f.fontaine

TL2 · Curitiba

Contributes reviews on supplier material. Based in Curitiba.

Joined 2 June 2025 · last posted 8d

89 posts, newest first. Showing up to 150.

Which categories are strict and which are relaxed, honestly Replied, post #32 · Start Here › Welcome · 20 Jul 2026 · 2 likes The category structure looks heavier than it is. There are twenty top-level categories and you will use three of them. Find those three, mute the rest for a month, and…
Insomnia at a dose step: reported experiences — the long version Replied, post #49 · Wellbeing › Sleep · 20 Jul 2026 · 2 likes Trying to state the Insomnia position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes that test.
Request: tag synonyms surfaced in search Replied, post #17 · Meta › Feature requests · 13 Jul 2026 · 2 likes Understood. Thank you for being specific about the limits of it.
Coming back to: Payment method and the leverage it gives you, ranked Replied, post #19 · Sourcing › Payments · 13 Jul 2026 · 0 likes Bookmarking this. I will come back when I have something worth adding.
Carryover and the ghost peak from last week's standard — what changed since Replied, post #81 · Analytics › HPLC & UHPLC · 28 Jun 2026 · 24 likes Typical suitability criteria are a replicate area relative standard deviation below about two per cent, a tailing factor inside a defined window, a resolution minimum…
Second pass at: Absence of evidence and evidence of absence Replied, post #30 · Research Methods › Statistics · 25 Jun 2026 · 5 likes I had written a reply contradicting post #26 and deleted it. Here is what survived. I changed my mind about Absence of evidence after someone here asked me for the…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #64 · Analytics › HPLC & UHPLC · 23 Jun 2026 · 4 likes I read the earlier replies on Carryover twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing with what was said rather…
When a dose reduction is the correct response to a side effect Replied, post #32 · Practice › Dosing & titration · 23 Jun 2026 · 19 likes Narrowing post #31, because the general version has more than one answer. How the published trials escalated: they used specific step sizes and intervals. The STEP…
Official shortage notices and what they authorise Replied, post #108 · Access › Shortages · 15 Jun 2026 · 17 likes The honest answer on official shortage notices is that it depends, and the useful part is the list of what it depends on. Four items, in rough order of how much they…
Pancreatitis history and the risk calculus Replied, post #19 · Safety › Contraindications · 15 Jun 2026 · 1 like On post #17 — agreed on the reasoning, with one qualification. Allergy to the specific compound: true allergy is rare but possible. Any prior allergic reaction to the…
Injection volume, overload, and peak distortion Replied, post #47 · Analytics › HPLC & UHPLC · 12 Jun 2026 · 0 likes The question underneath injection volume is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it. Write down what you would…
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #14 · Pharmacology › Receptor biology · 9 Jun 2026 · 12 likes Worth separating two things that post #10 runs together. Ghrelin receptor agonism drives growth hormone release in pulses and also increases appetite, which is the…
Does dual agonism explain the effect size, or is it dose? Replied, post #18 · Compounds › Tirzepatide · 5 Jun 2026 · 18 likes Post #16 put the caveat in the right place and I want to underline it. The most useful thing anyone has posted about dual agonism in this category was a table of what…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #69 · Evidence › Journal club · 28 May 2026 · 0 likes I read post #65 twice before replying, because I had assumed the opposite. A request rather than an answer: could whoever has the primary source for indirect comparison…
Risk-of-bias tools and the judgement they conceal — does this still hold? Replied, post #7 · Evidence › Meta-analyses · 18 May 2026 · 3 likes Adding the measurement that post #4 says would settle it. Where the Risk-of-bias tools reasoning breaks down for me is the step from the group result to the individual…
Pinch or no pinch, and how needle length changes the answer — what changed since Replied, post #25 · Practice › Administration · 9 May 2026 · 18 likes I would rather this thread reach "we do not know" about Pinch than reach a confident answer that nobody can support when asked.
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #28 · Compounds › Tirzepatide · 7 May 2026 · 19 likes Sensible. I would want the same detail before I acted on it either.
Documenting a payment dispute without naming and shaming Replied, post #8 · Sourcing › Payments · 6 May 2026 · 4 likes Post #5 is the version of this I will quote in future. One addition. Fraud and scams: if a supplier demands payment upfront with no recourse if delivery fails, you are…
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #8 · Compounds › Tirzepatide · 29 Apr 2026 · 24 likes Adding the measurement that post #6 says would settle it. The dual agonism is not a marketing framing — GIP receptor and GLP-1 receptor engagement are both…
Coming back to: Measurement error in a self-reported exposure Replied, post #22 · Evidence › Study critique · 27 Apr 2026 · 24 likes Adding the measurement that post #19 says would settle it. Generalisability and validity are separate axes. A trial can be internally impeccable and still tell you…
Managing an unplanned gap in supply Replied, post #111 · Access › Shortages · 25 Apr 2026 · 28 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
Follow-up: Levothyroxine timing: a real interaction with a simple fix Replied, post #7 · Practice › Interactions · 24 Mar 2026 · 30 likes Research-use-only compounds have no interaction data of any kind, because interaction studies are done on medicines being developed for use in people.
Preprint servers and what screening they do Replied, post #93 · Evidence › Preprints · 18 Mar 2026 · 3 likes Agreed on all of that, and I have nothing to add to it.
Which fields on a certificate actually matter, ranked Replied, post #17 · Analytics › COA interpretation · 16 Mar 2026 · 20 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
Oral versus injected administration claims for BPC-157 Replied, post #10 · Compounds › Repair & healing peptides · 12 Mar 2026 · 0 likes Taking post #7 at face value and following it one step further. The pentadecapeptide sequence is short and stable enough to survive conditions that would degrade a…
An ABAB design with a data table and honest limitations — a second dataset Replied, post #31 · Research Methods › N-of-1 designs · 3 Mar 2026 · 11 likes Answering the question post #29 raises rather than the one it answers. Expectation effects in an unblinded self-experiment are large and are not a character flaw.…
Seven-day rolling means and why weekly readings mislead — one year on Replied, post #45 · Outcomes › Progress reports · 13 Feb 2026 · 7 likes Practical experience of Seven-day rolling, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it…
Alcohol: what is documented and what is folklore — the long version Replied, post #12 · Practice › Interactions · 20 Jan 2026 · 29 likes Useful. I have added it to my own notes with the date on it.
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #65 · Access › Pricing · 18 Jan 2026 · 5 likes Where I part company with post #61, and it is a narrow parting. Agreed on Price changes, with one qualification that I think matters. The reasoning holds for the case…
Distinguishing expected GI effects from something that needs urgent attention Replied, post #101 · Practice › Side effects · 14 Jan 2026 · 4 likes Discontinuation for adverse effects in the published trials was not rare at the higher doses. That number belongs in any discussion of tolerability and is usually left…
Older adults, sarcopenia risk, and the trade-off nobody quantifies Replied, post #74 · Clinical › Special populations · 12 Jan 2026 · 0 likes Two people in this thread mean different things by older adults and are disagreeing about the definition while believing they are disagreeing about the facts. Worth…
Pharmacy supply in the UK and the questions you will be asked Replied, post #6 · Regional › UK & Ireland · 9 Jan 2026 · 2 likes Nothing to add, except that this is the answer I would give if asked.
Vomiting: when it is expected and when it is a reason to stop Replied, post #83 · Practice › Side effects · 29 Dec 2025 · 5 likes Acknowledging rather than arguing. The reasoning holds as far as I can follow it.
Preprint servers and what screening they do Replied, post #8 · Evidence › Preprints · 26 Dec 2025 · 1 like This follows post #7 rather than contradicting it. How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi.…
Angle of injection and whether 90 degrees is always right Replied, post #68 · Practice › Administration · 19 Dec 2025 · 0 likes Post #66 and I disagree about the size of the effect, not about the direction. Where I would push back on the angle of injection consensus is the confidence, not the…
Severe gastroparesis and why this class is a poor fit — one year on Replied, post #22 · Safety › Contraindications · 10 Dec 2025 · 3 likes Quietly grateful for the plain phrasing. Not every thread gets that.
Coming back to: Feature request: should a dose-equivalence tool exist at all? Replied, post #34 · Data & Tools › Calculators · 10 Dec 2025 · 0 likes Grateful for the specificity. Vague answers to this question are what sent me looking.
Tracking a preprint to publication: a worked example Replied, post #53 · Evidence › Preprints · 5 Dec 2025 · 0 likes The arithmetic on tracking a preprint is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will catch it.
Sequence verification for an obscure compound: how it is done — what changed since Replied, post #80 · Compounds › Other compounds · 25 Nov 2025 · 21 likes Thank you for taking the time. That was more work than a reply usually is.
Meeting a protein target on a suppressed appetite Replied, post #36 · Nutrition & Training › Protein & intake · 19 Nov 2025 · 29 likes Maintenance changes the calculation and almost nobody revisits their target when they get there. Adding this to the thread rather than to the wiki, because I am not…
Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Replied, post #90 · Compounds › Tirzepatide · 17 Nov 2025 · 0 likes Taking post #87 at face value and following it one step further. Adding what did not work for me on tirzepatide titration schedules, since the failures never get…
Oral semaglutide bioavailability and its variability between people Replied, post #14 · Compounds › Oral incretins · 10 Nov 2025 · 0 likes On variability: the between-person spread in exposure for oral semaglutide is wide enough that two people on the same dose can have quite different plasma…
Interpreting a result that disagrees with the supplier's certificate Replied, post #9 · Sourcing › Independent verification · 9 Nov 2025 · 5 likes Trying to state the interpreting a result position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes…
Second pass at: The mass-error checker and its intended scope Replied, post #55 · Data & Tools › Calculators · 4 Nov 2025 · 0 likes Post #54 put the caveat in the right place and I want to underline it. A saved calculation is worth more than a remembered one. Write down the inputs alongside the…
What pooling buys you and what it destroys Replied, post #53 · Evidence › Meta-analyses · 29 Oct 2025 · 10 likes Post #52 is right about the mechanism and I think understates the practical bit. Pooling buys looks different depending on whether you are reading the primary…
Revisiting: GLP-1 receptor distribution: central and peripheral Replied, post #50 · Pharmacology › Receptor biology · 9 Oct 2025 · 6 likes Nothing in receptor biology tells you what is in the vial, which is worth remembering when a mechanistic thread starts being used to justify a sourcing decision. That…
Thyroid function tests during substantial weight change Replied, post #82 · Clinical › Bloodwork · 3 Oct 2025 · 27 likes Where I part company with post #78, and it is a narrow parting. Practical experience of thyroid function tests during substantial, offered as one case with the…
NHS criteria and how they are applied in practice — the long version Replied, post #8 · Regional › UK & Ireland · 30 Sep 2025 · 1 like I had written a reply contradicting post #6 and deleted it. Here is what survived. I would rather this thread reach "we do not know" about NHS criteria than reach a…
Coming back to: Where the integrator drew the baseline, and how much it moved the number Replied, post #16 · Analytics › HPLC & UHPLC · 30 Sep 2025 · 3 likes Trying to state the integrator position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes that test.
Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a… Replied, post #28 · Analytics › Method validation · 26 Sep 2025 · 19 likes Range: the concentration range over which the method has been validated. Going outside the validated range is going outside the method's demonstrated performance.
Payment method and the leverage it gives you, ranked Replied, post #50 · Sourcing › Payments · 21 Sep 2025 · 0 likes Speaking only to payment method as I have actually seen it, rather than as it is usually described: the effect is real, it is smaller than the thread suggests, and the…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #128 · Wellbeing › Mental health · 8 Sep 2025 · 30 likes Post #125 answers the question as asked. The question underneath it is different. The strongest argument against my own position on history of disordered eating, stated…
Why catalogue breadth is not evidence of anything — what changed since Replied, post #22 · Compounds › Other compounds · 18 Aug 2025 · 3 likes Post #18 and I disagree about the size of the effect, not about the direction. Thymosin alpha-1 has a regulatory history in several jurisdictions and a real clinical…
[2026 update] Does dual agonism explain the effect size, or is it dose? Replied, post #2 · Compounds › Tirzepatide · 17 Aug 2025 · 7 likes Worth separating two things that the opening post runs together. SURMOUNT-4's randomised withdrawal design is the strongest available evidence about what happens on…
Temperature loggers worth the money Replied, post #19 · Devices › Cold chain · 16 Aug 2025 · 8 likes Helpful, and short, which on this subject is harder than long.
Revisiting: Why a compound being unapproved is not the same as being illegal to possess Replied, post #80 · Sourcing › Regulatory · 15 Aug 2025 · 24 likes Agreed on compound being unapproved, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it…
[2026 update] Citation sweep results: how many references did not say what was claimed Replied, post #46 · Meta › Wiki maintenance · 25 Jul 2025 · 0 likes That is clearer than the version I had in my head. Thank you.
Follow-up: Why the titration planner refuses to produce a schedule below a floor Replied, post #33 · Data & Tools › Calculators · 24 Jun 2025 · 30 likes Building on post #30 rather than restating it. I read the earlier replies on titration planner refuses twice before writing this, because I had assumed the opposite and…
Repeatability versus intermediate precision Replied, post #11 · Analytics › Method validation · 18 Jun 2025 · 1 like Two claims get bundled together under repeatability versus intermediate precision and they need separating. The descriptive one — this is what was observed — is usually…
Lean mass preservation: what the evidence supports Replied, post #27 · Outcomes › Body composition · 21 May 2025 · 0 likes The most useful protocol is the one you will actually repeat identically. An imperfect measurement repeated consistently beats a better one repeated carelessly.
A claim built entirely on a subgroup analysis Replied, post #45 · Evidence › Study critique · 20 May 2025 · 15 likes Building consensus on which criticisms matter: if everyone agrees that the sample size is small but only you think that affects the conclusion, maybe your criticism is…
Pregnancy as an absolute contraindication Replied, post #50 · Safety › Contraindications · 18 May 2025 · 24 likes The arithmetic in post #49 is right; the assumption feeding it is the part to check. Labelling differs between jurisdictions for the same molecule, so quoting a…
Research-use-only labelling: what it means and what it does not — the long version Replied, post #151 · Sourcing › Regulatory · 13 May 2025 · 20 likes Reframing Research-use-only labelling slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes.…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #85 · Sourcing › Independent verification · 12 May 2025 · 22 likes Worth stating the null on Janoshik before we explain it: the observation may be nothing. That possibility deserves a sentence and usually does not get one.
Follow-up: Documentation that appears only after payment Replied, post #66 · Sourcing › Red flags · 11 May 2025 · 12 likes What I can speak to on Documentation is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.
Shakes versus food: a pragmatic assessment — the long version Replied, post #16 · Nutrition & Training › Protein & intake · 5 May 2025 · 0 likes If someone has run Shakes versus food properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Replied, post #54 · Compounds › Secretagogues & GH axis · 2 May 2025 · 3 likes The arithmetic in post #53 is right; the assumption feeding it is the part to check. Tesamorelin is the compound in this family with the strongest regulatory evidence…
Dizziness on standing: the ordinary explanation first Replied, post #19 · Nutrition & Training › Hydration & electrolytes · 27 Apr 2025 · 0 likes An honest declaration on dizziness on standing: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.
Delayed gastric emptying and oral medication absorption: which drugs matter Replied, post #60 · Practice › Interactions · 25 Apr 2025 · 11 likes SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of…
Validating a calculator against hand arithmetic — what changed since Replied, post #30 · Data & Tools › Calculators · 23 Apr 2025 · 25 likes A calculator that shows its working is worth ten that give an answer. The whole value is being able to see which step you disagree with. A guess, clearly labelled as one.
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #6 · Sourcing › Independent verification · 23 Apr 2025 · 25 likes The record shows what was measured. Everything beyond that is inference and this site tries to keep the line visible. I would be interested in a counterexample if…
Second pass at: Cross-border purchase within the EU: the actual rules Replied, post #120 · Access › International · 24 Mar 2025 · 22 likes Import rules for personal use: what you can import for personal use depends on your country's rules, not on where it is sold. Checking your country's rules before…
When "no data" is the complete and final answer Replied, post #127 · Compounds › Other compounds · 24 Mar 2025 · 0 likes Dose conversions between related compounds in this subcategory are made far too casually. Structural similarity does not imply potency similarity and frequently does…
Retatrutide dose escalation in the published trials Replied, post #31 · Compounds › Retatrutide · 20 Mar 2025 · 0 likes Heart rate increased in a dose-dependent way in the phase 2 work. That is not a footnote — it is one of the specific things phase 3 exists to characterise, and it is…
Biased agonism: a real phenomenon, an over-used explanation Replied, post #80 · Pharmacology › Receptor biology · 11 Mar 2025 · 27 likes Narrowing post #79, because the general version has more than one answer. My understanding of biased agonism is a few years old and may have been superseded. If it has…
Distinguishing a deletion sequence by mass alone Replied, post #124 · Analytics › Mass spectrometry · 23 Feb 2025 · 9 likes Trying to state the distinguishing a deletion sequence position in a way that someone who disagrees would recognise as fair, because I do not think the version in this…
The topic list is dense — is that deliberate? Replied, post #77 · Meta › Site feedback · 4 Jan 2025 · 5 likes I would be cautious about generalising from the topic list example above. It is a good example. It is one example.
Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #38 · Compounds › Semaglutide · 25 Dec 2024 · 9 likes Building on post #35 rather than restating it. On dose steps: the four-week interval in the pivotal programme was a trial design choice, and slower escalation was not…
Second pass at: Multiplicity when you track fifteen variables Replied, post #2 · Research Methods › Statistics · 20 Dec 2024 · 0 likes I have three months of notes on Multiplicity and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite…
Identical chromatograms across two different lots Replied, post #62 · Sourcing › Red flags · 14 Dec 2024 · 15 likes Narrowing post #60, because the general version has more than one answer. Where the same certificate image appears with different lot numbers, that is a documentation…
Washout with a one-week half-life: the arithmetic Replied, post #82 · Research Methods › N-of-1 designs · 7 Dec 2024 · 31 likes If someone has run washout properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #46 · Evidence › Journal club · 29 Nov 2024 · 9 likes The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping.
When a red flag was a misunderstanding, and the retraction Replied, post #24 · Sourcing › Red flags · 28 Sep 2024 · 13 likes What I would want before treating red flag as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing.
Promotion criteria, and the one that stops most nominations Replied, post #58 · Documentation › Doc review · 10 Sep 2024 · 19 likes I had written a reply contradicting post #54 and deleted it. Here is what survived. If you are new and reading this thread for the answer to promotion criteria: the…
High-resolution MS on aggregates and what it can see — one year on Replied, post #53 · Analytics › Mass spectrometry · 20 Aug 2024 · 0 likes This follows post #50 rather than contradicting it. Resolution: "high resolution" commonly means Not the answer, but possibly the question that gets there.
Guidelines revision: what changed and why Replied, post #74 · Meta › Announcements · 27 Jul 2024 · 2 likes Archives: older announcements are archived by date. Checking archives is useful if you want to know what changed when. The answer changed when I changed how I was…
Cold packs, phase-change material, and what survives ten days Replied, post #134 · Sourcing › Logistics · 22 Jul 2024 · 18 likes Taking post #133 at face value and following it one step further. Reading this cold packs thread as someone who came in with a fixed view: the third and seventh replies…
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #93 · Practice › Dosing & titration · 9 Jul 2024 · 22 likes Same experience here, different supplier, so it is at least not unique to one of them.
The mass-error checker and its intended scope Replied, post #64 · Data & Tools › Calculators · 21 Jun 2024 · 8 likes Fine by me. I had wanted a stronger conclusion and there is not one available.