k.fonseca

TL2 · Valencia

Contributes reviews on supplier material. Based in Valencia.

Joined 16 November 2024 · last posted 4d

98 posts, newest first. Showing up to 150.

How to ask a question when you cannot say why you are asking it Replied, post #50 · Start Here › How to Ask · 24 Jul 2026 · 13 likes Coming back to post #48, because the follow-up matters more than the original answer. Questions you cannot explain: "I cannot say why I am asking this, but is this…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #113 · Sourcing › Independent verification · 22 Jul 2026 · 25 likes My experience of Interpreting a result contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #68 · Evidence › Journal club · 15 Jul 2026 · 13 likes I had read the opposite somewhere and cannot now find where, which tells me something.
Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #40 · Clinical › Comorbidities · 12 Jul 2026 · 0 likes What I would check first on Osteoarthritis and mechanical versus metabolic is whether the thing being measured moved or whether the way of measuring it moved. Those…
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #72 · Outcomes › Progress reports · 8 Jul 2026 · 12 likes Where I part company with post #68, and it is a narrow parting. The best progress reports here read as records rather than as arguments, and that difference is visible…
Second pass at: Cagrilintide molecular characteristics and analytical considerations Replied, post #5 · Compounds › Cagrilintide & amylin analogues · 7 Jul 2026 · 0 likes Research-use-only cagrilintide is not approved for human use and the published evidence base is a clinical-trial evidence base. Those two facts sit uncomfortably…
GIP receptor agonism and the argument about direction — does this still hold? Replied, post #7 · marked as the solution · Pharmacology › Receptor biology · 6 Jul 2026 · 23 likes Glucagon receptor agonism raises energy expenditure and promotes hepatic fat oxidation. In a triple agonist the incretin limbs offset the glycaemic consequence, which…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #108 · Evidence › Journal club · 6 Jul 2026 · 0 likes I read post #106 twice before replying, because I had assumed the opposite. Reframing indirect comparison slightly, because I think the disagreement is about the…
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #13 · Compounds › Retatrutide · 24 Jun 2026 · 33 likes On analysis: a chromatographic purity figure for an investigational compound is harder to interpret than for a well-characterised one, because there is no reference…
Research-use-only status: what it means legally and practically Replied, post #62 · Compounds › Other compounds · 21 Jun 2026 · 0 likes Picking up post #61: that is the part I would want checked first. I keep a log for research-use-only status specifically because my memory of it turned out to be…
An appeal that succeeded, with the letter structure — the long version Replied, post #129 · Access › Insurance & coverage · 20 Jun 2026 · 3 likes Post #128 is the version of this I will quote in future. One addition. Appeal deadlines are strict and are stated in the letter. Missing one is the most avoidable way…
Tracking a shortage from primary sources rather than rumour Replied, post #54 · Access › Shortages · 16 Jun 2026 · 33 likes Post #50 put the caveat in the right place and I want to underline it. Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long…
Racemisation and why it is invisible to a mass measurement Replied, post #114 · Analytics › Impurities & related substances · 14 Jun 2026 · 0 likes Practical answer on racemisation, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide whether the…
Comparing prices across jurisdictions without misleading yourself Replied, post #79 · Access › Pricing · 14 Jun 2026 · 10 likes Post #77 is the version of this I will quote in future. One addition. Comparing prices across jurisdictions was covered in the wiki last year and the page has a review…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #39 · Compounds › Oral incretins · 12 Jun 2026 · 11 likes Post #36 is right about the mechanism and I think understates the practical bit. Why administration conditions matter for oral semaglutide and not for injectables: the…
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #79 · Practice › Storage & stability · 7 Jun 2026 · 6 likes Two people in this thread mean different things by reconstituted and are disagreeing about the definition while believing they are disagreeing about the facts. Worth…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #11 · Analytics › HPLC & UHPLC · 6 Jun 2026 · 0 likes Taking post #10 at face value and following it one step further. Practical note on Carryover: write down what you expect before you look. The number of times I have…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #78 · Sourcing › Logistics · 23 May 2026 · 22 likes Source for the Regional warehouse stock versus direct figure, since it was asked for. It is in the discussion rather than the abstract, which is why the version…
Journal club: semaglutide in MASH, and surrogate endpoints Replied, post #19 · Evidence › Journal club · 17 May 2026 · 10 likes Post #17 and I disagree about the size of the effect, not about the direction. Where the group cannot agree, record the disagreement rather than resolving it by…
Run-in periods and the population they select Replied, post #115 · Evidence › Trials · 11 May 2026 · 20 likes The confident answers on run-in periods and the well-sourced answers are not the same answers, which is the most useful thing I have learned reading this category.
Coming back to: Why a preprint's supplementary material is often the best part Replied, post #47 · Evidence › Preprints · 7 May 2026 · 13 likes Building on post #44 rather than restating it. Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in…
Revisiting: Absolute versus relative contraindications Replied, post #80 · Safety › Contraindications · 2 May 2026 · 30 likes Everything in post #76 holds. The case it does not cover is the one I have. Since Absolute versus relative contraindications keeps coming up, it should probably be a…
Amylin receptor signalling and satiety — what changed since Replied, post #70 · Pharmacology › Receptor biology · 29 Apr 2026 · 0 likes Coming back to post #66, because the follow-up matters more than the original answer. The area postrema sits outside the blood-brain barrier and is where a great deal…
Converting between mg/mL and units per dose, both directions — the long version Replied, post #42 · Practice › Reconstitution · 20 Apr 2026 · 19 likes The arithmetic in post #39 is right; the assumption feeding it is the part to check. Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #115 · Analytics › Mass spectrometry · 19 Apr 2026 · 0 likes Quantitation by MS: most quantitation is done by LC-UV detection at 214 nm, not by MS, because extinction coefficients are better known. MS can quantify if an internal…
Reference intervals: how they are constructed and why one in twenty flags Replied, post #83 · Clinical › Bloodwork · 19 Apr 2026 · 17 likes Bringing the actual numbers with intervals to an appointment is far more useful than describing them, and clinicians here consistently say so.
Reference intervals: how they are constructed and why one in twenty flags Replied, post #68 · Clinical › Bloodwork · 21 Mar 2026 · 1 like Adding thanks rather than a view. I do not have a view worth the space.
Adsorptive losses at low concentration, and why dilute solutions are fragile Replied, post #20 · Practice › Storage & stability · 18 Mar 2026 · 0 likes Coming back to post #18, because the follow-up matters more than the original answer. My experience of adsorptive losses contradicts the reply above. I am posting it as…
Grapefruit: why this class is not the class that cares Replied, post #25 · Practice › Interactions · 9 Mar 2026 · 17 likes Since grapefruit keeps coming up, it should probably be a maintained page rather than a recurring thread. I am happy to draft it if someone with more direct experience…
The "under review" status pill and when a moderator applies it Replied, post #7 · Evidence › Preprints · 4 Mar 2026 · 8 likes Confirming post #4 from a second method, which matters more than confirming it from a second person. Peer review as a filter: published papers have survived a review…
The lowest dose that does anything: is that a real question? Replied, post #32 · Practice › Dosing & titration · 3 Mar 2026 · 12 likes If symptoms reset at each step, that is the expected pattern rather than a sign that the previous adaptation was imaginary. Every dose increase is a new exposure.
Is "synergy" the right word for the combination data? Replied, post #5 · Compounds › Cagrilintide & amylin analogues · 27 Feb 2026 · 27 likes The honest summary of the evidence base: a coherent mechanism, good phase 2 data in combination, and much less standalone human data than the volume of discussion…
Second pass at: Where impurities in solid-phase peptide synthesis come from Replied, post #14 · Analytics › Impurities & related substances · 21 Feb 2026 · 0 likes Incomplete deprotection leaves a protecting group attached, raising the mass substantially and usually pushing retention much later. A late-eluting peak on a peptide…
Chain of custody for a sample you posted yourself — one year on Replied, post #5 · Sourcing › Independent verification · 20 Feb 2026 · 4 likes On Chain of custody, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the…
[2026 update] A rising related-substance total over six months: degradation or method… Replied, post #73 · Analytics › Impurities & related substances · 20 Feb 2026 · 0 likes Off-target structures: if the sequence synthesis goes wrong, a completely different amino acid can be incorporated. The resulting off-target peptide is a structural…
Reading an interaction checker output critically Replied, post #124 · Practice › Interactions · 19 Feb 2026 · 7 likes Post #122 answers the question as asked. The question underneath it is different. An update on my earlier reading an interaction checker output post: the pattern held…
A site rotation scheme that is easy enough to actually follow Replied, post #3 · Practice › Administration · 9 Feb 2026 · 3 likes Two things can be true about site rotation scheme at once: the mechanism is plausible and the evidence for the size of the effect is thin. Most of the argument here is…
Stability of BPC-157 in solution: what has been measured — one year on Replied, post #7 · Compounds › Repair & healing peptides · 7 Feb 2026 · 7 likes Taking post #6 at face value and following it one step further. The claim about Stability of BPC-157 upthread is stronger than its source supports. I have read the…
Dizziness on standing and the electrolyte explanation Replied, post #5 · Practice › Side effects · 31 Jan 2026 · 0 likes The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of…
Search filters: what is missing Replied, post #21 · Meta › Site feedback · 26 Jan 2026 · 1 like Feature requests: if the site would work better with a feature it does not have (better search, different filtering, new section) suggest it here with the reasoning.…
When your prescriber and the evidence disagree Replied, post #3 · Clinical › Prescriber conversations · 22 Jan 2026 · 4 likes Worth stating the null on prescriber before we explain it: the observation may be nothing. That possibility deserves a sentence and usually does not get one.
Second pass at: Metformin co-administration and additive GI effects Replied, post #37 · Practice › Interactions · 22 Jan 2026 · 21 likes On post #33 — agreed on the reasoning, with one qualification. SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to…
Follow-up: A supplier that answers analytical questions with restated claims Replied, post #58 · Sourcing › Red flags · 21 Jan 2026 · 0 likes An unexplained discrepancy that the supplier declined to address is a legitimate thing to record, stated as exactly that and nothing more.
Distinguishing expected GI effects from something that needs urgent attention Replied, post #40 · Practice › Side effects · 6 Jan 2026 · 7 likes Where I part company with post #38, and it is a narrow parting. The published rates come from populations that were titrated on a defined schedule with clinical…
A parcel stationary at a customs facility for nine days Replied, post #17 · Sourcing › Logistics · 3 Jan 2026 · 10 likes Import restrictions by jurisdiction: what is legal to import for personal use varies enormously by country. Some jurisdictions are quite permissive; others are not.…
Why oral semaglutide needs an absorption enhancer at all Replied, post #62 · Compounds › Oral incretins · 27 Dec 2025 · 1 like On variability: the between-person spread in exposure for oral semaglutide is wide enough that two people on the same dose can have quite different plasma…
Reading U-100 graduations, with a conversion table Replied, post #3 · Devices › Syringes & needles · 15 Dec 2025 · 23 likes Answering the reading U-100 graduations question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on how…
Documentation that appears only after payment Replied, post #106 · Sourcing › Red flags · 14 Dec 2025 · 29 likes If you are new and reading this thread for the answer to documentation: the answer is conditional, the conditions are in the third reply, and the rest of the thread is…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Replied, post #70 · Compounds › Oral incretins · 1 Dec 2025 · 0 likes Trial adherence in an oral trial with strict administration requirements is genuinely worse than trial-published data often suggests. That is why the exposure…
What a good consultation looks like from the other side Started this topic · Clinical › Prescriber conversations · 23 Nov 2025 · 23 likes What a good consultation looks like from the other side — that is the question, and I have not found it answered plainly anywhere I have looked. Something about good…
Second pass at: Metformin co-administration and additive GI effects Replied, post #6 · Practice › Interactions · 14 Nov 2025 · 28 likes On post #4 — agreed on the reasoning, with one qualification. Where a published interaction study exists it usually reports an area-under-curve ratio, and that number…
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #59 · Compounds › Oral incretins · 9 Nov 2025 · 3 likes Building on post #56 rather than restating it. Genuine question rather than a rhetorical one: has anyone here actually observed SOUL trial and oral semaglutide, as…
Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Replied, post #18 · Compounds › Tirzepatide · 8 Nov 2025 · 0 likes Categorical response thresholds — the proportion reaching ten, fifteen or twenty per cent reduction — are more persuasive and less informative than the mean. They…
"Greater than or equal to 99%" as a specification rather than a result Replied, post #65 · Analytics › COA interpretation · 5 Nov 2025 · 2 likes An itemised related-substances table with retention times says considerably more about the synthesis than a single total. A total tells you how much is not the main…
Follow-up: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Replied, post #5 · Compounds › Retatrutide · 30 Oct 2025 · 29 likes The opening post and I disagree about the size of the effect, not about the direction. Phase 2 sample sizes are not adequate for safety characterisation of a novel…
A 40-week log with the measurement method stated Replied, post #79 · Outcomes › Progress reports · 27 Oct 2025 · 0 likes Longitudinal report with the method stated: same scale, same time of day, same conditions. A scale is a tool; use the same one each time. Consistency matters more than…
"Should I double up?" — answered once, at length, calmly Replied, post #26 · Practice › Administration · 23 Oct 2025 · 0 likes Letting a refrigerated preparation come to room temperature before injecting reduces the sting for most people. It is not a stability requirement, it is a comfort one,…
Realistic expectations for strength while losing weight quickly Replied, post #30 · Nutrition & Training › Resistance training · 22 Oct 2025 · 9 likes Having read the whole realistic expectations for strength thread before replying: the question in the first post has not actually been answered yet, and three of us…
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Replied, post #81 · Evidence › Journal club · 20 Oct 2025 · 11 likes The number people quote for STEP 4 is a central estimate presented without its interval, and the interval is wide enough that the estimate is nearly uninformative on…
Discussing something you have already been doing Replied, post #15 · Clinical › Prescriber conversations · 9 Oct 2025 · 24 likes A question phrased as "what would you want to see before considering X" is answerable and is not a request for X.
Documentation that appears only after payment Replied, post #42 · Sourcing › Red flags · 6 Oct 2025 · 0 likes Post #39 is right about the mechanism and I think understates the practical bit. Prices well below the rest of the market are a fact rather than a finding. They are…
Revisiting: Review: an evidence digest and the citation check that delayed it Replied, post #19 · Documentation › Doc review · 6 Oct 2025 · 15 likes Right, and stated more narrowly than I would have dared to state it.
Micronutrient adequacy at low total intake — does this still hold? Replied, post #10 · Nutrition & Training › Protein & intake · 5 Oct 2025 · 3 likes Timing of protein: spreading protein intake across the day, with some at each meal, is more practical than trying to hit the whole target at one sitting on suppressed…
How to read a forest plot, properly, from scratch Replied, post #31 · Evidence › Trials · 23 Sep 2025 · 3 likes Risk of bias: structured appraisal of internal validity. Key things to assess: randomisation method (was it truly random or could someone predict the next assignment),…
A parcel that arrived warm: a decision process, not a verdict Replied, post #40 · Practice › Storage & stability · 16 Sep 2025 · 13 likes Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear. I keep a log of…
Comparing two chromatograms from different laboratories, properly Replied, post #10 · Analytics › HPLC & UHPLC · 11 Sep 2025 · 3 likes Good question, well framed, and I would like to see it answered properly.
What a purity-only report leaves out Replied, post #10 · Sourcing › Independent verification · 9 Sep 2025 · 2 likes Answering the question post #6 raises rather than the one it answers. A record with four results over sixteen months is a thin record rather than a bad one, and the…
What a 2 ppm match establishes, and what it does not Replied, post #47 · Analytics › Mass spectrometry · 2 Sep 2025 · 15 likes That is a cleaner way of putting what I was circling around.
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #70 · Devices › Cold chain · 31 Aug 2025 · 0 likes Shipment during summer or to hot climates: consider shipping to a cold-storage facility rather than to home if temperatures will be high. Alternatively, time shipment…
Why the timeline is on the right and not the left Replied, post #60 · Meta › Site feedback · 27 Aug 2025 · 16 likes Taking post #57 at face value and following it one step further. Distinguishing three things in the timeline discussion that keep getting used interchangeably: the…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #111 · Evidence › Journal club · 25 Aug 2025 · 7 likes Reading order that works for these sessions: registry entry, methods, baseline table, primary result, then abstract last. Reading the abstract first anchors everything…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #99 · Evidence › Journal club · 24 Aug 2025 · 3 likes The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions. Worth saying I…
A ten-fold dose error caught before injection — one year on Replied, post #90 · Devices › Syringes & needles · 3 Aug 2025 · 0 likes If you are new and reading this thread for the answer to ten-fold dose error caught: the answer is conditional, the conditions are in the third reply, and the rest of…
Travel coolers and how long they really hold Replied, post #35 · Devices › Cold chain · 3 Aug 2025 · 0 likes This settles it for me, at least until somebody posts a reason it should not.
[2026 update] Reverting an edit that had no revision note Replied, post #8 · Meta › Wiki maintenance · 28 Jul 2025 · 31 likes That is clearer than the version I had in my head. Thank you.
Reverting an edit that had no revision note Replied, post #20 · Meta › Wiki maintenance · 25 Jul 2025 · 5 likes I changed my mind about reverting an edit after someone here asked me for the source and I could not produce one. That is worth saying out loud because it is the…
A field-by-field walk through a certificate of analysis Replied, post #121 · Analytics › COA interpretation · 17 Jul 2025 · 0 likes Everything in post #120 holds. The case it does not cover is the one I have. Peptide content and chromatographic purity are separate determinations and a certificate…
Journal club: the CagriSema phase 2 combination paper — a second dataset Replied, post #71 · Evidence › Journal club · 7 Jul 2025 · 11 likes Post #70 is the version of this I will quote in future. One addition. The practical version of CagriSema phase 2 combination paper is three sentences long. The rigorous…
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #49 · Clinical › Comorbidities · 10 Jun 2025 · 15 likes I would call the community position on Cardiovascular risk likely rather than established, and I would be comfortable defending that hedge.
Ipamorelin selectivity claims and where they came from Replied, post #41 · Compounds › Secretagogues & GH axis · 26 May 2025 · 0 likes Worth separating ipamorelin selectivity claims as a question about the compound from ipamorelin selectivity claims as a question about the documentation. They get…
Cost per milligram, computed honestly across formats — the long version Replied, post #77 · Access › Pricing · 25 Apr 2025 · 13 likes Taking post #76 at face value and following it one step further. A cheaper option that arrives slowly has a cost in the form of running out, and people rarely price…
Which panel is worth repeating and which is worth ignoring Replied, post #8 · Clinical › Bloodwork · 24 Apr 2025 · 1 like Glycaemic markers integrate over different periods. A point glucose and a longer-term marker disagreeing is not a contradiction; it is two different questions.
Delayed gastric emptying and oral medication absorption: which drugs matter Replied, post #27 · Practice › Interactions · 27 Mar 2025 · 5 likes Narrowing post #24, because the general version has more than one answer. Timing separation is the standard mitigation where absorption rate is the concern, and the…
Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #33 · Evidence › Journal club · 9 Mar 2025 · 27 likes Coming back to post #31, because the follow-up matters more than the original answer. The baseline characteristics table is the single most useful page for the…
The report format the maintainers ask for, and why each field is there — what changed… Replied, post #12 · Sourcing › Vendor reports · 27 Feb 2025 · 26 likes Agreed, and I will stop repeating the version of this I had been repeating.
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #103 · Compounds › Semaglutide · 9 Feb 2025 · 0 likes The useful distinction on Semaglutide half-life is between what was measured and what was inferred from it. Both end up in the same sentence and only one of them has…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #18 · Compounds › Tirzepatide · 9 Feb 2025 · 0 likes Posting my tirzepatide in type 2 diabetes numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who…
Oral semaglutide bioavailability and its variability between people — a second dataset Replied, post #134 · Compounds › Oral incretins · 29 Dec 2024 · 0 likes Orforglipron is a small molecule rather than a peptide, which changes almost everything about how it is made, stored and analysed. Comparing it to oral semaglutide as…
Coming back to: Preparing for an appointment: one page, three questions Replied, post #126 · Clinical › Prescriber conversations · 19 Dec 2024 · 0 likes A question phrased as "what would you want to see before considering X" is answerable and is not a request for X.
[2026 update] New subcategory: rationale and scope Replied, post #7 · Meta › Announcements · 16 Nov 2024 · 0 likes A note on scope: what I am saying about New subcategory applies to the case in the first post and I would not extend it further without checking.
Fixed versus detachable needles: the trade-offs Replied, post #6 · marked as the solution · Devices › Syringes & needles · 15 Nov 2024 · 7 likes Post #2 put the caveat in the right place and I want to underline it. The quoted dead-volume figures for common configurations vary between manufacturers and the…
Second pass at: Reimbursement variation across member states Replied, post #25 · Regional › European Union · 28 Oct 2024 · 21 likes The arithmetic in post #24 is right; the assumption feeding it is the part to check. The bit of Reimbursement variation across member states that nobody enjoys is that…
Second pass at: Multiplicity when you track fifteen variables Started this topic · Research Methods › Statistics · 20 Oct 2024 · 60 likes Posting this under the heading it deserves: Second pass at: Multiplicity when you track fifteen variables Everything below is what sits behind that. Two things I would…
Blind submission and why it changes minds Replied, post #48 · Sourcing › Independent verification · 29 Aug 2024 · 0 likes Post #46 is right about the mechanism and I think understates the practical bit. I have three months of notes on blind submission and the honest summary is that the…
High-resolution MS on aggregates and what it can see — one year on Replied, post #23 · Analytics › Mass spectrometry · 14 Aug 2024 · 0 likes Trifluoroacetate adducts are common in material purified with TFA and are one reason a mass spectrum from a peptide can look busier than expected.
The mass-error checker and its intended scope Replied, post #165 · Data & Tools › Calculators · 29 Jul 2024 · 5 likes If someone has run mass-error checker properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.
Oral contraceptives and delayed emptying: what the data shows Replied, post #49 · Practice › Interactions · 15 Jul 2024 · 7 likes Thyroid medications: semaglutide is associated with a slowing of gastric emptying, which might affect thyroid medication absorption if they are taken very close…
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #139 · Practice › Dosing & titration · 10 Jul 2024 · 4 likes Picking up post #138: that is the part I would want checked first. Reframing Splitting a weekly dose slightly, because I think the disagreement is about the question…