2026 update] Clearance pathways and what renal impairment changes Replied, post #11 · Pharmacology › Pharmacokinetics · 22 May 2025 · 0 likes Practical answer on Clearance pathways, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide whether the…
Research-use-only labelling: what it means and what it does not — the long version Replied, post #144 · Sourcing › Regulatory · 4 May 2025 · 0 likes Adding the measurement that post #141 says would settle it. Labelling and intended use: a compound sold as "research-use-only" does not change its pharmacology if…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #75 · Compounds › Tirzepatide · 2 May 2025 · 25 likes Building on post #74 rather than restating it. Heart rate rises modestly across this class, tirzepatide included. It is consistent, small, and worth knowing about…
Fibre intake when total intake falls, and the constipation link Replied, post #53 · Nutrition & Training › Protein & intake · 13 Apr 2025 · 29 likes The mechanism is not mysterious. Substantial energy restriction with inadequate protein and no resistance stimulus loses lean tissue as well as fat. If this contradicts…
Follow-up: What other technical communities get right that we do not Replied, post #66 · Lounge › Off topic · 13 Apr 2025 · 3 likes Not a technical point, just an observation: the register here holds because people correct themselves in public and nobody scores points off it. That is rarer than the…
Follow-up: What other technical communities get right that we do not Replied, post #57 · Lounge › Off topic · 3 Apr 2025 · 9 likes Unserious but true: I can now identify a certificate template at a glance and I have no professional use for that skill whatsoever. Written in the hope of being told…
Obstructive sleep apnoea and a hard endpoint in this class Replied, post #35 · Clinical › Comorbidities · 16 Mar 2025 · 0 likes Everything in post #33 holds. The case it does not cover is the one I have. Comorbidity control: if a comorbidity (high blood pressure, high lipids) is not adequately…
Maintainer handover: how it works Replied, post #39 · Meta › Wiki maintenance · 16 Mar 2025 · 0 likes I would rather this thread reach "we do not know" about maintainer handover than reach a confident answer that nobody can support when asked.
One lot is one lot: when a report becomes a pattern — the long version Replied, post #24 · Sourcing › Vendor reports · 15 Mar 2025 · 13 likes Post #22 answers the question as asked. The question underneath it is different. Where you have no independent result, a documentation report is still worth filing:…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #120 · Sourcing › Regulatory · 4 Mar 2025 · 0 likes Taking post #119 at face value and following it one step further. Primary documents matter: regulatory positions are published in official documents. Reading the…
Validating a method you did not develop — does this still hold? Replied, post #46 · Analytics › Method validation · 26 Feb 2025 · 12 likes Validation is compound-specific and matrix-specific. A method validated for one peptide is a starting point for another and not a validated method for it.
What the published dose-response for semaglutide actually looks like above 2.4 mg — a… Replied, post #65 · Compounds › Semaglutide · 16 Feb 2025 · 1 like Adding a small correction to the published dose-response for semaglutide summary above rather than a disagreement with it. The substance holds; one of the figures is…
Talking to a therapist about this specifically — does this still hold? Replied, post #17 · Wellbeing › Mental health · 14 Feb 2025 · 10 likes Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it…
Consistent declarations and why they matter more than clever ones Replied, post #14 · Sourcing › Logistics · 10 Feb 2025 · 1 like Coming back to post #10, because the follow-up matters more than the original answer. Document outcomes rather than forecasting them. A forecast in this category reads…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #27 · Practice › Reconstitution · 6 Feb 2025 · 9 likes Confirming post #24 from a second method, which matters more than confirming it from a second person. Small methodological point on 5 mg vial: repeating a measurement…
Journal club: STEP 4 and what a withdrawal design can prove — one year on Replied, post #27 · Evidence › Journal club · 22 Jan 2025 · 28 likes Coming back to post #25, because the follow-up matters more than the original answer. Nobody has said the unglamorous part of STEP 4 yet, so: most of the variation is…
A supplier that answers analytical questions with restated claims Replied, post #10 · Sourcing › Red flags · 14 Jan 2025 · 25 likes Coming back to post #8, because the follow-up matters more than the original answer. On supplier I would separate what is worth knowing from what is worth acting on.…
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated… Replied, post #10 · Compounds › Secretagogues & GH axis · 30 Dec 2024 · 17 likes Practical experience of GHRH analogues versus ghrelin mimetics, offered as one case with the conditions stated, not as a general finding. Conditions first, because they…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #74 · Evidence › Journal club · 28 Dec 2024 · 3 likes I would put moderate confidence on the mainstream reading of SURPASS-2 and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.
Follow-up: Tirzepatide's shorter half-life and its one practical consequence Replied, post #97 · Compounds › Tirzepatide · 19 Dec 2024 · 2 likes Post #95 is the version of this I will quote in future. One addition. SURPASS-2 compared tirzepatide with semaglutide 1.0 mg, the licensed diabetes dose at that time.…
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #12 · Compounds › Semaglutide · 18 Dec 2024 · 12 likes Post #9 is right about the mechanism and I think understates the practical bit. The opalescent appearance in semaglutide solutions is occasionally noted and the…
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #5 · Compounds › Semaglutide · 18 Dec 2024 · 13 likes I have no financial interest in anything named in this thread and I want to say so before I comment on Molecular mass of semaglutide, because it is the sort of subject…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #36 · Compounds › Cagrilintide & amylin analogues · 16 Dec 2024 · 0 likes The thing about amylin analogue mechanism that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result.
Body image changing more slowly than the body Replied, post #2 · Wellbeing › Mental health · 9 Dec 2024 · 4 likes Narrowing the opening post, because the general version has more than one answer. Social and relationship impacts: weight change affects how others perceive and…
What would change my mind about repair peptides: a specific answer — one year on Replied, post #9 · Compounds › Repair & healing peptides · 28 Nov 2024 · 15 likes Reading a preclinical wound-healing model: the model shows whether a mechanism is plausible in a specific context. It does not show magnitude of effect in humans, does…
A promotion I argued against, and why I lost Replied, post #15 · Documentation › Doc review · 27 Nov 2024 · 0 likes Promotion was covered in the wiki last year and the page has a review date on it, which is a better starting point than my memory of a thread.
Follow-up: Recovery when intake is low: what to cut first Replied, post #21 · Nutrition & Training › Resistance training · 13 Nov 2024 · 15 likes Adding a note of thanks rather than an opinion. I did not know most of that.
Time to steady state after a dose increase Replied, post #55 · Pharmacology › Pharmacokinetics · 3 Nov 2024 · 25 likes Accumulation at steady state: with a week-long half-life, steady-state concentration is reached around 4 to 5 half-lives (about 4 to 5 weeks). Before that,…
Time to steady state after a dose increase Replied, post #11 · Pharmacology › Pharmacokinetics · 2 Nov 2024 · 16 likes Volume of distribution: the theoretical volume the drug distributes into. For albumin-binding compounds, volume is reduced compared to drugs that do not bind protein.…
[2026 update] Step therapy requirements and how to satisfy them Replied, post #5 · Access › Insurance & coverage · 25 Oct 2024 · 20 likes I disagree with the framing of Step therapy requirements above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it…
When a red flag was a misunderstanding, and the retraction Replied, post #31 · Sourcing › Red flags · 10 Oct 2024 · 4 likes Nothing here should be read as an accusation against a named company, and the guidelines exist so that reports remain reports. I keep a log of this specifically because…
Blind submission and why it changes minds Replied, post #67 · Sourcing › Independent verification · 21 Sep 2024 · 16 likes For anyone finding this later: the short answer on blind submission is that it depends on one thing, and the rest of the thread is people identifying which thing.
Progressive overload when the scale is falling — one year on Replied, post #8 · Nutrition & Training › Resistance training · 27 Aug 2024 · 0 likes Post #5 is right about the mechanism and I think understates the practical bit. Nothing here is medical advice and anybody with a relevant condition should have a…
Correlation in a self-tracked dataset: what it can support Replied, post #159 · Research Methods › Statistics · 26 Aug 2024 · 26 likes I had written a reply contradicting post #156 and deleted it. Here is what survived. Working an example through by hand once makes any of these concepts stick better…
Hepatic effects of glucagon receptor agonism: the mechanistic worry Started this topic · Compounds › Retatrutide · 22 Aug 2024 · 25 likes Posting this under the heading it deserves: Hepatic effects of glucagon receptor agonism: the mechanistic worry Everything below is what sits behind that. Something…
High-resolution MS on aggregates and what it can see — one year on Replied, post #46 · Analytics › Mass spectrometry · 19 Aug 2024 · 3 likes Quantitation by MS: most quantitation is done by LC-UV detection at 214 nm, not by MS, because extinction coefficients are better known. MS can quantify if an internal…
Request: a diff view for wiki revisions Replied, post #5 · Meta › Feature requests · 12 Aug 2024 · 4 likes I read post #3 twice before replying, because I had assumed the opposite. Community support: if other people support your request, they can reply with "+1" or "I would…
Chronic kidney disease and the FLOW result Replied, post #9 · Clinical › Comorbidities · 12 Aug 2024 · 0 likes Chronic kidney disease: compounds in this class have renal benefit in people with kidney disease. The benefit appears to be additive to other renal-protective agents,…
Pancreatitis history and the risk calculus — a second dataset Replied, post #4 · Safety › Contraindications · 8 Aug 2024 · 0 likes Picking up the opening post: that is the part I would want checked first. What I would check first on Pancreatitis history is whether the thing being measured moved or…
Circumference measurements as a poor man's composition estimate Replied, post #33 · Outcomes › Body composition · 1 Aug 2024 · 0 likes Agreed on circumference measurements, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it…
Guidelines revision: what changed and why Replied, post #61 · Meta › Announcements · 26 Jul 2024 · 8 likes Worth saying publicly: stepping back cleanly and handing over is a service. Documents with an absent maintainer go wrong quietly, which is the worst way for them to go…
How to ask for a dose change without antagonising anyone Replied, post #6 · Clinical › Prescriber conversations · 17 Jul 2024 · 1 like A question phrased as "what would you want to see before considering X" is answerable and is not a request for X. Not the whole picture, but the part of it I can speak…
Cold packs, phase-change material, and what survives ten days Replied, post #110 · Sourcing › Logistics · 16 Jul 2024 · 23 likes Genuine question rather than a rhetorical one: has anyone here actually observed cold packs, as opposed to read about it? The thread is long and I cannot tell.
How this community labels and discusses unrefereed work Replied, post #70 · Evidence › Preprints · 8 Jul 2024 · 4 likes Discussing preprints in this community: bring them in for early discussion, label them clearly as preprints, invite peer critique, and be prepared for the discussion to…
The mass-error checker and its intended scope Replied, post #13 · Data & Tools › Calculators · 26 May 2024 · 13 likes Post #10 answers the question as asked. The question underneath it is different. The confident answers on mass-error checker and the well-sourced answers are not the…